Anti-topoisomerase antibodies
Autoantibody | |
---|---|
Anti-Topoisomerase | |
Autoantigen Isoform |
Topoisomerase I (human) |
Autoantigen gene | TOP1 |
Affected organ(s) | Dermis |
Associated Disease(s) |
Scleroderma,
Systemic sclerosis |
Autoantibody Ig Class |
IgA
|
DR2 | |
HLA associations | DR15 |
DR16 | |
Other Susceptibility genes |
lymphoid protein tyrosine phos- |
Anti-topoisomerase antibodies (ATA) are
Epitopes and subtypes
Anti-topoisomerase antibodies can be classified according to their immunoglobulin class (IgM, IgG or IgA). IgG-ATA is found most frequently in scleroderma, with IgA being quite common but IgM very infrequent.[5]
Pathology
In
Increases in ATA+ in scleroderma and SLE are associated with increases in serum CTLA4.[10][11]
Genetics
HLA-DR2 (DR15 and DR16) are associated with scleroderma and systemic sclerosis. It has been found that patients with ATA that recognize the ET4 domain of topoisomerase were frequently HLA-DR2,[12] and in another population study it was found that DR-15 is associated with ATA in systemic sclerosis.[13] In addition to HLA-DR, the protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (1p13.2 - PTPN22), "CT/TT" genotype showed significant association with anti-topo I.[14] The TAP1 gene (6p21.3, HLA complex) has also been found in association with ATA+ sclerosis.[15]
References
- S2CID 24851422.
- ISBN 978-1-4160-2973-1. 8th edition.
- ^ JB Imboden, DB Hellmann, JH Stone. Current Rheumatology Diagnosis & Treatment, Second Edition. McGraw-Hill, 2007.
- S2CID 23132993.
- PMID 2161233.
- PMID 2431927.
- S2CID 33578122.
- PMID 17665460.
- S2CID 289409.
- PMID 15266059.
- PMID 12508774.
- PMID 7692859.
- S2CID 23157796.
- PMID 17133608.
- PMID 16112028.