Argentinian mammarenavirus
Argentinian mammarenavirus | |
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TEM and illustration of Junín virus (JUNV) particle and phylogenetic tree
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Virus classification | |
(unranked): | Virus |
Realm: | Riboviria |
Kingdom: | Orthornavirae |
Phylum: | Negarnaviricota
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Class: | Ellioviricetes |
Order: | Bunyavirales |
Family: | Arenaviridae |
Genus: | Mammarenavirus |
Species: | Argentinian mammarenavirus
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Synonyms | |
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Argentinian mammarenavirus, better known as the Junin virus or Junín virus (JUNV),[1] is an arenavirus in the Mammarenavirus genus that causes Argentine hemorrhagic fever (AHF).[2] The virus took its original name from the city of Junín, around which the first cases of infection were reported, in 1958.
Virology
Structure
Argentinian mammarenavirus is a
Genome
The Argentinian mammarenavirus genome is composed of two single-stranded RNA molecules, each encoding two different genes in an ambisense orientation. The two segments are termed 'short (S)' and 'long (L)' owing to their respective lengths. The short segment (around 3400 nucleotides in length) encodes the nucleocapsid protein and the glycoprotein precursor (GPC). The GPC is subsequently cleaved to form two viral glycoproteins, GP1 and GP2, which ultimately form the T-shaped glycoprotein spike which extends outwards from the viral envelope. [1]. The long segment (around 7200 nucleotides in length) encodes the viral polymerase and a zinc-binding protein. The virus is spread by rodents.
Disease and epidemiology
A member of the
Since the discovery of Argentinian mammarenavirus in 1958, the geographical distribution of the pathogen, although still confined to Argentina, has expanded. At the time of discovery, Argentinian mammarenavirus was confined to an area of around 15,000 km2. At the beginning of 2000, the region with reported cases grew to around 150,000 km2. The natural hosts of Argentinian mammarenavirus are rodents, particularly
Prevention and control
An investigational (in the US) vaccine (Candid1
References
- ^ "Junin virus".
- PMID 23202466.
Junín virus, the etiological agent of Argentine hemorrhagic fever, causes significant morbidity and mortality.
- Virginia Bioinformatics Institute, Virginia Tech. Archived from the originalon 2006-08-28.
- S2CID 40149042.
- ^ McKee K (1993). "Safety and Immunogenicity of a Live-Attenuated Junin (Argentine Hemorrhagic Fever) Vaccine in Rhesus Monkeys" (PDF). American Journal of Tropical Medicine and Hygiene. Archived (PDF) from the original on February 1, 2014.
- PMID 11987817.
- PMID 11987817. Archived from the original(PDF) on 2014-09-04.
- ^ Peters CJ, Buchmeir M, Rollin Pierre E, Ksiazek Thomas G (1996). Arenaviruses.
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ignored (help) - PMID 9466512.
- ^ "Banco de Recursos de Comunicación del Ministerio de Salud de la Nación | Calendario Nacional de Vacunación | 2022". bancos.salud.gob.ar. Retrieved 2023-05-25.
- ^ Pittman, Phillip R., and Stanley A. Plotkin. (2013) "41 – Biodefense and Special Pathogen Vaccines." Biodefense and Special Pathogen Vaccines - Vaccines (Sixth Edition)