BDPC
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| Melting point | 208 to 210 °C (406 to 410 °F) |
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BDPC (systematic name 4-(4-bromophenyl)-4-(dimethylamino)-1-(2-phenylethyl)cyclohexanol; also known as bromadol) is a potent fully synthetic opioid with a distinctive arylcyclohexylamine chemical structure. It was developed by Daniel Lednicer at Upjohn in the 1970s.[1] Initial studies estimated that it was around 10,000 times the potency of morphine in animal models.[2] However, later studies using more modern techniques assigned a value of 504 times the potency of morphine for the more active trans-isomer.[3] This drug was first seized along with three kilograms of acetylfentanyl in an April 25, 2013 police action in Montreal, Canada,[4] and has reportedly continued to be available on the designer drug market internationally.[5][6] Analogues where the para-bromine is replaced by chlorine or a methyl group retain similar activity, while the meta-hydroxyl derivative demonstrated robust antagonist activity.[7][8]
See also
References
- ^ US 4366172, Lednicer, Daniel, "4-Amino-cyclohexanols, their pharmaceutical compositions and methods of use", issued 1982-12-28, assigned to Upjohn Company
- PMID 513062.
- PMID 12738037.
- ^ "Extremely potent painkiller hits Montreal black market". CBC News. May 13, 2013.
- PMID 30636980.
- S2CID 220881657.
- PMID 7265128.
- PMID 7265120.