Bcl-2-associated death promoter

Source: Wikipedia, the free encyclopedia.
BAD
Available structures
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_032989
NM_004322

NM_007522
NM_001285453

RefSeq (protein)

NP_004313
NP_116784

NP_001272382
NP_031548

Location (UCSC)Chr 11: 64.27 – 64.28 MbChr 19: 6.92 – 6.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse
Pro-apoptotic Bcl-2 protein, BAD
complex of bcl-xl with peptide from bad
Identifiers
SymbolBcl-2_BAD
PfamPF10514
InterProIPR018868
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

The BCL2 associated agonist of cell death

heterodimer
with anti-apoptotic proteins and prevent them from stopping apoptosis.

Mechanism of action

Bax/Bak are believed to initiate apoptosis by forming a pore in the mitochondrial outer membrane that allows cytochrome c to escape into the cytoplasm and activate the pro-apoptotic caspase cascade. The anti-apoptotic Bcl-2 and Bcl-xL proteins inhibit cytochrome c release through the mitochondrial pore and also inhibit activation of the cytoplasmic caspase cascade by cytochrome c.[8]

Dephosphorylated BAD forms a heterodimer with

Bax-triggered apoptosis.[9] BAD phosphorylation is thus anti-apoptotic, and BAD dephosphorylation (e.g., by Ca2+-stimulated Calcineurin) is pro-apoptotic. The latter may be involved in neural diseases such as schizophrenia.[10]

Interactions

Overview of signal transduction pathways involved with apoptosis.

Bcl-2-associated death promoter has been shown to

interact
with:

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000002330 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024959 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "BAD BCL2 associated agonist of cell death [Homo sapiens (Human)] - Gene - NCBI".
  6. PMID 12404123
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  8. ^ Helmreich, E.J.M. (2001) The Biochemistry of Cell Signalling, pp. 238-43
  9. ^ E.J.M. (2001) The Biochemistry of Cell Signalling, pp. 242
  10. ^ Foster, T.C. et al. (2001) J. Neurosci. 21, 4066-4073, "Calcineurin Links Ca++ Dysregulation with Brain Aging"(
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    PMID 15694340
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Further reading

External links