Arthritis

Source: Wikipedia, the free encyclopedia.
Not to be confused with Arteritis.
For the journal, see
Arthritis (journal)
.

Arthritis
Joint pain, stiffness, redness, swelling, decreased range of motion[2][3]
ComplicationsAmplified musculoskeletal pain syndrome[4]
Types> 100, most common (osteoarthritis, rheumatoid arthritis)[5][6][7]
Risk factorsFamily history, age, sex trait, previous joint injury, obesity.[8]
TreatmentResting, applying ice or heat, weight loss, exercise, joint replacement[7]
MedicationIbuprofen, paracetamol (acetaminophen)[9]

Arthritis is a term often used to mean any disorder that affects

joint pain and stiffness.[2] Other symptoms may include redness, warmth, swelling, and decreased range of motion of the affected joints.[2][3] In some types of arthritis, other organs are also affected.[7] Onset can be gradual or sudden.[6]

There are over 100 types of arthritis.

rheumatic disease.[2]

Treatment may include resting the joint and alternating between applying ice and heat.[7][13] Weight loss and exercise may also be useful.[7][14] Recommended medications may depend on the form of arthritis.[15][9] These may include pain medications such as ibuprofen and paracetamol (acetaminophen).[9] In some circumstances, a joint replacement may be useful.[7]

Osteoarthritis affects more than 3.8% of people, while rheumatoid arthritis affects about 0.24% of people.[16] Gout affects about 1–2% of the Western population at some point in their lives.[17] In Australia about 15% of people are affected by arthritis,[18] while in the United States more than 20% have a type of arthritis.[12][19] Overall the disease becomes more common with age.[12] Arthritis is a common reason that people miss work and can result in a decreased quality of life.[9] The term is derived from arthr- (meaning 'joint') and -itis (meaning 'inflammation').[20][21]

Classification

There are several diseases where joint pain is primary, and is considered the main feature. Generally when a person has "arthritis" it means that they have one of these diseases, which include:

Joint pain can also be a symptom of other diseases. In this case, the arthritis is considered to be secondary to the main disease; these include:

An undifferentiated arthritis is an arthritis that does not fit into well-known clinical disease categories, possibly being an early stage of a definite

rheumatic disease.[51]

Signs and symptoms

Extra-articular features of joint disease[52]
Cutaneous nodules
Cutaneous vasculitis lesions
Lymphadenopathy
Oedema
Ocular inflammation
Urethritis
Tenosynovitis (tendon sheath effusions)
bursa
)
Diarrhea
Orogenital ulceration

Pain, which can vary in severity, is a common symptom in virtually all types of arthritis.

swelling, joint stiffness, redness, and aching around the joint(s).[2] Arthritic disorders like lupus and rheumatoid arthritis can affect other organs in the body, leading to a variety of symptoms.[12] Symptoms may include:[2]

It is common in advanced arthritis for significant secondary changes to occur. For example, arthritic symptoms might make it difficult for a person to move around and/or exercise, which can lead to secondary effects, such as:

Illustration of gout affected foot.

These changes, in addition to the primary symptoms, can have a huge impact on quality of life.

Disability

Arthritis is the most common cause of disability in the United States. More than 20 million individuals with arthritis have severe limitations in function on a daily basis.[12] Absenteeism and frequent visits to the physician are common in individuals who have arthritis. Arthritis can make it difficult for individuals to be physically active and some become home bound.[55] It is estimated that the total cost of arthritis cases is close to $100 billion of which almost 50% is from lost earnings. Each year, arthritis results in nearly 1 million hospitalizations and close to 45 million outpatient visits to health care centers.[56]

Decreased mobility, in combination with the above symptoms, can make it difficult for an individual to remain physically active, contributing to an increased risk of obesity, high

heart disease.[57] People with arthritis are also at increased risk of depression, which may be a response to numerous factors, including fear of worsening symptoms.[58]

Risk factors

There are common risk factors that increase a person's chance of developing arthritis later in adulthood. Some of these are modifiable while others are not.[59] Smoking has been linked to an increased susceptibility of developing arthritis, particularly rheumatoid arthritis.[60]

