Breast milk

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Breastmilk
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"Mother's milk" redirects here. For other uses, see Mother's Milk (disambiguation).
Two samples of human breast milk. The sample on the left is the first milk produced by the mother, while the sample on the right was produced later during the same breast pumping cycle.

Breast milk (sometimes spelled as breastmilk) or mother's milk is

gut microbiome.[1]

Use and methods of consumption

Pumped breast milk in bottles
Breast feeding latch

The

formula milk.[2]

Breast milk constitutes the sole source of nutrition for exclusively breastfed newborns, supplying all necessary nutrients for infants up to six months. Beyond this age, breast milk continues to be a source of energy for children up to two years old, providing over half of a child's energy needs up to the age of one and a third of the needs between one and two years of age.[2]

Despite the capability of most newborns to latch onto the mother's breast within an hour of birth, globally, sixty percent of infants are not breastfed within this crucial first hour. Breastfeeding within the first hour of life protects the newborn from acquiring infections and reduces risk of death during the neonatal period.[3][4]

Alternatively, breast milk can be expressed using a

preterm babies who may initially lack the ability to suck effectively. Using cups to feed expressed breast milk and other supplements results in improved breastfeeding outcomes in terms of both duration and extent, compared with traditional bottle and tube feeding.[5][6]

For mothers unable to produce an adequate supply of breast milk, the use of

pasteurized donor human breast milk is a viable option. In the absence of pasteurized donor milk, commercial formula milk is recommended as a secondary alternative.[7] However, unpasteurized breast milk from a source other than the infant's mother, particularly when shared informally, carries the risk of vertically transmitting bacteria, viruses (such as HIV), and other microorganisms from the donor to the infant, rendering it an unsafe alternative.[7][8]

Benefits

Breastfeeding offers health benefits to mother and child even after infancy.

psychological disorders, including in adopted children.[19] In addition, feeding an infant breast milk is associated with lower insulin levels and higher leptin levels compared feeding an infant via powdered-formula.[20] Many of the infection-fighting and immune system related benefits are associated with human milk oligosaccharides.[21]

Breastfeeding also provides health benefits for the mother. It assists the uterus in returning to its pre-pregnancy size and reduces post-partum bleeding, through the production of oxytocin (see Production). Breastfeeding can also reduce the risk of breast cancer later in life.[22][23] Lactation may also reduce the risk for both mother and infant from both types of diabetes.[24] Lactation may protect the infant from specifically developing Type 2 diabetes, as studies have shown that bioactive ingredients in human breast milk could prevent excess weight gain during childhood via contributing to a feeling of energy and satiety. A lower risk of child-onset diabetes may be more applicable to infants who were born from diabetic mothers.[20] The reason is that while breastfeeding for at least the first six months of life minimizes the risk of type 1 diabetes from occurring in the infant, inadequate breastfeeding in an infant prenatally exposed to diabetes was associated with a higher risk of the child developing diabetes later.[20] However, it can be argued that human breastfeeding may contribute to protective effects against the development of type 1 diabetes because the alternative of bottle-feeding may expose infants to unhygienic feeding conditions.[25]

Though it now is almost universally prescribed, in some countries, in the 1950s the practice of

hormones.[27] Breast milk also contains antibodies and lymphocytes from the mother that help the baby resist infections.[28] The immune function of breast milk is individualized, as the mother, through her touching and taking care of the baby, comes into contact with pathogens that colonize the baby, and, as a consequence, her body makes the appropriate antibodies and immune cells.[29]

At around four months of age, the internal iron supplies of the infant, held in the hepatic cells of the liver, are exhausted. The American Academy of Pediatrics recommends that at this time that an iron supplement should be introduced.[30] Other health organisations such as the NHS in the UK have no such recommendation.[31] Breast milk contains less iron than formula, but the iron is more bioavailable as lactoferrin, which carries more safety for mothers and children than ferrous sulphate.[32]

Both the AAP[33] and the NHS recommend vitamin D supplementation for breastfed infants.[31] Vitamin D can be synthesised by the infant via exposure to sunlight; however, many infants are deficient due to being kept indoors or living in areas with insufficient sunlight. Formula is supplemented with vitamin D for this reason.[31][33]

Production

See also: Low milk supply

Under the influence of the hormones

IgA, which coats the gastrointestinal tract. This helps to protect the newborn until its own immune system is functioning properly. It also creates a mild laxative effect, expelling meconium and helping to prevent the build-up of bilirubin (a contributory factor in jaundice[35]). Male lactation can occur; the production or administration of the hormone prolactin is necessary to induce lactation (see male lactation
).

