Bernard Beryl Brodie
Bernard Beryl Brodie | |
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Hoffmann-LaRoche Pennsylvania State University |
Bernard Beryl Brodie (7 August 1907 – 28 February 1989) was a founding scientist in the area of biochemical and neurochemical
Career
Brodie was born in Liverpool, England on August 7, 1907, to a Jewish family, who emigrated to Ottawa, Canada in 1911. In 1926 he enlisted in the Royal Canadian Corps of Signals, where he learned boxing, winning a Canadian Army championship for his weight division.[1]
Brodie earned an undergraduate degree from McGill University, graduating in 1931. He received a Ph.D. in chemistry from New York University (NYU) in 1935. After graduation, he accepted a position in the Pharmacology Department at NYU, working with George B. Wallace. Brodie developed methods for measurement of drug metabolism, disposition, and response, which enabled him to generalize from experimental data to underlying principles and concepts. During World War II, Brodie played a key role at the Goldwater Research Service group at NYU, led by James A. Shannon.[1]
In 1950, Brodie was recruited by Shannon to join the
Research
During World War II, Brodie and others in the Goldwater Research Service group at NYU were tasked by
Together with Julius Axelrod, Brodie discovered how two popular headache remedies of the day were causing the illness methemoglobinemia, a non-lethal blood condition. They found that acetanilide is metabolized to aniline, and phenacetin to p-phenetidin. Brodie and Axelrod identified another metabolite, paracetamol, as beneficial, and suggested that manufacturers use it instead. It was later marketed as the analgesic Tylenol.[4][5]
Brodie also did research on anesthetic and hypnotic drugs. He correlated the distribution and clinical characteristics of
Brodie determined that specific drugs affected the
The biography, Apprentice to Genius by Robert Kanigel, describes Brodie's scientific career and the impact he had on a group of scientists who have gone on to make prize-winning breakthroughs in biomedical science.[9]
Awards
Brodie was elected to the National Academy of Sciences in 1966 and held memberships in the American Chemical Society, the American Heart Association, the International Union of Basic and Clinical Pharmacology and others.[3]
In 1967, Brodie received the
He has also received the Department of Health, Education and Welfare's Distinguished Service Award (1958),[10] the
He was the author or co-author of more than 350 scientific publications.[2][10]
The Bernard B. Brodie Award in Drug Metabolism and Disposition was first given in his honor in 1978 by the American Society for Pharmacology and Experimental Therapeutics.[13] The neuroscience department of the University of Cagliari was named in his honour by a former student, Gian Luigi Gessa.[14]
Brodie died in 1989 in Charlottesville, Virginia at the age of 81.[2][15]
Family
Bernard Brodie was a brother of polio researcher Maurice Brodie.[16]
References
- ^ PMID 2658766. Retrieved 14 March 2023.
- ^ a b c d Narvaez, Alfonso A. (2 March 1989). "Bernard B. Brodie, 81, a Pioneer In Drug Therapy Research, Dies". The New York Times. pp. B16. Retrieved 8 February 2010.
- ^ a b c "Bernard B. Brodie". National Academy of Sciences. Retrieved 14 March 2023.
- ^ "Work on the Sympathomimetic Amines, 1946-1958". Julius Axelrod - Profiles in Science. 12 March 2019. Retrieved 14 March 2023.
- S2CID 4413335.
- ^ Kanigel, Robert (14 March 1989). "One Scientist's Creative Way". Washington Post. Retrieved 14 March 2023.
- ^ "Bernard Beryl Brodie". Oxford Reference. Retrieved 14 March 2023.
- ^ a b c Hofschneider, Mark. "Physiological effects of drugs". Lasker Foundation. Retrieved 14 March 2023.
- ^ "Apprentice to Genius: The Making of a Scientific Dynasty by Robert Kanigel ‧ Release Date: Oct. 8, 1986". Kirkus Reviews. 15 September 1986. Retrieved 14 March 2023.
- ^ a b Whitaker, Joseph D. (2 March 1989). "RESEARCH SCIENTIST BERNARD BERYL (STEVE) BRODIE, 79, DIES". Washington Post. Retrieved 14 March 2023.
- ISSN 0009-2347.
- ^ "Dr. Bernard B. Brodie Receives Four Honors For Studies on Drugs" (PDF). The NIH Record. Vol. XXII, no. 14. 8 July 1970. Retrieved 14 March 2023.
- ^ "Bernard B. Brodie Award in Drug Metabolism and Disposition". American Society for Pharmacology and Experimental Therapeutics (ASPET). Retrieved 15 March 2023.
- ^ "Meet the Experts: Interview with Miriam Melis | Fundación CANNA: Scientific studies and cannabis testing". www.fundacion-canna.es. Retrieved 14 March 2023.
- .
- ^ "Dr. Bernard Brodie honored in US". Ottawa Journal. 3 April 1940.