Azim Surani

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Azim Surani

Mendel Medal (2022)
Scientific career
InstitutionsUniversity of Cambridge
ThesisModulation of Implanting Rat Blastocysts to Macromolecular Secretions of the Uterus (1975)
Doctoral advisorRobert Edwards
Doctoral studentsKat Arney[2]
Other notable studentsAnne Ferguson-Smith (postdoc)[3]
Websitewww.gurdon.cam.ac.uk/research/surani

Azim Surani

CBE FRS FMedSci[1] (born 1945 in Kisumu, Kenya) is a Kenyan-British developmental biologist who has been Marshall–Walton Professor at the Wellcome Trust/Cancer Research UK Gurdon Institute at the University of Cambridge since 1992, and Director of Germline and Epigenomics Research since 2013.[4][5]

Education

Surani was educated at

Plymouth University (BSc),[when?] the University of Strathclyde (MSc)[6] and the University of Cambridge (PhD) where his research was supervised by Robert Edwards, who later won the Nobel Prize in Physiology or Medicine.[1][6][7]

Career and research

Surani co-discovered mammalian genomic imprinting with Davor Solter[8] in 1984, and subsequently examined its mechanism and the functions of imprinted genes.[1] He later established the genetic basis for germ cell specification, using a single-cell analysis in mice.[1] This genetic network also initiates the unique resetting of the germline epigenome, including comprehensive erasure of DNA methylation towards re-establishing full genomic potency.[1] Epigenetic modifications and re-establishments of imprints then generate functional differences between parental genomes whilst aberrant imprints contribute to human disease.[1]

Surani's research is identifying key regulators of human

noncoding RNAs, and the potential for transgenerational epigenetic inheritance in mammals.[1]

Awards and honours

Surani has received several awards for his work including the Royal Medal (2010), the Gabor Medal (2001) and the Mendel Lectures (2010).[citation needed] He received the Canada Gairdner International Award, with Davor Solter, "For the discovery of mammalian genomic imprinting that causes parent-of-origin specific gene expression and its consequences for development and disease."[9] He won the Rosenstiel Award in 2006, with Solter and Mary Lyon, for "pioneering work on epigenetic gene regulation in mammalian embryos".[10]

External links

References

  1. ^ a b c d e f g h i "Professor Azim Surani". royalsociety.org. London: Royal Society. 1990. Archived from the original on 17 November 2015. One or more of the preceding sentences incorporates text from the royalsociety.org website where:

    "All text published under the heading 'Biography' on Fellow profile pages is available under Creative Commons Attribution 4.0 International License." --"Terms, conditions and policies | Royal Society". Archived from the original on 11 November 2016. Retrieved 30 August 2017.{{cite web}}: CS1 maint: bot: original URL status unknown (link)
  2. OCLC 894595629
    .
  3. S2CID 4233463. Closed access icon
  4. ^ Azim Surani publications indexed by the Scopus bibliographic database. (subscription required)
  5. ^ "Azim Surani — The Gurdon Institute". Gurdon.cam.ac.uk. Retrieved 29 August 2017.
  6. ^ a b McFarlane, Alan (2009). "Azim Surani interviewed by Alan Macfarlane". alanmacfarlane.com. Archived from the original on 6 March 2016.
  7. OCLC 500574338
    .
  8. PMID 30343680
    .
  9. ^ "Gairdner Awards 2018 Laureates | Gairdner Foundation". Gairdner Foundation. Retrieved 21 September 2018.
  10. ^ "Past Winners". Brandeis University. Retrieved 25 March 2019.
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