Becaplermin
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Becaplermin (brand name Regranex) is a
Medical uses
The drug is used for the treatment of
The amount of becaplermin to be applied will vary depending upon the size of the ulcer area. Becaplermin should be stored in the refrigerator.[1] Analysis of healing human wounds showed that PDGF-BB induces fibroblast proliferation and differentiation and was found to increase healing in patients with decreased healing capacity, such as people living with diabetes. [5]
Contraindications
Becaplermin must not be used at the site of a skin cancer.[6]
Adverse effects
The most common side effects in clinical studies were
A boxed warning has been added to the safety label to describe an increase rate of death from cancer when three or more tubes are used.[7] Regranex should be used with caution in patients with known malignancy.[1]
References
- ^ a b c d "REGRANEX Gel Highlights of Prescribing Information" (PDF). Smith & Nephew, Inc. Archived from the original (PDF) on 26 August 2016.
- S2CID 28408255.
- S2CID 20595962.
- PMID 16464208.
- ^ Heldin CH, Westermark B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev. 1999;79:1283-1316.
- ^ a b FDA Professional Drug Information for Regranex.
- ^ Waknine Y (9 June 2008). "Diabetic Ulcer Gel Gets Black Box Warning". Medscape.