Antibody mimetic

Source: Wikipedia, the free encyclopedia.

Antibody mimetics are organic compounds that, like

kDa
. (Antibodies are ~150 kDa.)

Nucleic acids and small molecules are sometimes considered antibody mimetics as well, but not artificial antibodies, antibody fragments and fusion proteins composed from these.

Common advantages over antibodies are better

therapeutic and diagnostic agents.[1]

Examples

Antibody mimetic Scaffold Molar mass Example drug
Affibody molecules[2] Z domain of Protein A 6 kDa ABY-025
Affilins[3]
Gamma-B crystallin
 20 kDa
Ubiquitin 10 kDa SPVF 2801
Affimers[4]
(Adhirons) 		Cystatin 12–14 kDa
Affitins[5] Sac7d (from Sulfolobus acidocaldarius) 7 kDa
Alphabodies[6] Triple helix coiled coil 10 kDa CMPX-1023
Anticalins[7] Lipocalins 20 kDa
Avimers[8] A domains of various membrane receptors 9–18 kDa
DARPins[9] Ankyrin repeat motif 10–19 kDa MP0112
Fynomers[10] SH3 domain of Fyn 7 kDa
Gastrobodies[11] Kunitz-type soybean trypsin inhibitor 20 kDa
Kunitz domain peptides[12]
 Kunitz domains of various protease inhibitors 6 kDa Ecallantide (Kalbitor)
Monobodies[13] 10th type III domain of fibronectin 10 kDa Pegdinetanib (Angiocept)
nanoCLAMPs[14] Carbohydrate Binding Module 32-2 (from Clostridium perfringens NagH) 16 kDa
Optimers[15] Flexible nucleic acid based scaffold; G-quadruplex 8-15 kDa
Repebodies[16] leucine-rich repeats
Pronectin™[17] fourteenth fibronectin type-III scaffold  of Human Fibronectin (14Fn3) 10 kDa
Centyrins[18] highly stable fibronectin type III (FN3) domain 10 kDa
Obodies[19] a high affinity binding protein domain engineered to bind to Hen Egg-white Lysozyme

See also

References

  1. PMID 19501012
    .
  2. PMID 18435759
    .
  3. PMID 17628592
    .
  4. PMID 22789061
    .
  5. PMID 18822295
    .
  6. PMID 25354530
    .
  7. S2CID 19992238
    .
  8. S2CID 84757398
    .
  9. PMID 18621567
    .
  10. PMID 17130124
    .
  11. PMID 34381153
    .
  12. PMID 16566296
    .
  13. PMID 17041261
    .
  14. PMID 28428153
    .
  15. ^ "Rapid identification and development of SARS-CoV-2 selective Optimers". Aptamer Group. 11 December 2020. Retrieved 2021-08-03.
  16. PMID 29185244
    .
  17. ^ "Pronectin Technology". Protelica. Retrieved 2021-09-26.
  18. PMID 27737926
    .
  19. ^ Chonira VK (2018). Engineering and characterisation of anti-progesterone OBodies (Thesis thesis). The University of Waikato.
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