Diagnosis

Synovial fluid examination[61][62]
Type WBC (per mm3) % neutrophils Viscosity Appearance
Normal <200 0 High Transparent
Osteoarthritis <5000 <25 High Clear yellow
Trauma <10,000 <50 Variable Bloody
Inflammatory 2,000–50,000 50–80 Low Cloudy yellow
Septic arthritis >50,000 >75 Low Cloudy yellow
Gonorrhea ~10,000 60 Low Cloudy yellow
Tuberculosis ~20,000 70 Low Cloudy yellow
Inflammatory: Arthritis, gout, rheumatoid arthritis, rheumatic fever

Diagnosis is made by clinical examination from an appropriate health professional, and may be supported by other tests such as radiology and blood tests, depending on the type of suspected arthritis.[63] All arthritides potentially feature pain. Pain patterns may differ depending on the arthritides and the location. Rheumatoid arthritis is generally worse in the morning and associated with stiffness lasting over 30 minutes.[64]

Osteoarthritis in the left hand index finger of a 63-year-old woman.

Elements of the history of the disorder guide diagnosis. Important features are speed and time of onset, pattern of joint involvement, symmetry of symptoms, early morning stiffness, tenderness, gelling or locking with inactivity, aggravating and relieving factors, and other systemic symptoms. It may include checking joints, observing movements, examination of skin for rashes or nodules and symptoms of pulmonary inflammation. Physical examination may confirm the diagnosis or may indicate systemic disease. Radiographs are often used to follow progression or help assess severity.[65]

antinuclear factor (ANF), extractable nuclear antigen, and specific antibodies.[65]

Rheumatoid arthritis patients often have high erythrocyte sedimentation rate (ESR, also known as sed rate) or C-reactive protein (CRP) levels, which indicates the presence of an inflammatory process in the body. Anti-cyclic citrullinated peptide (anti-CCP) antibodies and rheumatoid factor (RF) are two more common blood tests. Positive results indicate the risk of rheumatoid arthritis, while negative results help rule out this autoimmune condition.

Imaging tests like X-rays, MRI scans or Ultrasounds used to diagnose and monitor arthritis. Other imaging tests for rheumatoid arthritis that may be considered include computed tomography (CT) scanning, positron emission tomography (PET) scanning, bone scanning, and dual-energy X-ray absorptiometry (DEXA).[66]

Osteoarthritis

Main article: Osteoarthritis

chondrocytes to maintain the structural integrity of cartilage.[69] More than 30 percent of women have some degree of osteoarthritis by age 65. Other risk factors for osteoarthritis include prior joint trauma, obesity, and a sedentary lifestyle.[70]

Rheumatoid arthritis

Main article: Rheumatoid arthritis
Bone erosions by rheumatoid arthritis.[71]

Rheumatoid arthritis (RA) is a disorder in which the body's own immune system starts to attack body tissues.[72] The attack is not only directed at the joint but to many other parts of the body. In rheumatoid arthritis, most damage occurs to the joint lining and cartilage which eventually results in erosion of two opposing bones. RA often affects joints in the fingers, wrists, knees and elbows, is symmetrical (appears on both sides of the body), and can lead to severe deformity in a few years if not treated. RA occurs mostly in people aged 20 and above. In children, the disorder can present with a skin rash, fever, pain, disability, and limitations in daily activities.[73] With earlier diagnosis and aggressive treatment, many individuals can lead a better quality of life than if going undiagnosed for long after RA's onset.[74][75] The risk factors with the strongest association for developing rheumatoid arthritis are the female sex, a family history of rheumatoid arthritis, age, obesity, previous joint damage from an injury, and exposure to tobacco smoke.[76][77]

Bone erosion is a central feature of rheumatoid arthritis. Bone continuously undergoes remodeling by actions of bone resorbing

synovium, caused in part by the production of pro-inflammatory cytokines and receptor activator of nuclear factor kappa B ligand (RANKL), a cell surface protein present in Th17 cells and osteoblasts.[78] Osteoclast activity can be directly induced by osteoblasts through the RANK/RANKL mechanism.[79]

