Bert Vogelstein
Bert Vogelstein | |
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Joshua T. Vogelstein, and one more, Grandchildren: 5 | |
Awards | Breakthrough Prize in Life Sciences (2013)[1] Warren Triennial Prize (2014)[2] |
Scientific career | |
Fields | Oncology, Pathology |
Institutions | Johns Hopkins School of Medicine |
Doctoral students |
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Website | www |
Bert Vogelstein (born 1949) is director of the Ludwig Center, Clayton Professor of Oncology and Pathology and a
Research
In the 1980s, Vogelstein developed new experimental approaches to study human tumors.[5] His studies of various stages of colorectal cancers led him to propose a specific model for human tumorigenesis in 1988. In particular, he suggested that "cancer is caused by sequential mutations of specific oncogenes and tumor suppressor genes".[6][7][8]
The first tumor suppressor gene validating this hypothesis was that encoding
In 1991, Vogelstein and long-time colleague
Vogelstein and Kinzler worked with
In the early 2000s, Vogelstein and Kinzler, working with
Vogelstein pioneered the idea that somatic mutations represent uniquely specific biomarkers for cancer, creating the field now called "liquid biopsies". Working with post-doctoral fellow David Sidransky in the early 1990s, he showed that such somatic mutations were detectable in the stool of colorectal cancer patients and the urine of bladder cancer patients.[37][38] For this purpose, they developed "Digital PCR" in which DNA molecules are examined one-by-one to determine whether they are normal or mutated.[39] One of the techniques they invented for Digital PCR is called "BEAMing", in which the PCR is carried out on magnetic beads in water-in-oil emulsions.[40] BEAMing is now one of the core technologies used in some next-generation, massively parallel sequencing instruments. More recently, they developed a digital-PCR based technique called SafeSeqS, in which every DNA template molecule is recognized by a unique molecular barcode. SafeSeqS dramatically enhances the ability to identify rare variants among DNA sequences, allowing such variants to be detected when they are present in only 1 in more than 10,000 total DNA molecules.[41][42][43][44][45]
In mid-2019, Vogelstein started collaborating with the group of Martin Nowak at Harvard University. Together with their groups, they developed mathematical models to explain the evolution of resistance against targeted therapies.[46] They showed that the sequential administration of multiple targeted drugs precludes any chance for cure — even when there are no possible mutations that can confer cross-resistance to both drugs. Thus, simultaneous combination of targeted therapies (as opposed to sequential) is the preferred strategy as there is at least a potential for cure.[47]
Citations
Vogelstein has published nearly 600 scientific papers. Vogelstein's research papers have been cited over 430,000 times.[48]
In 2016 Semantic Scholar AI program included Vogelstein on its list of top ten most influential biomedical researchers.[49]
Awards
- 1990 – The Bristol Myers Squibb Award for "Distinguished Achievement in Cancer Research" [50]
- 1992 – The Young Investigator Award from the American Federation for Clinical Research, now the American Federation for Medical Research
- 1992 – The Gairdner Foundation International Award in Science [51]
- 1992 – The American Cancer Society Medal of Honor
- 1993 – The Hebrew University[52]
- 1993 – The Pezcoller Foundation Award from the American Association for Cancer Research[53]
- 1993 – The Richard Lounsbery Award from the National Academy of Sciences[54]
- 1993 – The Baxter Award from the Association of American Medical Colleges[55]
- 1994 – The Dickson Prize from the University of Pittsburgh
- 1994 – The Ernst Schering Prize[56]
- 1994 – The Passano Award from the Passano Foundation[57]
- 1994 – The Howard Taylor Ricketts Award from the University of Chicago[58]
- 1995 – The David A. Karnofsky Memorial Award from the American Society of Clinical Oncology[59]
- 1995 – The Clowes Memorial Award from the American Association for Cancer Research[60]
- 1997 – The William Beaumont Prize in Gastroenterology from the American Gastroenterological Association[61]
- 1997 – Golden Plate Award of the American Academy of Achievement[62]
- 1998 – The Louisa Gross Horwitz Prize[63]
- 1998 – The Paul Ehrlich and Ludwig Darmstaedter Prize from the Paul Ehrlich Foundation[64]
- 1998 – The William Allan Award from the American Society of Human Genetics[65]
- 2000 – The Charles S. Mott Prize from the General Motors Cancer Research Foundation
- 2001 – The Harvey Prize in Human Health from the Technion[66]
- 2001 – The Association for Molecular Pathology Award for Excellence in Molecular Diagnostics[67]
- 2003 – The John Scott Award from the John Scott Trust [68]
- 2004 – The Prince of Asturias Awards in Science [69]
- 2007 – The Pasarow Awardfor Medical Research
- 2011 – The Charles Rodolphe Brupbacher Prize for Cancer Research [70]
- 2012 – The New York Academy of Medicine Medal for Distinguished Contributions to Biomedical Science
- 2012 – The Pioneer in Science Award from the American Research Forum
- 2013 – Breakthrough Prize in Life Sciences[71]
- 2014 – Warren Triennial Prize [2][72]
- 2015 – Dr. Paul Janssen Award for Biomedical Research[73]
- 2018 – The Dan David Prize for Personalized Medicine [74][75]
- 2019 – Gruber Prize in Genetics[76]
- 2019 – Albany Medical Center Prize[77]
- 2020 – The Times 'Science Power List' [78]
- 2021 – Japan Prize[79]
Affiliations
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References
- ^ "Breakthrough Prize – Life Sciences Breakthrough Prize Laureates – Bert Vogelstein". breakthroughprize.org.
