Bi-specific T-cell engager
Bi-specific T-cell engagers (BiTEs) are a class of artificial
BiTEs are
Mechanism of action
Like other bispecific antibodies, and unlike ordinary monoclonal antibodies, BiTEs form a link between T cells and tumor cells. This causes T cells to exert
This action mimics physiological processes observed during T cell attacks against tumor cells.[4]
BiTEs in clinical assessment or with clinical approvals
Several BiTEs are currently in preclinical and clinical trials to assess their therapeutic efficacy and safety. [5]
Blinatumomab
Blinatumomab links T cells with CD19 receptors found on the surface of B cells. The Food and Drug Administration (US) and the European Medicines Agency approved this therapy for adults with Philadelphia chromosome-negative relapsed or refractory acute lymphoblastic leukemia.[6]
Glofitamab
It is a bispecific CD20-directed CD3 T-cell engager. It was approved for medical use in Canada in March 2023, in the United States in June 2023, and in the European Union in July 2023.
Mosunetuzumab
Bispecifically binds CD20 and CD3 to engage T-cells. Mosunetuzumab was approved for medical use in the European Union in June 2022.
Solitomab
Solitomab links T cells with the
Talquetamab
Tarlatamab
Tarlatamab has shown promise for previously treated small cell lung cancer.[9]
Tebentafusp
After clinical trials, in January 2022, the
Further research
Utilizing the same technology,
Another avenue for novel anti-cancer therapies is re-engineering some of the currently used conventional antibodies like
As of 2009[update], BiTEs against
References
- ^ "US Trademark registration no. 3,068,856, serial number 78/040,636". US Patent and Trademark Office.
- ^ a b Helwick, Caroline (1 June 2008). "Novel BiTE antibody mediates contact between T cells and cancer cells". Oncology NEWS International. 17 (6).
- ^ Rüttinger, D.; Zugmaier, G.; Nagorsen, D.; Reinhardt, C.; Baeuerle, P. A. (2008). "BiTE-Antikörper: Durch Bispezifität T-Lymphozyten gegen Tumorzellen richten" [BiTE antibodies: Directing T lymphocytes against tumor cells by bispecifity]. Journal Onkologie (in German) (4).
- ^ a b "BiTE Antibody Platform". Micromet Inc.
- S2CID 227100306.
- S2CID 214779717.
- S2CID 25568468.
- PMID 30221040.
- ISSN 0028-4793.
- ^ Research, Center for Drug Evaluation and (January 26, 2022). "FDA approves tebentafusp-tebn for unresectable or metastatic uveal melanoma". FDA.
- ^ a b Kischel, R; et al. (2008). "Characterization in primates of MCSP- and CD33-specific human BiTE antibodies for treatment of Melanoma and AML" (PDF). Proc Am Assoc Cancer Res. 99. Abs 2404. Archived from the original (PDF) on 2011-07-19.
- ^ Lutterbuese, R; et al. (2008). "Conversion of cetuximab, panitumumab, trastuzumab and omalizumab into T-cell-engaging BiTE antibodies creates novel drug candidates of high potency" (PDF). Proc Am Assoc Cancer Res. 99. Abs 2402. Archived from the original (PDF) on 2011-07-19.
- PMID 19509221.
Further reading
- Kufer, P; Lutterbüse, R; Baeuerle, PA (2004). "A revival of bispecific antibodies". Trends in Biotechnology. 22 (5): 238–44. PMID 15109810.