Andrew McMichael
Andrew McMichael Academic advisor | Hugh McDevitt | |
---|---|---|
Doctoral students | Malegapuru William Makgoba, Suranjith Seneviratne |
Sir Andrew James McMichael,
Early life and education
McMichael was born in London on 8 November 1943 to
Career and research
After his PhD McMichael completed his postdoctoral research supervised by Hugh McDevitt at Stanford University.[4] In 1977 he returned to the UK to study the T cell response to HIV infection. His research group have created two HIV vaccines which were tested in phase I clinical trials.[5] McMichael became director of the Weatherall Institute of Molecular Medicine in 2000, and remained so until 2012.[6] He founded the MRC Human Immunology Unit in 1998 as honorary director until 2010.
McMichael has supervised over 55 DPhil students over his career,[5] many of whom have gone on to become leading immunologists themselves:
- Douglas F. Nixon, Professor of Immunology in Medicine, Weill Cornell Medical College.[7][8]
- Malegapuru Makgoba, Professor of Immunology and former Vice-Chancellor & Principal of the University of KwaZulu-Natal.[9]
- Matilu Mwau Professor and Executive Director of the Consortium for National Health Research[10][11]
- Paul Bowness, Professor of Experimental Rheymatology[12][13]
- Awen Gallimore, Professor of Cancer Immunology[14][15][16]
- Paul Klenerman, Sidney Truelove Professor of Gastroenterology[17][18][19]
- Dan Barouch, Professor of Medicine and Director of the Center for Virology and Vaccine Research at Harvard Medical School[20][21]
- Sophie Hambleton, Professor of Paediatrics & Immunology[22][23][24]
- Suranjith Seneviratne, Professor, Director of the Centre for Mast Cell Disorders and the President of the UK-Sri Lanka Immunology Foundation.[25][26][27]
- Ling-Pei Ho, Professor of Respiratory Immunology[28][29]
In addition McMichael supervised postdoctoral researchers, including Tomáš Hanke (Professor of Vaccine Immunology), and Sarah Rowland-Jones (Professor of Immunology).[30][31][32][33]
Awards and honours
- Fellow of the Royal Society (1992)[34]
- Member of the European Molecular Biology Organisation (2004)
- Novartis Prize for Basic Immunology (1998)[35]
- Rose Payne Distinguished Scientist award (1998)[35][36]
- Fellow of the Academy of Medical Sciences (1998)[37]
- Sheikh Hamdan Award (2000)[35][38]
- Ambuj Nath Bose Prize, Royal College of Physicians (2001)[35]
- Ernst Chain Prize (2006)[35][39]
- Nature/NESTA Award for Lifetime Mentoring (2006)[40][41]
- Knighthood for services to medical science (2008)[42][43]
Personal life
In 1968 McMichael married Kathryn 'Kate' Elizabeth Cross, they have two sons and one daughter.[2] McMichael enjoys walking and skiing at his house in La Salle les Alpes, France.[2]
Notable works
McMichael, A. J.; Ting, A.; Zweerink, H. J.; Askonas, Brigitte A. (1977). "HLA restriction of cell-mediated lysis of influenza virus-infected human cells". Nature. 270 (5637): 524–526.
McMichael, A. J.; Gotch, F. M.; Noble, G. R.; Beare, P. A. (7 July 1983). "Cytotoxic T-cell immunity to influenza". The New England Journal of Medicine. 309 (1): 13–17.
Townsend, A. R.; Rothbard, J.; Gotch, F. M.; Bahadur, G.; Wraith, D.; McMichael, A. J. (28 March 1986). "The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides". Cell. 44 (6): 959–968.
Phillips, R. E.; Rowland-Jones, S.; Nixon, D. F.; Gotch, F. M.; Edwards, J. P.; Ogunlesi, A. O.; Elvin, J. G.; Rothbard, J. A.; Bangham, C. R. (12 December 1991). "Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition". Nature. 354 (6353): 453–459.
Altman, J. D.; Moss, P. A.; Goulder, P. J.; Barouch, D. H.; McHeyzer-Williams, M. G.; Bell, J. I.; McMichael, A. J.; Davis, M. M. (4 October 1996). "Phenotypic analysis of antigen-specific T lymphocytes". Science. 274 (5284): 94–96.
