Angiotensin II receptor type 1
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RefSeq (protein) |
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Location (UCSC) | Chr 3: 148.7 – 148.74 Mb | Chr 13: 30.52 – 30.57 Mb | |||||||
PubMed search | [3] | [4] |
View/Edit Human | View/Edit Mouse |
Angiotensin II receptor type 1 (AT1) is a
Signaling cascade
The angiotensin receptor is activated by the
Function
The AT1 receptor mediates the major cardiovascular effects of angiotensin II. Effects include
Clinical significance
Due to the hemodynamic pressure and volume effects mediated by AT1 receptors, AT1 receptor antagonists are widely prescribed drugs in the management of hypertension and stable heart failure.[9]
Animal studies
Elements of the renin-angiotensin system have been widely studied in a large variety of vertebrate animals including amphibians, reptiles, birds, and mammals.[10]
AT1 receptor blockers have been shown to reduce fear memory recall in mice, but the reliability and relevance of this finding are to be determined.[11][12]
Gene
It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. At least four
A huge number of polymorphisms is reported in the databases for AT1R which provide an avenue to explore these polymorphisms for their implications in protein structure, function and drug efficacy. Methods In the current study all the SNPs (10234) reported in NCBI were analyzed and SNPs which were important in protein structure and drug interactions were identified. Structures of these polymorphic forms were modeled and in silico drug interaction studies were carried out. Results Result of the interaction studies with polymorphism was in correlation with the reported case. Two SNP mutated structures of AT1R i.e. rs780860717 (G288T), rs868647200 (A182C) shows considerably less binding affinities in case of all angiotensin receptor blockers (ARBs).[14]
Interactions
Angiotensin II receptor type 1 has been shown to
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000144891 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049115 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 27624282.
- PMID 6083400.
- S2CID 38235497.
- PMID 877549.
- ^ "Angiotensin II receptor blocker", Wikipedia, 2022-07-26, retrieved 2022-08-10
- PMID 6368215.
- PMID 24094510.
- PMID 26257395.
- ^ "Entrez Gene: AGTR1 angiotensin II receptor, type 1".
- S2CID 225071659.
- PMID 14657020.
- ^ Elton TS, Kuhn DE, Malana GE, Martin MM, Nuovo GJ, Pleister AP, Feldman DS (2007). "MiR-132 Regulates Angiotensin II Type 1 Receptor Expression Through a Protein Coding Region Binding Site". Circulation. 118 (18): S513.
- This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Further reading
- Matsusaka T, Ichikawa I (1997). "Biological functions of angiotensin and its receptors". Annual Review of Physiology. 59: 395–412. PMID 9074770.
- Allen AM, Moeller I, Jenkins TA, Zhuo J, Aldred GP, Chai SY, Mendelsohn FA (September 1998). "Angiotensin receptors in the nervous system". Brain Research Bulletin. 47 (1): 17–28. S2CID 24936475.
- Berry C, Touyz R, Dominiczak AF, Webb RC, Johns DG (December 2001). "Angiotensin receptors: signaling, vascular pathophysiology, and interactions with ceramide". American Journal of Physiology. Heart and Circulatory Physiology. 281 (6): H2337–H2365. S2CID 41296327.
- Arima S, Ito S (November 2001). "New insights into actions of the renin-angiotensin system in the kidney: concentrating on the Ang II receptors and the newly described Ang-(1-7) and its receptor". Seminars in Nephrology. 21 (6): 535–543. PMID 11709801.
- Stowasser M, Gunasekera TG, Gordon RD (December 2001). "Familial varieties of primary aldosteronism". Clinical and Experimental Pharmacology & Physiology. 28 (12): 1087–1090. S2CID 23091842.
- Padmanabhan N, Padmanabhan S, Connell JM (December 2000). "Genetic basis of cardiovascular disease--the renin-angiotensin-aldosterone system as a paradigm". Journal of the Renin-Angiotensin-Aldosterone System. 1 (4): 316–324. PMID 11967817.
