Animal testing on invertebrates

Most animal testing involves invertebrates, especially Drosophila melanogaster, a fruit fly, and Caenorhabditis elegans, a nematode. These animals offer scientists many advantages over vertebrates, including their short life cycle, simple anatomy and the ease with which large numbers of individuals may be studied. Invertebrates are often cost-effective,^[1] as thousands of flies or nematodes can be housed in a single room.

With the exception of some cephalopods in the European Union, invertebrate species are not protected under most animal research legislation, and therefore the total number of invertebrates used remains unknown.^[2]

Main uses

Animal testing
Main articles
Animal testing Alternatives to animal testing Animal testing regulations History of animal testing History of model organisms IACUC Laboratory animal sources Pain and suffering in laboratory animals Testing cosmetics on animals Toxicology testing Vivisection
Testing on
Invertebrates Frogs Primates Rabbits Rodents
Issues
Medical research Animal rights Animal welfare Animals (Scientific Procedures) Great ape research ban International primate trade
Cases
Brown Dog affair Cambridge University primates Pit of despair Silver Spring monkeys UCR 1985 laboratory raid Unnecessary Fuss
Companies
Jackson Laboratory Charles River Laboratories Covance, Harlan Huntingdon Life Sciences UK lab animal suppliers Nafovanny, Shamrock Farm
Groups/campaigns
AALAS AAAS ALF Americans for Medical Progress Boyd Group Cruelty Free International Dr. Hadwen Trust Foundation for Biomedical Research FRAME National Anti-Vivisection Society New England Anti-Vivisection Society PETA Physicians Committee for Responsible Medicine Primate Freedom Project Pro-Test SPEAK campaign SHAC Speaking of Research Understanding Animal Research
Writers/activists
Tipu Aziz Michael Balls Neal D. Barnard Colin Blakemore Simon Festing Gill Langley Ingrid Newkirk Bernard Rollin Jerry Vlasak Syed Ziaur Rahman
Categories
Animal testing Animal rights Animal welfare
v t e

Research on invertebrates is the foundation for current understanding of the genetics of animal development. C. elegans is especially valuable as the precise lineage of all the organism's 959 somatic cells is known, giving a complete picture of how this organism goes from a single cell in a fertilized egg, to an adult animal.^[3] The genome of this nematode has also been fully sequenced and any one of these genes can easily be inactivated through RNA interference, by feeding the worms antisense RNA.^[4] A major success in the work on C. elegans was the discovery that particular cells are programmed to die during development, leading to the discovery that programmed cell death is an active process under genetic control.^[5] The simple nervous system of this nematode allows the effects of genetics on the development of nerves to be studied in detail.^[6] However, the lack of an adaptive immune system and the simplicity of its organs prevent C. elegans from being used in medical research such as vaccine development.^[3]

The fly D. melanogaster is the most widely used animal in

• Animal testing on non-human primates
• Animal testing on rodents
• Testing cosmetics on animals
• Pain in invertebrates

References