Bemegride
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| Trade names | Migimide, others |
| Other names | Methetharimide β,β-methylethylglutarimide |
| AHFS/Drugs.com | International Drug Names |
| ATC code | |
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| Identifiers | |
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JSmol) | |
| Melting point | 127 °C (261 °F) |
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Bemegride (trademarked as Megimide) is a central nervous system stimulant.[1] The drug was first made in 1911.[2] It has been used in hypnotic overdose.[1]
As with other chemoreceptor agonists, it is a potent
emetic at doses above those normally used in management of barbiturate overdose although emesis and aspiration
are a concern during treatment.
It is a controlled substance in some countries.[1]
Animal use
Bemegride is also used to induce convulsions in experimental animals.[3]
Synthesis
The original synthesis involves first the condensation of
carboxamide
under strongly basic conditions. Decarboxylative hydrolysis of 6 then leads to bemegride 7.
John Bodkin Adams case
Bemegride was the drug which suspected
Gertrude Hullett. Hullett took an overdose of barbiturates on 19 July 1956 but Adams only gave her a single 10cc dose of bemegride three days later on the 22nd, despite having acquired 100cc for her treatment. Hullett died the next day on 23 July 1956. Adams was charged but never tried for her murder.[4]
References
- ^ ISBN 3527306730.
- ^ .
- ^ Definition: bemegride from Online Medical Dictionary
- ISBN 1-904027-19-9