Biopterin-dependent aromatic amino acid hydroxylase
Biopterin_H | |||||||||
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CDD | cd00361 | ||||||||
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Biopterin-dependent aromatic amino acid hydroxylases (AAAH) are a family of aromatic
L-tryptophan
, respectively.
The AAAH enzymes are functionally and structurally related
substrate. The AAAH enzymes are regulated by phosphorylation at serines
in their N-termini.
Role in metabolism
In humans,
L-tryptophan to 5-hydroxy-L-tryptophan
.
Structure
It has been suggested that the AAAH enzymes each contain a
regulatory (R) domain. It is possible that the R protein domains arose from genes that were recruited from different sources to combine with the common gene
for the catalytic core. Thus, by combining with the same C domain, the proteins acquired the unique regulatory properties of the separate R domains.