Assisted zona hatching
Assisted zona hatching (AZH) is a procedure of
Efficacy
A systematic review and meta-analysis came to the result that assisted zona hatching is related to increased rates of clinical pregnancy and multiple pregnancy in women with previous repeated failure or frozen-thawed embryos.
Indications
Assisted Hatching it is not always recommended, it is mostly applied in case of:
-Implantation failure
-Advanced age
-Anomalous zona pellucida (thick, partitioned,...)
-Thawed embryos
-Blastocyst biopsy
Methods
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Mechanical assisted hatching: involves the use of micromanipulation techniques by using a needle. It's not very often used because it has a higher risk of damaging the embryo. It is also called "partial zona dissection".
Chemical assisted hatching: involves the use of specialized solutions (mostly acid, e.g. thyroid acid) in order to degrade the zona pellucida. Because it can be toxic for the embryo, it needs to be washed.
"Laser assisted hatching" (LHA): a high energy laser is used to create an opening in the zona pellucida, it is the most precise technique and safe for the embryo but it is the most expensive one.
References
- ^ IVF-infertility.com
- ^ PMID 21474527.
- PMID 30117155.
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