Bourbon virus
Bourbon virus | |
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Electron micrograph of the spherical form of Bourbon virus (scale bar: 100 nm) | |
Virus classification | |
(unranked): | Virus |
Realm: | Riboviria |
Kingdom: | Orthornavirae |
Phylum: | Negarnaviricota
|
Class: | Insthoviricetes |
Order: | Articulavirales |
Family: | Orthomyxoviridae |
Genus: | Thogotovirus |
Virus: | Bourbon virus
|
Bourbon virus is an
Discovery
The virus was discovered in 2014 by Olga Kosoy, Amy Lambert and colleagues from the
Next,
Virology
Bourbon virus is a type of
Epidemiology
The Bourbon virus was first identified in a previously healthy man aged more than 50 years from
The case patient reported multiple tick bites, including a blood-filled tick in the shoulder area that was observed a few days before the onset of symptoms.[2] Based on the history of the case patient, the virus is considered to be possibly tick-borne, but this has not been proven. Most thogotoviruses are transmitted solely by ticks, but the similar Batken virus has also been isolated from mosquitoes.[2][10] Studies to establish the prevalence of Bourbon virus in tick and insect populations were planned in December 2014.[5][7]
Signs and symptoms
The patient had high
The degree, if any, to which the Bourbon virus contributed to the individual's illness and death remains unknown as of February 2015, as does whether these symptoms and laboratory abnormalities represent the typical course of infection with Bourbon virus.[2][5] Hawkinson has speculated that there have been previous undiagnosed cases with milder symptoms from which the infected patients recovered.[7]
Thogotoviruses rarely cause disease in humans. The case in Bourbon County is only the eighth report of human disease associated with a thogotovirus globally.
Treatment and prevention
No routine diagnostic test is yet available.[6] There is currently no specific treatment or vaccine for the virus;[5][6] supportive therapy is recommended.[6] On the assumption that the virus is transmitted by a tick or insect, the main prevention method recommended is the avoidance of tick and insect bites.[6] In mice models, Favipiravir has been shown to be beneficial both therapeutically and prophylactically.[15]
See also
References
- ^ Bernhard, Blyth, "Meramec State Park employee dies after catching mysterious tick illness", "St. Louis Post-Dispatch, 12 July 2017
- ^ PMID 25899080.
- ^ a b c "Tried-and-true and state-of-the-art combine to uncover a hidden virus", CDC website, CDC, retrieved 4 March 2015
- ^ a b c "New "Bourbon Virus" linked to death", Medical News Network: the University of Kansas Hospital, University of Kansas, retrieved 24 December 2014
- ^ a b c d e f g h i KDHE Office of Communications (22 December 2014), KDHE and CDC Investigate New Virus, KDHE Office of Communications, archived from the original on 31 December 2014, retrieved 30 December 2014
- ^ a b c d e f g h i "Bourbon virus", CDC website, Division of Vector-Borne Diseases, CDC, retrieved 4 March 2015
- ^ a b c d Grady, Denise (23 December 2014), "Mysterious virus that killed a farmer in Kansas Is Identified", The New York Times, retrieved 5 March 2015
- ^ "Missouri woman dies of rare tick-borne illness called 'Bourbon virus'". USA TODAY. Retrieved 2017-07-13.
- ^ "Woman dies after contracting rare tick-borne "Bourbon virus"". CBS News. Retrieved 2017-07-13.
- PMID 9349464.
- PMID 21994326
- PMID 3445590.
- PMID 24574415.
- ^ Lowes, Robert (December 24, 2014). "Discovery of Bourbon Virus Raises Many Questions". Medscape Medical News. Medscape. Archived from the original on 2015-01-12. Retrieved December 18, 2017.
- PMID 31194854.