Lupus

Main article: Lupus erythematosus

hair loss, kidney problems, lung fibrosis and constant joint pain.[80]

Gout

Main article: Gout

pseudogout. In the early stages, the gouty arthritis usually occurs in one joint, but with time, it can occur in many joints and be quite crippling. The joints in gout can often become swollen and lose function. Gouty arthritis can become particularly painful and potentially debilitating when gout cannot successfully be treated.[81] When uric acid levels and gout symptoms cannot be controlled with standard gout medicines that decrease the production of uric acid (e.g., allopurinol) or increase uric acid elimination from the body through the kidneys (e.g., probenecid), this can be referred to as refractory chronic gout.[82]

Comparison of types

Comparison of some major forms of arthritis[83]
Osteoarthritis Rheumatoid arthritis
Gouty arthritis
Speed of onset Months Weeks-months[84] Hours for an attack[85]
Main locations Weight-bearing joints (such as knees, hips, vertebral column) and hands Hands (
proximal interphalangeal and metacarpophalangeal joint) wrists, ankles, knees and hips
Great toe, ankles, knees and elbows
Inflammation May occur, though often mild compared to inflammation in rheumatoid arthritis Yes Yes
Radiologic
changes
  • Narrowed joint space
  • Bone erosions
  • "Punched out" bone erosions
Laboratory findings None
anti-citrullinated protein antibody
 Crystal in joints
Other features

Other

Covid-19 has been added to the list of viruses which can cause infections arthritis.[88] SARS-CoV-2 causes reactive arthritis.[88]

Psoriasis can develop into psoriatic arthritis. With psoriatic arthritis, most individuals develop the skin problem first and then the arthritis. The typical features are continuous joint pains, stiffness and swelling. The disease does recur with periods of remission but there is no known cure for the disorder. A small percentage develop a severely painful and destructive form of arthritis which destroys the small joints in the hands and can lead to permanent disability and loss of hand function.[89]

Treatment

There is no known cure for arthritis and rheumatic diseases. Treatment options vary depending on the type of arthritis and include

Joint replacement surgery may be required to repair damage, restore function, or relieve pain.[2]

Physical therapy

In general, studies have shown that physical exercise of the affected joint can noticeably improve long-term pain relief. Furthermore, exercise of the arthritic joint is encouraged to maintain the health of the particular joint and the overall body of the person.[91]

Individuals with arthritis can benefit from both physical and occupational therapy. In arthritis the joints become stiff and the range of movement can be limited. Physical therapy has been shown to significantly improve function, decrease pain, and delay the need for surgical intervention in advanced cases.[92] Exercise prescribed by a physical therapist has been shown to be more effective than medications in treating osteoarthritis of the knee. Exercise often focuses on improving muscle strength, endurance and flexibility. In some cases, exercises may be designed to train balance. Occupational therapy can provide assistance with activities. Assistive technology is a tool used to aid a person's disability by reducing their physical barriers by improving the use of their damaged body part, typically after an amputation. Assistive technology devices can be customized to the patient or bought commercially.[93]

Medications

There are several types of medications that are used for the treatment of arthritis. Treatment typically begins with medications that have the fewest side effects with further medications being added if insufficiently effective.[94]

Depending on the type of arthritis, the medications that are given may be different. For example, the first-line treatment for

non-steroidal anti-inflammatory drugs (NSAIDs) like ibuprofen. Opioids and NSAIDs may be less well tolerated.[95] However, topical NSAIDs may have better safety profiles than oral NSAIDs. For more severe cases of osteoarthritis, intra-articular corticosteroid injections may also be considered.[96]

The drugs to treat

autoimmune nature of RA, treatments may include not only pain medications and anti-inflammatory drugs, but also another category of drugs called disease-modifying antirheumatic drugs (DMARDs). csDMARDs, TNF biologics and tsDMARDs are specific kinds of DMARDs that are recommended for treatment.[97] Treatment with DMARDs is designed to slow down the progression of RA by initiating an adaptive immune response, in part by CD4+ T helper (Th) cells, specifically Th17 cells.[98] Th17 cells are present in higher quantities at the site of bone destruction in joints and produce inflammatory cytokines associated with inflammation, such as interleukin-17 (IL-17).[78]

