Bickerstaff brainstem encephalitis

Source: Wikipedia, the free encyclopedia.
Bickerstaff brainstem encephalitis
Other namesBBE, Bickerstaff’s encephalitis; Bickerstaff’s syndrome.
Miller-Fisher syndrome.[2]
TreatmentImmunotherapy.[2]

Bickerstaff brainstem encephalitis is a rare

Miller Fisher syndrome and Guillain–Barré syndrome.[2]

Signs and symptoms

The most frequent initial symptoms of Bickerstaff brainstem encephalitis are

Babinki’s sign, facial weakness, pupil abnormalities, bulbar palsy, and nystagmus are also commonly found. Symptoms tend to develop fairly quickly, within one to two days. There have been reports of dysesthesias and limb weakness as the presenting features of Bickerstaff brainstem encephalitis.[1]

Pathophysiology

The clinical features and course of the condition, the associated auto-antibodies against relevant

anti-ganglioside antibodies such as chronic ophthalmoplegia with anti-GQ1b antibody and the pharyngo-cervico-brachial variant of GBS.[6]

Diagnosis

Treatment

Most patients reported in the literature have been given treatments suitable for autoimmune neurological diseases, such as,

intravenous immunoglobulin, and most have made a good recovery.[7] The condition is too rare for controlled trials to have been undertaken.[9]

History

The first cases of bickerstaff brainstem encephalitis were reported in 1951 by Cloake and Bickerstaff under the name “Mesencephalitis and rhombencephalitis”.[4] Edwin Bickerstaff named the disease “brainstem encephalitis” in 1957.[10] The disorder has been known as Bickerstaff’s brainstem encephalitis ever since 1978 when Edwin Bickerstaff wrote a review in the Handbook of Clinical Neurology under the name “Brain stem encephalitis (Bickerstaff’s encephalitis)”.[11]

See also

References

External links