Dermatofibroma

Source: Wikipedia, the free encyclopedia.
(Redirected from
Benign fibrous histiocytoma
)
Dermatofibroma
Other namesDermal dendrocytoma,[1] Dermatofibroma,[2] Fibrous dermatofibroma,[2] Fibrous histiocytoma,[2] Fibroma simplex,[1] Nodular subepidermal fibrosis,[1] and Sclerosing hemangioma[1])
Histopathology of dermatofibroma, with basilar hyperpigmentation of the overlying epidermis (top right), and spindled fibroblasts with collagen entrapment. HE stain.
SpecialtyOncology Edit this on Wikidata

A dermatofibroma, or benign fibrous histiocytomas, is a

benign nodule in the skin, typically on the legs, elbows or chest of an adult.[3] It is usually painless.[3]

It usually ranges from 0.2cm to 2cm in size but larger examples have been reported.

medicines that weaken immunity.[3]

It is usually diagnosed by its appearance, but a biopsy may be required.

dermatofibrosis lenticularis disseminata may look similar.[3] Usually no treatment is needed.[3] It can remain unchanged for years but can resolve spontaneously.[3]

Signs and symptoms

Dermatofibromas

itching and tenderness can occur. Dermatofibromas can be found anywhere on the body, but most often they are found on the legs and arms.[5] They occur more often in women; the male to female ratio is about 1:4.[6]
The age group in which they most commonly occur is 20 to 45 years.

Some physicians and researchers believe dermatofibromas form as a reaction to previous injuries such as insect bites or thorn pricks.

fibroblasts. Dermatofibromas are classed as benign skin lesions, meaning they are completely harmless, though they may be confused with a variety of subcutaneous tumours.[7] Deep penetrating dermatofibromas may be difficult to distinguish, even histologically, from rare malignant fibrohistocytic tumours like dermatofibrosarcoma protuberans.[8]

Dermatofibromas typically have a positive buttonhole sign, or central dimpling in the center.[9]

Diagnosis

Immunohistochemical staining

Neoplasm CD34[1]
Stromelysin-3[10]
Factor XIIIa[6]
Dermatofibroma - + +
Dermatofibrosarcoma protuberans + - -

See also

References

  1. ^
    ISBN 978-1-4160-2999-1.[page needed
    ]
  2. ^
    ISBN 978-0-07-138076-8
    .
  3. ^
    ISBN 978-0-323-54753-6
    .
  4. ^ "Dermatofibroma | Genetic and Rare Diseases Information Center (GARD) – an NCATS Program". rarediseases.info.nih.gov. Retrieved 2018-04-17.
  5. ^ "dermatofibroma" at Dorland's Medical Dictionary
  6. ^ a b c Dermatofibroma at eMedicine
  7. PMID 21747634
    .
  8. PMID 16740036
    .
  9. ISBN 9780199657582
    .
  10. S2CID 7049937
    .

External links

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