Benzphetamine

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Benzphetamine
Clinical data
Trade namesDidrex, Recede
Other namesN-benzyl-N-methylamphetamine
AHFS/Drugs.comProfessional Drug Facts
License data
Dependence
liability		High[1]
Routes of
administration		By mouth
ATC code
  • None
Legal status
Legal status
Pharmacokinetic data
Protein binding75–99%
Elimination half-life4-6 hours
Identifiers
  • (2S)-N-Benzyl-N-methyl-1-phenylpropan-2-amine
JSmol)
  • N(C)(Cc1ccccc1)[C@@H](C)Cc2ccccc2
  • InChI=1S/C17H21N/c1-15(13-16-9-5-3-6-10-16)18(2)14-17-11-7-4-8-12-17/h3-12,15H,13-14H2,1-2H3/t15-/m0/s1 checkY
  • Key:YXKTVDFXDRQTKV-HNNXBMFYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Benzphetamine (brand name Didrex) is a

dextromethamphetamine.[3][4][5]

Benzphetamine is an anorectic, primarily promoting weight loss through reduced appetite. It also slightly increases metabolism.

Pharmacology

Benzphetamine is a

sympathomimetic amine and is classified as an anorectic.[6] The drug's main function is to reduce appetite, which in turn reduces caloric intake.[medical citation needed
]

Although the mechanism of action of the sympathomimetic appetite suppressants in the treatment of obesity is not fully known, these medications have pharmacological effects similar to those of amphetamines.

VMAT2 and inhibiting its function, causing a release of these neurotransmitters into the synaptic cleft through their reuptake transporters. Tachyphylaxis and tolerance have been demonstrated with all drugs of this class.[medical citation needed
]

Benzphetamine has a

half-life of 4–6 hours.[7]

Contraindications

Benzphetamine is contraindicated in patients with advanced arteriosclerosis, symptomatic cardiovascular disease, moderate to severe hypertension, hyper-thyroidism, known hypersensitivity or idiosyncrasy to sympathomimetic amines, and glaucoma, or who have recently used a MAOI. Benzphetamine should not be given to patients who are in an agitated state or who have a history of drug abuse.[8]

Controlled substance classification

Benzphetamine is unique in its classification as a Schedule III drug in the United States. (Most members of the amphetamine family are classified in the more highly regulated Schedule II.) Benzphetamine is metabolized by the human body into amphetamine and methamphetamine, making it one of a number of drugs to undergo in vivo conversion to a substance of higher addiction and abuse potential.[9]

References

  1. ^ "Benzphetamine". Toxnet. Archived from the original on 2018-11-01.
  2. ^ Anvisa (2023-07-24). "RDC Nº 804 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 804 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-07-25). Archived from the original on 2023-08-27. Retrieved 2023-08-27.
  3. ISBN 978-1-934863-59-6
    .
  4. PMID 9681333
    .
  5. doi:10.1093/jat/2.6.241
    .
  6. PMID 10774541
    .
  7. ISBN 978-0-8036-3827-3
    .
  8. ^ "Benzphetamine". Toxnet. Archived from the original on 2018-11-01.
  9. S2CID 20012024
    .

External links
Retrieved from "https://en.wikipedia.org/w/index.php?title=Benzphetamine&oldid=1188545396"