Anti-Scl-70 antibodies

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Anti-Scl-70 (also called anti-topoisomerase I after the

anti-nuclear autoantibodies, seen mainly in diffuse systemic scleroderma (with a sensitivity of 28–70%), but is also seen in 10–18% of cases of the more limited form of systemic scleroderma called CREST syndrome.[2] Anti Scl-70 antibodies are associated with more severe scleroderma disease.[3]

The etymology of scl-70 consists of an abbreviation of scleroderma and a 70

kD extractable immunoreactive fragment that can be obtained from the otherwise larger (100–105 kD) target topoisomerase antigen (called the SCL-70 Antigen) of the antibodies.[4]

References

  1. PMID 2428564
    .
  2. ISBN 1-4160-2973-7
    . 8th edition.
  3. PMID 2547546
    .
  4. ^ Product Name: SCL-70 Antigen Archived 2006-03-19 at the Wayback Machine at ImmunoVision.com, retrieved April 2011
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