Biopterin-dependent aromatic amino acid hydroxylase

Source: Wikipedia, the free encyclopedia.
Biopterin_H
SCOP2
1toh / SCOPe / SUPFAM
CDDcd00361
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Biopterin-dependent aromatic amino acid hydroxylases (AAAH) are a family of aromatic

L-tryptophan
, respectively.

The AAAH enzymes are functionally and structurally related

substrate. The AAAH enzymes are regulated by phosphorylation at serines
in their N-termini.

Role in metabolism

In humans,

.

Structure

It has been suggested that the AAAH enzymes each contain a

regulatory (R) domain. It is possible that the R protein domains arose from genes that were recruited from different sources to combine with the common gene
for the catalytic core. Thus, by combining with the same C domain, the proteins acquired the unique regulatory properties of the separate R domains.

References