- ^ a b "Mass. General Hospital's Warren Triennial Prize to honor Bert Vogelstein, MD - Massachusetts General Hospital, Boston, MA". Archived from the original on 2015-02-21. Retrieved 2015-02-21.
- PMID 25550474– via clinchem.aaccjnls.org.
- ^ "Interview with Bert Vogelstein". Archived from the original on 2013-06-03. Retrieved 2010-04-30.
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- ^ "1360 Highly Cited Researchers (h>100) according to their Google Scholar Citations public profiles". Retrieved 1 February 2017.
- ^ "Who's the most influential biomedical scientist? Computer program guided by artificial intelligence says it knows". Science | AAAS. 17 October 2017. Retrieved 16 June 2021.
- ^ "Bristol Myers Squibb Award" (PDF). Archived from the original (PDF) on 2012-11-14. Retrieved 2015-04-02.
- ^ "Past Recipients / Bert Vogelstein". Canada Gairdner Award web site.
- ^ "Team BCPS: creating a culture of deliberate excellence, Baltimore County Public Schools". Archived from the original on 2017-09-20. Retrieved 2015-04-02.
- ^ "Nominations Open for 2010 Pezcoller Foundation–AACR International Award for Cancer Research". www.newswise.com.
- ^ "Richard Lounsbery Award". National Academy of Sciences. Retrieved 17 October 2022.
- ^ Baxter Award
- ^ "Bert Vogelstein Ernst Schering Prize 1994". Schering Stiftung. Retrieved 17 October 2022.
- ^ "Passano Award". Archived from the original on 2016-02-09. Retrieved 2015-04-02.
- ^ "Howard T. Ricketts Prize and Lecture -". biologicalsciences.uchicago.edu. University of Chicago. Retrieved 17 October 2022.
- ^ David A. Karnofsky Memorial Award
- ^ "AACR-G.H.A. Clowes Award for Outstanding Basic Cancer Research: Past Recipients".
- ^ William Beaumont Prize
- American Academy of Achievement.
- ^ "Horwitz Prize Awardees". cuimc.columbia.ed. Columbia University. 20 June 2018. Retrieved 17 October 2022.
- ^ "Prize Winners of the Paul Ehrlich and Ludwig Darmstaedter Prize" (PDF). The Paul Ehrlich Foundation. Retrieved 17 October 2022.
- ^ "Past Award Recipients - William Allan Award". ASHG. American Society of Human Genetics. Retrieved 17 October 2022.
- ^ "Harvey Prize". Technion Web Development Group. Retrieved 17 October 2022.
- ^ "Association for Molecular Pathology Award Honors".
- ^ "John Scott Award recipients". Archived from the original on 2010-07-01.
- ^ "Prince of Asturias Award for Technical & Scientific Research 2004".
- ^ "Cancer Research Prize". Charles Rodolphe Brupbacher Foundation. Archived from the original on 2015-04-03.
- ^ "Breakthrough Prize – Life Sciences Breakthrough Prize Laureates – Bert Vogelstein". BreakThroughPrize. Retrieved 17 October 2022.
- ^ Warren Triennial Prize
- ^ "Bert Vogelstein, M.D., Wins 2015 Dr. Paul Janssen Award". UAB "JOHNSON & JOHNSON". 17 June 2015. Retrieved 17 October 2022.
- ^ "US researchers receive Dan David Prize for outstanding cancer research". The Jerusalem Post | JPost.com. 8 February 2018. Retrieved 2020-04-21.
- ^ "May 2018: Dan David Prize laureates in Personalized Medicine". physics.tau.ac.il. Retrieved 2020-04-21.
- ^ "2019 Gruber Genetics Prize". The Gruber Foundation. Retrieved 17 October 2022.
- ^ "Albany Medical Center Announces Winners Of Prize In Medicine". WAMC Northeast Public Radio. 24 September 2019. Retrieved 17 October 2022.
- ISSN 0140-0460. Retrieved 2020-05-26.
- ^ "The Japan Prize Foundation". www.japanprize.jp.
- ^ "APS Member History". search.amphilsoc.org. Retrieved 2021-12-16.