Basophilic stippling
Basophilic stippling, also known as punctate basophilia, is the presence of numerous
Perls' acid ferrocyanide stain for iron (i.e. no iron in basophilic stippling).[1] Basophilic stippling is indicative of disturbed erythropoiesis. It can also be found in some normal individuals.[2]
Associated conditions
- Thalassemia[3] (β-thalassemia Minor (i.e. Trait) & Major, and α-thalassemia, only when 3 gene loci defective: (--/-α))
- Severe megaloblastic anemia
- Hemolytic anemia
- Sickle-cell anemia
- Pyrimidine 5' nucleotidase deficiency[4]
- Alcoholism[5]
- Myelodysplastic syndromes
- Sideroblastic anemia[6]
- Congenital dyserythropoietic anemia[7]
- Primary myelofibrosis
- Leukemia[8]
- Erythroleukemia[9]
- Hemorrhage, e.g. from gastrointestinal tract
- CPD-choline phosphotransferase deficiency[10]
- Unstable hemoglobins
- Altered hemoglobin biosynthesis
References
- ISBN 978-1-264-94662-4.
- PMID 6202140.
- ISBN 9780781770231.[page needed]
- PMID 10504847.
- ISBN 978-1416066835.
- ISBN 978-1416030065.
- ISBN 978-1437735895.[page needed]
- ISBN 978-1416066835.[page needed]
- ISBN 978-1416066835.[page needed]
- ISBN 978-0702045356.[page needed]
- ISBN 9780323327169.[page needed]
- ISBN 9780781732741.[page needed]