Astex Pharmaceuticals
| Company type | Pharmaceuticals | |
|---|---|---|
| Founded | 1999 | |
| Headquarters | European Corporate and Research headquarters in Cambridge, UK (Astex Therapeutics Limited) US Corporate and Clinical Development headquarters in Parent Otsuka Pharmaceutical |  |
| Website | astx |
Astex Pharmaceuticals ("Astex") is a biotechnology company focused on the discovery and development of drugs in oncology and diseases of the central nervous system. Astex was founded in 1999 by Sir Tom Blundell,[1][2] Chris Abell & Harren Jhoti,[3] and is located in Cambridge, England.[4][5][6][7][8]
Astex is part of the Otsuka group of companies and is a wholly-owned subsidiary of Otsuka Pharmaceutical Co. Ltd, headquartered in Tokyo, Japan.[9]
History
Astex was founded as “Astex Technology Limited” in 1999 in
In 2005, the Company changed its name to Astex Therapeutics Limited when its first product entered clinical development. In 2011, Astex Therapeutics Limited and SuperGen, Inc. (US) merged.[10] Following the acquisition, SuperGen, Inc. changed its name to Astex Pharmaceuticals, Inc., and began trading under the ticker symbol ASTX on NASDAQ.[11] The combined Astex entities were subsequently acquired by Otsuka Pharmaceutical in October 2013 for around USD $900 million, and now operate as part of the Otsuka group as wholly-owned subsidiaries.[9]
Astex currently operates from two sites:
- European Corporate and Research headquarters in Cambridge, UK (Astex Therapeutics Limited)
- US Corporate and Clinical Development headquarters in Pleasanton, California, USA (Astex Pharmaceuticals Inc.)
Research and development
Astex is focused on
Astex’s Pyramid™ platform[12] assists with the rational design of novel small molecule targeted therapies. These therapies are based on the use of biophysical techniques, principally X-ray crystallography, to screen and identify very small, low molecular weight fragments of drugs binding into the disease target of interest. Astex uses its knowledge of the 3-dimensional structure of the binding interaction between the compound and the target to design and grow from the initial fragment, adding further functionality to improve the binding interaction so that the final drug compound interacts optimally with the disease target – either through inhibition or activation.
In 2020, Astex and Taiho Pharmaceutical Co., Ltd. entered into a new partnership with Merck & Co., Inc., Kenilworth, New Jersey, USA (known as MSD outside the USA and Canada) through a subsidiary,[13] and this partnership was extended in 2021.[14]
Clinical pipeline
Astex has a pipeline of investigational compounds currently in various stages of clinical development.
Several compounds from drug discovery collaborations with Astex have been advanced by Astex’s biopharma partners into clinical trials and onto the market, including ribociclib (brand name “Kisqali”), a CDK4/CDK6 inhibitor discovered in collaboration with Novartis, subsequent to an original collaboration on FGFR inhibitors between Astex and Newcastle University, that was granted approval in the US and EU in 2017 for the treatment of breast cancer.[15] Erdafitinib (brand name “Balversa”) is an FGFR inhibitor that was discovered with Janssen Pharmaceuticals (a subsidiary of Johnson & Johnson), and received FDA market approval for the treatment of metastatic urothelial carcinoma in 2019.[16]
References
- ^ Tom Blundell: Director Archived January 1, 2015, at the Wayback Machine on OpenCorporates
- PMID 15993809.
- S2CID 23149841.
- S2CID 34803972.
- S2CID 22123557.
- PMID 16931326.
- PMID 12618177.
- PMID 16023057.
- ^ a b "Japan's Otsuka to buy Astex Pharma for about $900 million: Nikkei". Reuters. 4 September 2013. Retrieved 14 April 2021.
- ^ "SuperGen to Merge with Astex for $25M in Cash". Genetic Engineering News. 7 April 2011. Retrieved 14 April 2021.
- ^ "SuperGen, Inc. Changes Name to Astex Pharmaceuticals, Inc., Announces New Stock Ticker Symbol and New Website". BusinessWire. 12 September 2011. Retrieved 14 April 2021.
- ^ "Fragment-based approaches to drug discovery" (PDF). Sp2. June 2006. Retrieved 25 March 2021.
- ^ Brackley, Paul (9 January 2020). "Astex Pharmaceuticals and Taiho Pharmaceutical sign cancer drug deal with Merck that could be worth $2.5 billion". Cambridge Independent. Retrieved 25 March 2021.
- ^ Brackley, Paul (21 January 2021). "Astex and Taiho strike further oncology licensing deal with MSD". Cambridge Independent. Retrieved 25 March 2021.
- ^ Broderick, Jason M (14 March 2017). "FDA Approves Kisqali for Breast Cancer Subset". Cure Today. Retrieved 25 March 2021.
- ^ "FDA grants accelerated approval to erdafitinib for metastatic urothelial carcinoma". U.S. Food and Drug Administration. 12 April 2019. Retrieved 14 April 2021.