Antidote
An antidote is a substance that can counteract a form of poisoning.[1] The term ultimately derives from the Greek term φάρμακον ἀντίδοτον (pharmakon antidoton), "(medicine) given as a remedy". Antidotes for anticoagulants are sometimes referred to as reversal agents.[2]
The antidotes for some particular
Some other toxins have no known antidote. For example, the poison batrachotoxin – a highly poisonous steroidal alkaloid derived from various poison dart frogs, certain beetles, and birds – has no antidote, and as a result, is often fatal if it enters the human body in sufficient quantities.
Mechanical approaches
Ingested poisons are frequently treated by the oral administration of
Techniques to identify antidotes
In early 2019, a group of researchers in Australia published the finding of a new box jellyfish venom antidote using CRISPR.[4] The technology had been used to functionally inactivate genes in human cell lines and identify the peripheral membrane protein ATP2B1, a calcium transporting ATPase, as one host factor required for box jellyfish venom cytotoxicity.[5]
List of antidotes
Agent | Indication |
---|---|
Activated charcoal with sorbitol
|
Used for many oral toxins |
Theophylline or Caffeine | Adenosine receptor agonist poisoning |
Antimuscarinic drugs (e.g. Atropine )
|
Organophosphate and carbamate insecticides, nerve agents, some poison mushrooms |
Beta blocker | Theophylline |
Calcium chloride[6] | Calcium channel blocker toxicity,[6] black widow spider bites |
Calcium gluconate[6] | Calcium channel blocker toxicity,[6] hydrofluoric acid burns |
dimercaptosuccinic acid (DMSA, succimer)
|
Heavy metal poisoning |
Cyanide antidotes (hydroxocobalamin, amyl nitrite, sodium nitrite, or thiosulfate) | Cyanide poisoning |
Cyproheptadine | Serotonin syndrome |
Deferoxamine mesylate | Iron poisoning |
Digoxin Immune Fab antibody (Digibind and Digifab)
|
Oleander ingestion [7]
|
benztropine mesylate
|
Extrapyramidal reactions associated with antipsychotics |
100% Ethanol or fomepizole | Ethylene glycol poisoning and methanol poisoning |
Flumazenil | Benzodiazepine overdose |
100% hyperbaric oxygen therapy (HBOT)
|
Carbon monoxide poisoning and cyanide poisoning |
Idarucizumab | Reversal of dabigatran etexilate, an anticoagulant
|
Insulin + Glucagon | Beta blocker poisoning and calcium channel blocker poisoning |
Leucovorin
|
Methotrexate, trimethoprim and pyrimethamine overdose |
Intralipid
|
Local Anesthetic toxicity |
Methylene blue | Treatment of conditions that cause methemoglobinemia |
Naloxone hydrochloride
|
Opioid overdose |
N-acetylcysteine
|
Paracetamol (acetaminophen) poisoning
|
Octreotide | Oral hypoglycemic agents
|
Pralidoxime chloride (2-PAM)
|
When given with Atropine: Organophosphate insecticides, nerve agents, some poison mushrooms |
Protamine sulfate | Heparin poisoning |
Prussian blue | Thallium poisoning |
Physostigmine sulfate | Anticholinergic poisoning |
Pyridoxine | Isoniazid poisoning, ethylene glycol, accidental hydrazine exposure (E.G from Gyromitra mushrooms) |
Phytomenadione (vitamin K) and fresh frozen plasma | Warfarin overdose and some (but not all) rodenticides |
Sodium bicarbonate | Aspirin, TCAs with a wide QRS[clarification needed] |
I.V Silibinin | Amatoxin ingestion |
Succimer, chemical name Dimercaptosuccinic acid (DMSA) | Lead poisoning |
See also
- Antitoxin
- Antivenom
- Snakebite
- Universal antidote
- Shapur ibn Sahl
References
- ^ "antidote" at Dorland's Medical Dictionary.
- PMID 27330657.
- PMID 1781479.
- ^ The-Crispr (2019-05-13). "Antidote to deadly jellyfish identified using CRISPR". The Crispr. Retrieved 2019-08-08.
- PMID 31040274.
- ^ a b c d "Calcium channel blocker poisoning". UpToDate. Retrieved 2019-07-09.
- ^ "Naturally Occurring Cardiac Glycoside Poisoning · California Poison Control System (CPCS)".