BATF (gene)

Source: Wikipedia, the free encyclopedia.
BATF
Identifiers
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_006399

NM_016767

RefSeq (protein)

NP_006390

NP_058047

Location (UCSC)Chr 14: 75.52 – 75.55 MbChr 12: 85.73 – 85.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Basic leucine zipper transcription factor, ATF-like, also known as BATF, is a protein which in humans is encoded by the BATF gene.[5][6][7]

Function

The protein encoded by this gene is a nuclear basic leucine zipper (

Jun family of proteins. This protein is thought to be a negative regulator of AP-1/ATF transcriptional events.[7]

Mice without the BATF gene (BATF knockout mice) lacked a type of inflammatory immune cell (Th17) and were resistant to conditions that normally induces an autoimmune condition similar to multiple sclerosis.[8]

Interactions

BATF (gene) has been shown to

interact with IFI35.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000156127 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034266 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. PMID 8570175
    .
  6. .
  7. ^ a b "Entrez Gene: BATF basic leucine zipper transcription factor, ATF-like".
  8. PMID 19578362
    .
  9. PMID 8954125
    .

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.