Beclometasone
Clinical data | |
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Trade names | Qvar, Beconase AQ, others |
Other names | Beclometasone dipropionate; beclomethasone dipropionate, beclomethasone (USAN US) |
AHFS/Drugs.com | Monograph |
MedlinePlus | a681047 |
License data | |
Pregnancy category |
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Routes of administration | Inhalation, nasal, topical |
ATC code | |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | Converted to beclometasone-17-monopropionate (17-BMP) during absorption |
Protein binding | 87% of 17-BMP to albumin and transcortin |
Metabolism | By esterase enzymes found in most tissues |
Elimination half-life | 2.8 hours |
Excretion | Biliary (60%), renal (12%) |
Identifiers | |
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JSmol) | |
Melting point | 117 to 120 °C (243 to 248 °F) (dec.) |
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Beclometasone or beclomethasone, also known as beclomethasone dipropionate, and sold under the brand name Qvar among others, is a steroid medication.[1] It is available as an inhaler, cream, pills, and nasal spray.[2] The inhaled form is used in the long-term management of asthma.[1] The cream may be used for dermatitis and psoriasis.[3] The pills have been used to treat ulcerative colitis.[4] The nasal spray is used to treat allergic rhinitis and nasal polyps.[5]
Common side effects with the inhaled form include
Beclomethasone dipropionate was first patented in 1962 and used medically in 1972.[7] It was approved for medical use in the United States in 1976.[1] It is on the World Health Organization's List of Essential Medicines.[8] In 2021, it was the 268th most commonly prescribed medication in the United States, with more than 1 million prescriptions.[9][10]
Side effects
Common side effects with the inhaled form include
Occasionally, it may cause a cough upon inhalation. Deposition on the tongue and throat may promote oral candidiasis, which appears as a white coating, possibly with irritation.[11][12][13] This may usually be prevented by rinsing the mouth with water after using the inhaler. Other
Nasal corticosteroids may be associated with
Pharmacology
Beclometasone is mainly a glucocorticoid.[1] Glucocorticoids are corticosteroids that bind to the glucocorticoid receptor[15] that is present in almost every vertebrate animal cell. The activated glucocorticoid receptor-glucocorticoid complex up-regulates the expression of anti-inflammatory proteins in the nucleus (a process known as transactivation) and represses the expression of proinflammatory proteins in the cytosol by preventing the translocation of other transcription factors from the cytosol into the nucleus (transrepression).[16]
Glucocorticoids are part of the feedback mechanism in the immune system which reduces certain aspects of immune function, such as inflammation.
Names
Beclometasone dipropionate is the
Clenil, Qvar, Cortis are brandnames for the inhalers; Beconase, Alanase, Vancenase, Qnasl for the nasal spray or aerosol.
References
- ^ a b c d e f g h i "Beclomethasone Dipropionate". The American Society of Health-System Pharmacists. Archived from the original on 8 December 2015. Retrieved 2 December 2015.
- ^ "List of products: Beclometasone dipropionate". MHRA. Archived from the original on 8 December 2015. Retrieved 6 December 2015.
- ^ "Beclometasone dipropionate 0.25 mg/g Cream" (PDF). MHRA. Archived from the original (PDF) on 8 December 2015. Retrieved 6 December 2015.
- ^ a b c d e "Clipper" (PDF). MHRA. Archived from the original (PDF) on 8 December 2015. Retrieved 6 December 2015.
- ^ "Beclomethasone Dipropionate eent". The American Society of Health-System Pharmacists. Archived from the original on 8 December 2015. Retrieved 2 December 2015.
- ^ ISBN 9781284057560.
- ISBN 9780815518563. Archivedfrom the original on 8 December 2015.
- hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
- ^ "Beclomethasone - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
- PMID 1259918.
- PMID 3339197.
- PMID 12839324.
- PMID 9331207.
- ISBN 978-1617287589.
- S2CID 5744727.
- ISBN 978-1-4757-2085-3.
- ISBN 978-3-88763-075-1.
- ISBN 978-94-011-4439-1. Archivedfrom the original on 12 January 2023. Retrieved 17 March 2019.
- ISBN 978-3-7692-2114-5. Archivedfrom the original on 12 January 2023. Retrieved 17 March 2019.
- ^ "Beclometasone". drugs.com. Archived from the original on 18 January 2018. Retrieved 17 March 2019.