Benazepril
Clinical data | |
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Pronunciation | /bəˈnæzəprɪl/ |
Trade names | Lotensin, others |
AHFS/Drugs.com | Monograph |
MedlinePlus | a692011 |
License data |
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By mouth | |
ATC code | |
Legal status | |
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Pharmacokinetic data | |
Protein binding | 96.7% |
Metabolism | Liver glucuronidation |
Elimination half-life | 10-11 hours |
Excretion | Kidney and bile duct |
Identifiers | |
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Benazepril, sold under the brand name Lotensin among others, is a
benazepril/amlodipine.[2]
Common side effects include feeling tired,
high blood potassium, and angioedema.[2] Use in pregnancy may harm the baby, while use when breastfeeding may be safe.[3] It is an ACE inhibitor and works by decreasing renin-angiotensin-aldosterone system activity.[2]
Benazepril was patented in 1981 and came into medical use in 1990. It is available as a
generic medication.[2] In 2021, it was the 147th most commonly prescribed medication in the United States, with more than 3 million prescriptions.[4][5]
Medical uses
Lotensin is
Side effects
The most common side effects patients experience are a headache or a chronic cough. The chronic cough develops in about 20% of people treated.[6]
Contraindications
Benazepril can harm the fetus.[7]
Dosage forms
It is also available in combination with hydrochlorothiazide, under the brand name Lotensin HCT, and with amlodipine (Lotrel).
Veterinary uses
Under the brand names Fortekor (
chronic kidney failure in cats and dogs.[10]
References
- ^ a b "Lotensin- benazepril hydrochloride tablet". DailyMed. 21 January 2019. Retrieved 11 February 2024.
- ^ a b c d e f g h i "Benazepril Hydrochloride Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 3 March 2019.
- ^ "Benazepril Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.
- ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
- ^ "Benazepril - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
- ^ Dykewicz MS (April 2004). "Cough and Angioedema From Angiotensin-Converting Enzyme Inhibitors: New Insights Into Mechanisms and Management". Medscape. Retrieved 2 April 2014.
- ^ "Lotensin package insert" (PDF). U.S. Food and Drug Administration (FDA). 2011. Retrieved 9 December 2020.
- PMID 8599524.
- PMID 19572914.
- ^ "Fortekor Flavor Tabs (5 mg) (Canada) for Animal Use". Drugs.com. Retrieved 9 December 2020.