Blue mass
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Blue mass (also known as blue pill or pilula hydrargyri) was the name of a mercury-based medicine common from the 17th to the 19th centuries. The oldest formula is ascribed to one Barbarossa, in a letter to Francis I of France.[1]
Description
Blue mass was used as a specific treatment for
The Edinburgh New Dispensatory (1789) instructs the making as follows: "Pilula ex Hydrargyro [London] (Quicksilver-pills). Take of Purified quicksilver, Extract of liquorice, having the consistence of honey, of each two drams, Liquorice, finally powdered, one dram. Rub the quicksilver with the extract of liquorice until the globules disappear; then, add the liquorice-powder, mix them together."[3]
A combination of blue mass and a mixture called the common
It was a
(used as a buffer) in some formulations.The ingredients of blue mass varied, as each pharmacist prepared it himself, but they all included mercury in elemental or compound form (often as mercury chloride, also known as calomel). One recipe of the period for blue mass syrup included:[4]
- 33% mercury (measured by weight)
- 5% licorice
- 25% hollyhock or marshmallow)
- 3% glycerol
- 34% rose honey
Blue pills were produced by substituting
(64.8 milligrams) of mercury.Toxicity
Mercury is now known to be toxic, and ingestion of mercury leads to
Use by Abraham Lincoln
For several years before his election to the presidency, Abraham Lincoln is known to have taken blue-mass pills for treatment of chronic melancholia.[5] It's been reported that during this time, Lincoln was known to have experienced neurological symptoms, including insomnia, tremor and rage attacks, which suggests he may have been suffering from mercury poisoning. However, a few months after his inauguration, Lincoln reportedly stopped taking the medication because he perceived the pills made him "cross".[5]
In 2001, a study led by renowned public-health investigator
References
- ^ Frazer, William. Elements of Materia Medica. Dublin, 1851, p. 173.
- ^ Marten, John. A Treatise of the Venereal Disease. London, 1711, p. 630.
- ^ The Edinburgh New Dispensatory (1789) p.573. London. 1789. p. 573.
- ^ King's American Dispensatory, 1898.
- ^ a b c "Lincoln's Little Blue Pills" (Press release). ScienceDaily: University Of Chicago Medical Center. 19 July 2001. Retrieved 2021-09-10.
- S2CID 37918186. Retrieved 2021-09-10.