BW373U86

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BW373U86
Clinical data
Other names(+)-BW373U86
Identifiers
  • 4-[(R)-[(2S,5R)-2,5-dimethyl-4-prop-2-enylpiperazin-1-yl]-(3-hydroxyphenyl)methyl]-N,N-diethylbenzamide
JSmol)
  • CCN(CC)C(=O)C1=CC=C(C=C1)C(C2=CC(=CC=C2)O)N3CC(N(CC3C)CC=C)C
  • InChI=1S/C27H37N3O2/c1-6-16-29-18-21(5)30(19-20(29)4)26(24-10-9-11-25(31)17-24)22-12-14-23(15-13-22)27(32)28(7-2)8-3/h6,9-15,17,20-21,26,31H,1,7-8,16,18-19H2,2-5H3/t20-,21+,26-/m1/s1 ☒N
  • Key:LBLDMHBSVIVJPM-YZIHRLCOSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

(+)-BW373U86 is an opioid analgesic drug used in scientific research.[1][2]

BW373U86 is a

δ-opioid receptor, with approximately 15× stronger affinity for the δ-opioid than the μ-opioid receptor.[3] It has potent analgesic and antidepressant effects in animal studies.[4][5] In studies on rats, BW373U86 appears to protect heart muscle cells from apoptosis in conditions of ischemia (oxygen deprivation, such as in heart attack). The mechanism for this is complex and may be separate from its delta agonist effects.[6][7][8]

References

  1. PMID 9057856
    .
  2. PMID 11300879
    .
  3. PMID 8246159
    .
  4. S2CID 25978130
    .
  5. PMID 12007745
    .
  6. PMID 11448134
    .
  7. PMID 15120566
    .
  8. S2CID 28128170
    .
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