August Krogh

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August Krogh
Grenå
Died13 September 1949(1949-09-13) (aged 74)
Copenhagen
NationalityDanish
Alma materUniversity of Copenhagen
Known forDiffusing capacity for carbon monoxide
Perfusion
Krogh model
Krogh length
Krogh's principle
SpouseMarie Krogh
ChildrenErik Viggo Krogh

Ellen Rigmor Krogh
Agnes Helga Krogh

Zoophysiology
InstitutionsUniversity of Copenhagen
Thesis Frøernes Hud- og Lungerespiration  (1903)
Doctoral advisorChristian Bohr
Notable studentsTorkel Weis-Fogh

Schack August Steenberg Krogh

Krogh Principle.[5][6][7]

In 1920 August Krogh was awarded the Nobel Prize in Physiology or Medicine for the discovery of the mechanism of regulation of the capillaries in skeletal muscle.[8][9] Krogh was first to describe the adaptation of blood perfusion in muscle and other organs according to demands through opening and closing the arterioles and capillaries.[10]

Besides his contributions to medicine, Krogh was also one of the founders of what is today the Novo Nordisk company.[11]

Life

He was born in Grenaa on the peninsula of Djursland in Denmark, the son of Viggo Krogh, a shipbuilder. He was educated at the Aarhus Katedralskole in Aarhus. He attended the University of Copenhagen graduating MSc in 1899 and gaining a doctorate PhD in 1903.[12]

Krogh was a pioneer in comparative physiology. He wrote his thesis on the respiration through the skin and lungs in frogs: Respiratory Exchange of Animals, 1915. Later Krogh took on studies of water and electrolyte homeostasis of aquatic animals and he published the books: Osmotic Regulation (1939) and Comparative Physiology of Respiratory Mechanisms (1941). He contributed more than 200 research articles in international journals. He was a constructor of scientific instruments of which several had considerable practical importance, such as the spirometer and the apparatus for measuring basal metabolic rate.

Krogh began lecturing in the University of Copenhagen in 1908 and in 1916 was promoted to full professor, becoming the head of the first laboratory for animal physiology (zoophysiology) at the university.[13]

Krogh was elected an International Honorary Member of the American Academy of Arts and Sciences in 1931,[14] an International Member of the United States National Academy of Sciences in 1937,[15] and an International Member of the American Philosophical Society in 1941.[16]

Krogh and his wife Marie, scientist in her own right, brought insulin to Denmark shortly after its discovery in 1922 by Frederick Banting and Charles Best.[17] Marie, a doctor who had patients with type 1 diabetes, was herself suffering from type 2 diabetes and was naturally very interested in the disease.[11] Together with doctor Hans Christian Hagedorn, August and Marie Krogh founded Nordisk Insulinlaboratorium, where Krogh made decisive contributions to establishing a Danish production of insulin by ethanol extraction of the hormone from the pancreatic glands of pigs.[11]

In the 1930s, Krogh worked with two other Nobel prizewinners, the radiochemist George de Hevesy and the physicist Niels Bohr on the permeability of membranes to heavy water and radioactive isotopes, and together, they managed to obtain Denmark's first cyclotron for experiments on animal and plant physiology as well as in dental and medical work.[13]

Publications

  • The Respiratory Exchange of Animals and Man (1916)
  • Osmotic Regulation in Aquatic Animals (1939)
  • The Comparative Physiology of Respiratory Mechanisms (1941)

Family

He married Marie Krogh (née Jørgensen, 1874–1943) in 1905. She was a renowned scientist in her own right and much of August Krogh's work was carried out in close collaboration with her.[10]

August and Marie had four children, the youngest of whom, Bodil, was born in 1918. She too was a physiologist, and became the first woman president of the American Physiological Society in 1975.[18] Bodil married another eminent physiologist, Knut Schmidt-Nielsen.[19][20]

Legacy

Torkel Weis-Fogh, an eminent pioneer on the study of insect flight, was a student of August Krogh's. Together they wrote a classic paper on that subject in 1951.[21]

Krogh's name is preserved in two items now named for him:

  • diffuse to, based on cellular consumption of the nutrients.[22][23]
  • Krogh's principle, that "for... a large number of problems there will be some animal of choice, or a few such animals, on which it can be most conveniently studied."[24]

Further reading

References

  1. S2CID 161131285
    .
  2. PMID 15442251
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  3. PMID 15413515
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  4. PMID 15420871
    .
  5. PMID 5335475
    .
  6. PMID 16739398
    .
  7. PMID 14901880
    .
  8. PMID 17877986
    .
  9. PMID 4870667
    .
  10. ^ a b "August Krogh - Facts". Nobelprize.org. Retrieved 2 August 2016.
  11. ^ a b c "The Founders". Novo Nordisk. Archived from the original on 16 July 2016. Retrieved 2 August 2016.
  12. ISBN 0-902-198-84-X
    .
  13. ^ a b "George de Hevesy: Explosion of new knowledge". Niels Bohr Institute. 2014-09-11. Retrieved 2 August 2016.
  14. ^ "August Krogh". American Academy of Arts & Sciences. Retrieved 2023-04-26.
  15. ^ "August Krogh". www.nasonline.org. Retrieved 2023-04-26.
  16. ^ "APS Member History". search.amphilsoc.org. Retrieved 2023-04-26.
  17. ISBN 9780195090994
    .
  18. ^ Dantzler, William H. (July 2015). "Obituary Bodil Schmidt-Nielsen (1918-2015) 48th APS President". Archived from the original on December 22, 2015. Retrieved December 17, 2015.
  19. ^ Living history of physiology: Bodil Schmidt-Nielsen (Prof. William Dantzler. University of Arizona) [1] Archived 2008-12-26 at the Wayback Machine
  20. ^ 48th APS President (1975-1976)Bodil M. Schmidt-Nielsen (American Physiological Society) "© the American Physiological Society - Bodil M. Schmidt-Nielsen". Archived from the original on 2009-11-21. Retrieved 2009-11-03.
  21. doi:10.1242/jeb.28.3.344
    .
  22. ^ Fournier, R. L. Basic Transport Phenomena in Biomedical Engineering. Taylor & Francis, London, 1999.
  23. ^ Choi et al. Microfluidic scaffolds for tissue engineering. Nature Materials (2007) vol. 6 pp. 908-915
  24. ^ Bernard, Claude. Introduction à l'étude de la médecine expérimentale, J.B. Baillière et Fils, Libraires de L'Académie Impériale de Médecine, 1865. pp. 400

External links

Wikiquote has quotations related to August Krogh.
  • August Krogh on Nobelprize.org Edit this at Wikidata including the Nobel Lecture on December 11, 1920 A Contribution to the Physiology of the Capillaries
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