BCL11B
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| Location (UCSC) | Chr 14: 99.17 – 99.27 Mb | Chr 12: 107.88 – 107.97 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
B-cell lymphoma/leukemia 11B is a protein that in humans is encoded by the BCL11B gene.[5][6][7]
Gene location
BCL11B is located on human chromosome 14p32.2.[8] The mouse analogue is called Rit1 or Bcl11b and is located on mouse chromosome 12.[9]
Function
This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. The specific function of this gene has not yet been determined, but it could also be involved in some malignancies. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported.[7]
Research suggests that BCL11B is crucial for
ameloblasts (the cells that produce tooth enamel) to form and work properly.[10]
Interactions
BCL11B has been shown to
Pathology
BCL11B is closely connected with immune regulation and for so its mutation can lead to a
Research projects
A
intestines.[15]
Bcl11b (
malignant growth for example in case of mouse lymphomas. That is suspected to be caused by interaction with p53, a well-known tumor suppressor gene.[9]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000127152 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048251 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 11719382.
- PMID 16950772.
- ^ a b "Entrez Gene: BCL11B B-cell CLL/lymphoma 11B (zinc finger protein)".
- ^ "OMIM Entry - * 606558 - B-CELL CLL/LYMPHOMA 11B; BCL11B". www.omim.org. Retrieved 2019-07-29.
- ^ PMID 12565905.
- PMID 19251658.*Lay summary in: "Gene could allow lab-grown teeth". BBC News. February 24, 2009.
- PMID 10744719.
- OCLC 1035016036.
- ^ PMID 27959755.
- ^ PMID 29985992.
- PMID 21875956.
Further reading
- Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M (April 2000). "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors". The Journal of Biological Chemistry. 275 (14): 10315–22. PMID 10744719.
- Avram D, Fields A, Senawong T, Topark-Ngarm A, Leid M (December 2002). "COUP-TF (chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding protein". The Biochemical Journal. 368 (Pt 2): 555–63. PMID 12196208.
- Wakabayashi Y, Inoue J, Takahashi Y, Matsuki A, Kosugi-Okano H, Shinbo T, et al. (February 2003). "Homozygous deletions and point mutations of the Rit1/Bcl11b gene in gamma-ray induced mouse thymic lymphomas". Biochemical and Biophysical Research Communications. 301 (2): 598–603. PMID 12565905.
- Rohr O, Lecestre D, Chasserot-Golaz S, Marban C, Avram D, Aunis D, et al. (May 2003). "Recruitment of Tat to heterochromatin protein HP1 via interaction with CTIP2 inhibits human immunodeficiency virus type 1 replication in microglial cells". Journal of Virology. 77 (9): 5415–27. PMID 12692243.
- Senawong T, Peterson VJ, Avram D, Shepherd DM, Frye RA, Minucci S, Leid M (October 2003). "Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression". The Journal of Biological Chemistry. 278 (44): 43041–50. PMID 12930829.
- Bezrookove V, van Zelderen-Bhola SL, Brink A, Szuhai K, Raap AK, Barge R, et al. (February 2004). "A novel t(6;14)(q25-q27;q32) in acute myelocytic leukemia involves the BCL11B gene". Cancer Genetics and Cytogenetics. 149 (1): 72–6. PMID 15104287.
- MacLeod RA, Nagel S, Drexler HG (August 2004). "BCL11B rearrangements probably target T-cell neoplasia rather than acute myelocytic leukemia". Cancer Genetics and Cytogenetics. 153 (1): 88–9. PMID 15325104.
- Przybylski GK, Dik WA, Wanzeck J, Grabarczyk P, Majunke S, Martin-Subero JI, et al. (February 2005). "Disruption of the BCL11B gene through inv(14)(q11.2q32.31) results in the expression of BCL11B-TRDC fusion transcripts and is associated with the absence of wild-type BCL11B transcripts in T-ALL". Leukemia. 19 (2): 201–8. S2CID 27146016.
- Cismasiu VB, Adamo K, Gecewicz J, Duque J, Lin Q, Avram D (October 2005). "BCL11B functionally associates with the NuRD complex in T lymphocytes to repress targeted promoter". Oncogene. 24 (45): 6753–64. S2CID 14198939.
- Marban C, Suzanne S, Dequiedt F, de Walque S, Redel L, Van Lint C, et al. (January 2007). "Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing". The EMBO Journal. 26 (2): 412–23. PMID 17245431.
- Nagel S, Scherr M, Kel A, Hornischer K, Crawford GE, Kaufmann M, et al. (February 2007). "Activation of TLX3 and NKX2-5 in t(5;14)(q35;q32) T-cell acute lymphoblastic leukemia by remote 3'-BCL11B enhancers and coregulation by PU.1 and HMGA1". Cancer Research. 67 (4): 1461–71. PMID 17308084.
- Kamimura K, Mishima Y, Obata M, Endo T, Aoyagi Y, Kominami R (August 2007). "Lack of Bcl11b tumor suppressor results in vulnerability to DNA replication stress and damages". Oncogene. 26 (40): 5840–50. S2CID 29677572.
External links
- BCL11B+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Human ATL1 genome location and ATL1 gene details page in the UCSC Genome Browser.
- Human BCL11B genome location and BCL11B gene details page in the UCSC Genome Browser.
- Human RIT1 genome location and RIT1 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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