Goonetilleke, Nilu; Liu, Michael K. P.; Salazar-Gonzalez, Jesus F.; Ferrari, Guido; Giorgi, Elena; Ganusov, Vitaly V.; Keele, Brandon F.; Learn, Gerald H.; Turnbull, Emma L. (8 June 2009). "The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection". The Journal of Experimental Medicine. 206 (6): 1253–1272.
Liu, Michael K. P.; Hawkins, Natalie; Ritchie, Adam J.; Ganusov, Vitaly V.; Whale, Victoria; Brackenridge, Simon; Li, Hui; Pavlicek, Jeffrey W.; Cai, Fangping (January 2013). "Vertical T cell immunodominance and epitope entropy determine HIV-1 escape". The Journal of Clinical Investigation. 123 (1): 380–393.
Fellay, Jacques; Shianna, Kevin V.; Ge, Dongliang; Colombo, Sara; Ledergerber, Bruno; Weale, Mike; Zhang, Kunlin; Gumbs, Curtis; Castagna, Antonella (17 August 2007). "A Whole-Genome Association Study of Major Determinants for Host Control of HIV-1". Science. 317 (5840): 944–947.
Hill, Adrian V. S.; Allsopp, Catherine E. M.; Kwiatkowski, Dominic; Anstey, Nicholas M.; Twumasi, Patrick; Rowe, Pamela A.; Bennett, Stephen; Brewster, David; McMichael, Andrew J. (1991). "Common West African HLA antigens are associated with protection from severe malaria". Nature. 352 (6336): 595–600.
Braud, Veronique M.; Allan, David S. J.; O'Callaghan, Christopher A.; Söderström, Kalle; D'Andrea, Annalisa; Ogg, Graham S.; Lazetic, Sasha; Young, Neil T.; Bell, John I. (1998). "HLA-E binds to natural killer cell receptors CD94/NKG2A, B and C". Nature. 391 (6669): 795–799.
McMichael, Andrew J.; Rowland-Jones, Sarah L. (19 April 2001). "Cellular immune responses to HIV". Nature. 410 (6831): 980–987.
Appay, Victor; Dunbar, P. Rod; Callan, Margaret; Klenerman, Paul; Gillespie, Geraldine M.A.; Papagno, Laura; Ogg, Graham S.; King, Abigail; Lechner, Franziska (2002). "Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections". Nature Medicine. 8 (4): 379–385.
McMichael, Andrew J.; Borrow, Persephone; Tomaras, Georgia D.; Goonetilleke, Nilu; Haynes, Barton F. (2010). "The immune response during acute HIV-1 infection: clues for vaccine development". Nature Reviews Immunology. 10 (1): 11–23.
References
- ISBN 978-0-19-954088-4.
- ^ a b c Vetta, Sylvia (June 2014). "Sylvia Vetta meets Professor Sir Andrew McMichael, Oxford University Professor of Molecular Medicine" (PDF). Retrieved 11 February 2018.
- ProQuest 301272025.
- ^ "Interview with leading HIV vaccine researcher - Prof. Sir Andrew McMichael - 80,000 Hours". 80,000 Hours. 28 January 2014. Retrieved 11 February 2018.
- ^ a b "Andrew McMichael: Some final words - Nuffield Department of Medicine". www.ndm.ox.ac.uk. Retrieved 11 February 2018.
- ^ "Jenner Institute News" (PDF). May 2013. Retrieved 11 February 2018.
- ^ Nixon, Douglas F. (1990). Cytotoxic T cell immunity in HIV infection (Thesis). Thesis DPhil--University of Oxford.
- ^ "Nixon, Douglas".
- ^ Makgoba, M. W. (1983). Studies on the polymorphism of HLA class II antigens (Thesis). Thesis DPhil--University of Oxford.
- ^ Mwau, Matilu (2004). Clinical evaluation of a candidate HIV-1 Clade A DNA/MVA vaccine designed for Kenya (Thesis). Thesis DPhil--University of Oxford.
- ^ "Prof. Matilu Mwau – Consortium for National Health Research". www.keshop.co.ke. Archived from the original on 12 February 2018. Retrieved 11 February 2018.
