Bolivian hemorrhagic fever

Source: Wikipedia, the free encyclopedia.
Machupo mammarenavirus
Virus classification Edit this classification
(unranked): Virus
Realm: Riboviria
Kingdom: Orthornavirae
Phylum:
Negarnaviricota
Class: Ellioviricetes
Order: Bunyavirales
Family: Arenaviridae
Genus: Mammarenavirus
Species:
Machupo mammarenavirus
Synonyms[1]

Machupo virus

Bolivian hemorrhagic fever
Infectious disease

Bolivian hemorrhagic fever (BHF), also known as black typhus or Ordog Fever, is a

infectious disease originating in Bolivia after infection by Machupo mammarenavirus.[2]

BHF was first identified in 1963 as an ambisense

Biosafety Level Four conditions, the highest level.[5]

During the period between February and March 2007, some 20 suspected BHF cases (3 fatal) were reported to the Servicio Departamental de Salud (SEDES) in

Iténez provinces.[7][8]

Epidemiology

History

The disease was first encountered in 1962, in the Bolivian village of San Joaquín, hence the name "Bolivian" Hemorrhagic Fever. When initial investigations failed to find an arthropod carrier, other sources were sought before finally determining that the disease was carried by infected mice. Although mosquitoes were not the cause as originally suspected, the extermination of mosquitoes using DDT to prevent malaria proved to be indirectly responsible for the outbreak in that the accumulation of DDT in various animals along the food chain led to a shortage of cats in the village; subsequently, a mouse plague erupted in the village, leading to an epidemic.[9]

Vectors

The

vector is the large vesper mouse (Calomys callosus), a rodent indigenous to northern Bolivia. Infected animals are asymptomatic and shed the virus in excreta, thereby infecting humans. Evidence of person-to-person transmission of BHF exists but is believed to be rare.[10]

Symptoms

The

hemorrhagic phase, usually within seven days of onset.[10] Severe hemorrhagic or neurologic symptoms are observed in about one third of patients. Neurologic symptoms involve tremors, delirium, and convulsions. The mortality rate is about 25%.[11]

Prevention

Measures to reduce contact between the vesper mouse and humans may have contributed to limiting the number of outbreaks, with no cases identified between 1973 and 1994. Although there are no cures or vaccine for the disease, a vaccine developed for the genetically related

prophylactic measure for people at high risk of infection. Post infection (and providing that the person survives the infection), those that have contracted BHF are usually immune to further infection of the disease.[10]

Weaponization

Bolivian hemorrhagic fever was one of three hemorrhagic fevers and one of more than a dozen agents that the United States researched as potential

biological weapons before the nation suspended its biological weapons program in 1969.[12] Albert Nickel, a 53-year old animal caretaker at Fort Detrick, died in 1964 from the disease after being bitten by an infected mouse. Nickel Place, on Fort Detrick, is named in his honor. It was also under research by the Soviet Union, under the Biopreparat bureau.[13]

Vaccine research

Investigational vaccines exist for Argentine hemorrhagic fever and RVF; however, neither is approved by FDA or commonly available in the United States.[14]

The structure of the attachment glycoprotein has been determined by X-ray crystallography and this glycoprotein is likely to be an essential component of any successful vaccine.[15]

References

  1. ^ "ICTV Taxonomy history: Machupo mammarenavirus". International Committee on Taxonomy of Viruses (ICTV). Retrieved 28 January 2019.
  2. ^ Public Health Agency of Canada: Machupo Virus Pathogen Safety Data Sheet, http://www.phac-aspc.gc.ca/lab-bio/res/psds-ftss/machupo-eng.php, Date Modified: 2011-02-18.
  3. ^ "Machupo". Retrieved 2009-01-22.
  4. PMID 4378149
    .
  5. ^ Center for Food Security & Public Health and Institute for International Cooperation in Animal Biologics, Iowa State University: Viral Hemorrhagic Fevers Caused by Arenaviruses, http://www.cfsph.iastate.edu/Factsheets/pdfs/viral_hemorrhagic_fever_arenavirus.pdf, last updated: February 23, 2010.
  6. ^ Aguilar PV, Carmago W, Vargas J, Guevara C, Roca Y, Felices V, et al. Reemergence of Bolivian hemorrhagic fever, 2007–2008 [letter]. Emerg Infect Dis [serial on the Internet] 2009 Sep. Available from http://wwwnc.cdc.gov/eid/article/15/9/09-0017.htm. Accessed 2 Dec 2011.
  7. ^ "Caso confirmado de fiebre hemorrágica alerta a autoridades benianas," Los Tiempos.com, "Caso confirmado de fiebre hemorrágica alerta a autoridades benianas". Archived from the original on 2012-03-15. Retrieved 2012-11-29., 16/11/2011.
  8. ^ "SEDES movilizado para controlar brote de fiebre hemorrágica en Beni; También se Capacita a Los Comunarios y Estudiantes," Lost Tiempos.com, "SEDES movilizado para controlar brote de fiebre hemorrágica en Beni". Archived from the original on 2011-12-01. Retrieved 2012-11-29., 30/11/2011.
  9. ^ Medical Microbiology 2nd edition; Mims et al. Mosby publishing 1998, p 371
  10. ^ a b c Kilgore, et al., (1995).
  11. PMID 24636947
    .
  12. ^ "Chemical and Biological Weapons: Possession and Programs Past and Present", James Martin Center for Nonproliferation Studies, Middlebury College, April 9, 2002, accessed November 14, 2008.
  13. ISBN 0-385-33496-6
    .
  14. ^ Shoemaker T, Choi M. "Travelers' Health: Viral Hemorrhagic Fevers". CDC. Retrieved 15 September 2020.
  15. PMID 19494008
    .

Bibliography

  • Medical Microbiology 2nd Edition Mims et al. Mosby Publishing 1998 p 371

External links

Retrieved from "https://en.wikipedia.org/w/index.php?title=Bolivian_hemorrhagic_fever&oldid=1176289874"