- Thibonnier M, Coles P, Thibonnier A, Shoham M (2002). "Chapter 14 Molecular pharmacology and modeling of vasopressin receptors". Vasopressin and Oxytocin: From Genes to Clinical Applications. Progress in Brain Research. Vol. 139. pp. 179–96. PMID 12436935.
- Elton TS, Martin MM (March 2003). "Alternative splicing: a novel mechanism to fine-tune the expression and function of the human AT1 receptor". Trends in Endocrinology and Metabolism. 14 (2): 66–71. S2CID 45146964.
- Saavedra JM, Benicky J, Zhou J (2007). "Mechanisms of the Anti-Ischemic Effect of Angiotensin II AT( 1 ) Receptor Antagonists in the Brain". Cellular and Molecular Neurobiology. 26 (7–8): 1099–1111. S2CID 20245643.
- Oliveira L, Costa-Neto CM, Nakaie CR, Schreier S, Shimuta SI, Paiva AC (April 2007). "The angiotensin II AT1 receptor structure-activity correlations in the light of rhodopsin structure". Physiological Reviews. 87 (2): 565–592. PMID 17429042.
- Ariza AC, Bobadilla NA, Halhali A (2007). "[Endothelin 1 and angiotensin II in preeeclampsia]". Revista de Investigacion Clinica. 59 (1): 48–56. PMID 17569300.
- Xia Y, Zhou CC, Ramin SM, Kellems RE (September 2007). "Angiotensin receptors, autoimmunity, and preeclampsia". Journal of Immunology. 179 (6): 3391–3395. PMID 17785770.
- Mauzy CA, Hwang O, Egloff AM, Wu LH, Chung FZ (July 1992). "Cloning, expression, and characterization of a gene encoding the human angiotensin II type 1A receptor". Biochemical and Biophysical Research Communications. 186 (1): 277–284. PMID 1378723.
- Curnow KM, Pascoe L, White PC (July 1992). "Genetic analysis of the human type-1 angiotensin II receptor". Molecular Endocrinology. 6 (7): 1113–1118. PMID 1508224.
- Furuta H, Guo DF, Inagami T (February 1992). "Molecular cloning and sequencing of the gene encoding human angiotensin II type 1 receptor". Biochemical and Biophysical Research Communications. 183 (1): 8–13. PMID 1543512.
- Takayanagi R, Ohnaka K, Sakai Y, Nakao R, Yanase T, Haji M, et al. (March 1992). "Molecular cloning, sequence analysis and expression of a cDNA encoding human type-1 angiotensin II receptor". Biochemical and Biophysical Research Communications. 183 (2): 910–916. PMID 1550596.
- Bergsma DJ, Ellis C, Kumar C, Nuthulaganti P, Kersten H, Elshourbagy N, et al. (March 1992). "Cloning and characterization of a human angiotensin II type 1 receptor". Biochemical and Biophysical Research Communications. 183 (3): 989–995. S2CID 19816702.
- Gemmill RM, Drabkin HA (1992). "Report of the Second International Workshop on Human Chromosome 3 mapping". Cytogenetics and Cell Genetics. 57 (4): 162–166. PMID 1683828.
- Curnow KM, Pascoe L, Davies E, White PC, Corvol P, Clauser E (September 1995). "Alternatively spliced human type 1 angiotensin II receptor mRNAs are translated at different efficiencies and encode two receptor isoforms". Molecular Endocrinology. 9 (9): 1250–1262. S2CID 46112700.
- Marrero MB, Schieffer B, Paxton WG, Heerdt L, Berk BC, Delafontaine P, Bernstein KE (May 1995). "Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor". Nature. 375 (6528): 247–250. S2CID 4272223.
External links
- "Angiotensin Receptors: AT1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2014-02-28. Retrieved 2008-11-25.
- Human AGTR1 genome location and AGTR1 gene details page in the UCSC Genome Browser.