Bepridil

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Bepridil
Clinical data
Trade namesVascor
AHFS/Drugs.comMonograph
MedlinePlusa699051
Routes of
administration		Oral
ATC code
Pharmacokinetic data
BioavailabilityWell absorbed
Protein binding99%
MetabolismHepatic, CYP3A4-mediated
Elimination half-life42 hours
ExcretionRenal
Identifiers
  • N-benzyl-N-(3-isobutoxy-2-pyrrolidin-1-yl-propyl)aniline
JSmol)
  • O(CC(C)C)CC(N1CCCC1)CN(c2ccccc2)Cc3ccccc3
  • InChI=1S/C24H34N2O/c1-21(2)19-27-20-24(25-15-9-10-16-25)18-26(23-13-7-4-8-14-23)17-22-11-5-3-6-12-22/h3-8,11-14,21,24H,9-10,15-20H2,1-2H3 checkY
  • Key:UIEATEWHFDRYRU-UHFFFAOYSA-N checkY
  (verify)

Bepridil (trade name Vascor) is an

angina pectoris
. It is no longer sold in the United States.

It is nonselective.[1]

It has been discussed as a possible option in the treatment of atrial fibrillation.[2]

It has been implicated in causing ventricular arrhythmia (torsades de pointes).

Ebola research

In June 2015 a research paper [3] was published finding bepridil to result in a 100% survival rate for mice exposed to ebola during an experiment searching for potential pharmaceutical ebola treatments; indicating its potential use in future ebola research and therapy.[4]

SARS-CoV-2 research

A research paper [5] showed that Bepridil inhibited cytopathogenic effects induced by SARS-CoV-2 in Vero E6 cells and in A549 cells in an in vitro assay.

References

  1. PMID 7565636
    .
  2. PMID 18441448
    .
  3. PMID 26041706
    .
  4. ^ Cha AE (4 June 2015). "Zoloft as Ebola cure? Antidepressant is one of a number of promising drugs being looked at by scientists". Washington Post.
  5. PMID 33597253
    .

External links