- ^ Bowness, Paul (1993). Recognition of antigen and superantigen by cytotoxic lymphocytes (Thesis). Thesis DPhil--University of Oxford.
- ^ "Paul Bowness — University of Oxford, Medical Sciences Division". www.medsci.ox.ac.uk. Retrieved 11 February 2018.
- ^ Gallimore, Awen M. (1994). Simian immunodeficiency virus: specific cytotoxic T cell responses in cynomolgus macaques (Thesis). Thesis DPhil--University of Oxford.
- ^ "The Team". cancerimmunology.co.uk. Retrieved 11 February 2018.
- ^ "Professor Awen Gallimore - People - Cardiff University". Cardiff University. Retrieved 11 February 2018.
- ^ Klenerman, Paul (1995). Cytotoxic T cell antagonism in HIV infection (Thesis). Thesis DPhil--University of Oxford.
- ^ "Professor Paul Klenerman - Nuffield Department of Medicine". www.ndm.ox.ac.uk. Retrieved 12 February 2018.
- ^ "paul Klenerman". Loop. Retrieved 12 February 2018.
- ^ Barouch, Dan H. (1995). Peptide binding and presentation by HLA-A2 (Thesis). Thesis DPhil--University of Oxford.
- ^ "Immunology Faculty Member - Dan Barouch, MD, PhD". Harvard Medical School. 14 July 2014.
- ^ Hambleton, Sophie (2001). Notch and immunodominance in CD8+ T cell responses (Thesis). Thesis DPhil--University of Oxford.
- ^ "Staff Profile - Institute of Cellular Medicine - Newcastle University". www.ncl.ac.uk. Retrieved 12 February 2018.
- ^ "Newcastle Hospitals - Hambleton, Dr Sophie". www.newcastle-hospitals.org.uk. Retrieved 12 February 2018.
- ^ Seneviratne, Suranjith Luke (2003). Investigation of T cells in atopic disease (Thesis). Thesis DPhil--University of Oxford.
- ^ "Professor Suranjith Seneviratne, Allergy Medicine | Nuffield Health". www.nuffieldhealth.com. Retrieved 12 February 2018.
- ^ "Suranjith Seneviratne, MBBS, MD, FRCP, FRCPath, DPhil, FCCP | The Ehlers Danlos Society". The Ehlers Danlos Society. Retrieved 12 February 2018.
- ^ Ho, Ling-Pei (2004). The role of CD1d restricted NKT cells in the immunopathology of sarcoidosis (Thesis). Thesis DPhil--University of Oxford.
- ^ "Professor Ling-Pei Ho - Nuffield Department of Medicine". www.ndm.ox.ac.uk. Retrieved 12 February 2018.
- ^ "Professor Tomas Hanke - Nuffield Department of Medicine". www.ndm.ox.ac.uk. Retrieved 12 February 2018.
- ^ "Outsmarting HIV" (PDF). INTERNATIONAL INNOVATION.
- ^ "Professor Sarah L Rowland-Jones - Nuffield Department of Medicine". www.ndm.ox.ac.uk. Retrieved 12 February 2018.
- ^ "WiLS Database - Expert Women in Life Sciences". wils-database.embo.org. Retrieved 12 February 2018.
- ^ "Andrew McMichael". royalsociety.org. Retrieved 11 February 2018.
- ^ a b c d e Jones, J-P (5 May 2010). "You will shape the future, Imperial College London's Rector tells new graduates". Imperial College London. Retrieved 11 February 2018.
- ^ "Awards - American Society for Histocompatibility and Immunogenetics". www.ashi-hla.org. Retrieved 11 February 2018.
- ^ "Sir Andrew McMichael | The Academy of Medical Sciences". acmedsci.ac.uk. Retrieved 11 February 2018.
- ^ "Professor Andrew McMichael - Sheikh Hamdan Bin Rashid Al Maktoum Award for Medical Sciences - HMA". hmaward.org.ae. Retrieved 11 February 2018.
- ^ "Imperial College London - Ernst Chain prize for HIV vaccines researcher". www.imperial.ac.uk. Retrieved 11 February 2018.
- S2CID 5316736.
- S2CID 4380243.
- ^ "Dame honour for Oxfam executive". 14 June 2008. Retrieved 11 February 2018.
- PMID 23692824.