Antimicrobial pharmacodynamics
Antimicrobial pharmacodynamics is the relationship between the concentration of an
microbial organisms.[1] This branch of pharmacodynamics relates the concentration of an anti-infective agent to its effect, specifically to its antimicrobial effect.[2]
Concentration-dependent effects
The
minimum bactericidal concentration are used to measure in vitro activity of antimicrobial agents. They are good indicators of antimicrobial potency, but don't give any information relating to time-dependent antimicrobial killing (the so-called post antibiotic effect).[1]
Post-antibiotic effect
The post-antibiotic effect (PAE) is defined as persistent suppression of
carbapenems and agents that inhibit protein or DNA synthesis.[6]
References
- ^ ISBN 0-8247-0561-0
- S2CID 23843703.
- ^ a b c "Archived copy" (PDF). Archived from the original (PDF) on 2015-07-13. Retrieved 2008-11-13.
{{cite web}}: CS1 maint: archived copy as title (link) - PMID 1280055.
- S2CID 39240936.
- ^ Katzung basic and clinical pharmacology 13th edition 2015