Aspirin/paracetamol/caffeine

Source: Wikipedia, the free encyclopedia.
Aspirin/paracetamol/caffeine
Combination of
By mouth
ATC code
Legal status
Legal status
Identifiers
JSmol)
  • O=C(Nc1ccc(O)cc1)C.O=C(O)c1ccccc1OC(=O)C.O=C2N(c1ncn(c1C(=O)N2C)C)C
  • InChI=1S/C9H8O4.C8H10N4O2.C8H9NO2/c1-6(10)13-8-5-3-2-4-7(8)9(11)12;1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2;1-6(10)9-7-2-4-8(11)5-3-7/h2-5H,1H3,(H,11,12);4H,1-3H3;2-5,11H,1H3,(H,9,10)
  • Key:BKMBGNWZSQNIKU-UHFFFAOYSA-N

Aspirin/paracetamol/caffeine is a

non-steroidal anti-inflammatory drug; paracetamol (acetaminophen), an analgesic; and caffeine, a stimulant.[1]

Adverse effects

The recommended dosing has a low risk profile when taken occasionally in a well hydrated state. As with all medications containing paracetamol (acetaminophen), concomitant use with alcohol carries a significant risk of hepatotoxicity.[2] The combination of paracetamol with aspirin also creates the risk of renal papillary necrosis if large doses are taken chronically. This is because paracetamol yields a toxic metabolite that can accumulate in the kidney while aspirin works to deplete the glutathione stores necessary to oxidize it. Additionally, chronic aspirin usage is associated with increased risk of gastrointestinal bleeding.[3]

Chemical detection

The combination of these three compounds can be detected in pharmaceutical formulations, urine and blood serum in trace quantities using

electrochemical methods.[4]

Society and culture

Brand names

The combination was first introduced as the name Triagesic in 1950 by Bristol-Myers,[

In the UK it is sold as Anadin Extra. In Germany, it is sold as dolomo, Dolopyrin AL, HA-Tabletten, Melabon K, Neuralgin, ratiopyrin, Thomapyrin Classic, Thomapyrin Intensiv,[7] in Austria as Thomapyrin, and InfluASS, in Israel as Acamol Focus, Paramol Target and Exidol, in Romania as Antinevralgic P [8] and Antinevralgic Forte,[9] and in Russia, Belarus and Eastern Europe as Citramon.[10]

References

  1. ^ a b "Acetaminophen, aspirin, and caffeine Uses, Side Effects & Warnings". Drugs.com. 19 July 2022. Retrieved 12 July 2023.
  2. ^ Haberfeld H, ed. (2019). Austria-Codex (in German). Vienna: Österreichischer Apothekerverlag. Thomapyrin-Tabletten.
  3. PMID 8546133
    .
  4. .
  5. ^ Transformación en la industria farmacéutica argentina: del liderazgo de las empresas internacionales Big Pharma al dominio de las corporaciones locales de genéricos de marca (2003-2018)
  6. ^ Olmos D (September 14, 1994). "German Firm to Reclaim Bayer Aspirin Name : Drugs: It will acquire Sterling Winthrop's over-the-counter business and recover the rights it lost after WWI". Los Angeles Times. Retrieved May 3, 2013.
  7. ^ "Rote Liste". Retrieved 2020-01-24.
  8. ^ "Antinevralgic P comprimate" (PDF). Agenția Natională a Medicamentului și a Dispozitivelor Medicale din România.
  9. ^ Blanaru C (26 June 2013). "The launch of Antinevralgic Forte – reinventing a traditional brand". Branding Business. AdHugger.
  10. ^ "International Drug Names". Drugs.com. Retrieved 2020-01-24.