Surgery

A number of

Arthroscopic surgery for osteoarthritis of the knee provides no additional benefit to optimized physical and medical therapy.[99]

Adaptive aids

People with hand arthritis can have trouble with simple

open source hardware to reduce patient costs.[101][102] Adaptive aids can significantly help arthritis patients and the vast majority of those with arthritis need and use them.[103]

Alternative medicine

Further research is required to determine if transcutaneous electrical nerve stimulation (TENS) for knee osteoarthritis is effective for controlling pain.[104]

Low level laser therapy may be considered for relief of pain and stiffness associated with arthritis.[105] Evidence of benefit is tentative.[106]

Pulsed electromagnetic field therapy (PEMFT) has tentative evidence supporting improved functioning but no evidence of improved pain in osteoarthritis.[107] The FDA has not approved PEMFT for the treatment of arthritis. In Canada, PEMF devices are legally licensed by Health Canada for the treatment of pain associated with arthritic conditions.[108]

Epidemiology

Arthritis is predominantly a disease of the elderly, but children can also be affected by the disease.

ethnic groups and cultures. In the United States a CDC survey based on data from 2013 to 2015 showed 54.4 million (22.7%) adults had self-reported doctor-diagnosed arthritis, and 23.7 million (43.5% of those with arthritis) had arthritis-attributable activity limitation (AAAL). With an aging population, this number is expected to increase. Adults with co-morbid conditions, such as heart disease, diabetes, and obesity, were seen to have a higher than average prevalence of doctor-diagnosed arthritis (49.3%, 47.1%, and 30.6% respectively).[110]

Disability due to musculoskeletal disorders increased by 45% from 1990 to 2010. Of these, osteoarthritis is the fastest increasing major health condition.[111] Among the many reports on the increased prevalence of musculoskeletal conditions, data from Africa are lacking and underestimated. A systematic review assessed the prevalence of arthritis in Africa and included twenty population-based and seven hospital-based studies.[112] The majority of studies, twelve, were from South Africa. Nine studies were well-conducted, eleven studies were of moderate quality, and seven studies were conducted poorly. The results of the systematic review were as follows:[112]

  • Rheumatoid arthritis: 0.1% in Algeria (urban setting); 0.6% in Democratic Republic of Congo (urban setting); 2.5% and 0.07% in urban and rural settings in South Africa respectively; 0.3% in Egypt (rural setting), 0.4% in Lesotho (rural setting)
  • Osteoarthritis: 55.1% in South Africa (urban setting); ranged from 29.5 to 82.7% in South Africans aged 65 years and older
    • Knee osteoarthritis has the highest prevalence from all types of osteoarthritis, with 33.1% in rural South Africa
  • Ankylosing spondylitis: 0.1% in South Africa (rural setting)
  • Psoriatic arthritis: 4.4% in South Africa (urban setting)
  • Gout: 0.7% in South Africa (urban setting)
  • Juvenile idiopathic arthritis: 0.3% in Egypt (urban setting)

History

Evidence of osteoarthritis and potentially inflammatory arthritis has been discovered in dinosaurs.

Ötzi, a mummy (c. 3000 BC) found along the border of modern Italy and Austria, to the Egyptian mummies c. 2590 BC.[116]

In 1715, William Musgrave published the second edition of his most important medical work, De arthritide symptomatica, which concerned arthritis and its effects.[117] Augustin Jacob Landré-Beauvais, a 28-year-old resident physician at Salpêtrière Asylum in France was the first person to describe the symptoms of rheumatoid arthritis. Though Landré-Beauvais' classification of rheumatoid arthritis as a relative of gout was inaccurate, his dissertation encouraged others to further study the disease.[118]

Terminology

The term is derived from

romanized: árthron, lit. 'joint') and -itis (from -ῖτις, -îtis, lit. 'pertaining to'), the latter suffix having come to be associated with inflammation
.

The word arthritides is the plural form of arthritis, and denotes the collective group of arthritis-like conditions.[119]

See also

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External links

Retrieved from "https://en.wikipedia.org/w/index.php?title=Arthritis&oldid=1220014958"