Actual inability to produce enough milk is rare, with studies showing that mothers from malnourished regions still produce amounts of milk of similar quality to that of mothers in developed countries.

hormonal contraceptives), illness, and dehydration. A rarer reason is Sheehan's syndrome, also known as postpartum hypopituitarism
, which is associated with prolactin deficiency and may require hormone replacement.

The amount of milk produced depends on how often the mother is nursing and/or

Cochrane review came to the conclusion that a greater volume of milk is expressed whilst listening to relaxing audio during breastfeeding, along with warming and massaging of the breast prior to and during feeding. A greater volume of milk expressed can also be attributed to instances where the mother starts pumping milk sooner, even if the infant is unable to breastfeed.[41]

low birthweight infants.[41] If pumping, it is helpful to have an electric, high-grade pump so that all of the milk ducts are stimulated. Galactagogues increase milk supply, although even herbal variants carry risks. Non-pharmaceutical methods should be tried first, such as pumping out the mother's breast milk supply often, warming or massaging the breast, as well as starting milk pumping earlier after the child is born if they cannot drink milk at the breast.[41][42][43][44]

The impact of stress on breast milk supply is a major concern for many mothers who are breastfeeding. Stress is a natural part of life, but its effect on milk production can be significant, leading to worry and frustration for new mothers. When stress occurs, the body releases cortisol, a hormone associated with the "fight-or-flight" response. While cortisol is important in emergency situations, consistently high levels of it can disrupt the delicate balance of prolactin and oxytocin, two hormones essential for milk production. Elevated cortisol levels can suppress prolactin production, reducing milk production. Moreover, stress can impede the oxytocin reflex, making it more difficult for milk to flow freely, further impacting milk supply.[45]

Composition

Further information: Anti inflammatory agents in breast milk, Human milk immunity, and Human milk microbiome
Human breast milk
Nutritional value per 100 mL
Energy65–78 kcal (270–330 kJ)
6.7–7.8 g
Sugars
6.7–7.8 g
3.2–4.8 g
0.8–1.4 g
Niacin (B3)
1%
0.15 mg
Vitamin B6
–%
9–21 μg
Folate (B9)
–%
2–5 μg
Vitamin B12
4%
0.1 μg
Vitamin C
4%
4 mg
Vitamin D
0%
2 IU
Vitamin E
1%
0.2 mg
Vitamin K
0%
0.2 μg
Copper
–%
0.00001–0.00003 mg
Iron
–%
0.03–0.07 mg
Magnesium
–%
3–3.5 mg
Manganese
–%
0.0003–0.0004 mg
Phosphorus
–%
12–14 mg
Potassium
–%
40–55 mg
Selenium
–%
1–2.5 μg
Sodium
–%
15–25 mg
Zinc
–%
0.0001–0.0003 mg
Other constituentsQuantity
Water87–88 g
†Percentages estimated using US recommendations for adults,[49] except for potassium, which is estimated based on expert recommendation from the National Academies.[50]
Source: [46][47][48]

Breast milk contains fats, proteins, carbohydrates (including lactose and human milk oligosaccharides), and a varying composition of minerals and vitamins.[51][52] The composition changes over a single feed as well as over the period of lactation.[53] Changes are particularly pronounced in marsupials.[54]

Colostrum vs breastmilk

During the first few days after delivery, the mother produces colostrum. This is a thin yellowish fluid that is the same fluid that sometimes leaks from the breasts during pregnancy. It is rich in protein and antibodies that provide passive immunity to the baby (the baby's immune system is not fully developed at birth). Colostrum also helps the newborn's digestive system to grow and function properly.[citation needed]

Colostrum will gradually change to become mature milk. In the first 3–4 days it will appear thin and watery and will taste very sweet; later, the milk will be thicker and creamier. Human milk quenches the baby's thirst and hunger and provides the proteins, sugar, minerals, and antibodies that the baby needs.

In the 1980s and 1990s, lactation professionals (De Cleats) used to make a differentiation between foremilk and hindmilk. But this differentiation causes confusion as there are not two types of milk. Instead, as a baby breastfeeds, the fat content very gradually increases, with the milk becoming fattier and fattier over time.[55]

The level of Immunoglobulin A (IgA) in breast milk remains high from day 10 until at least 7.5 months post-partum.[56]

Human milk contains 0.8–0.9% protein, 4.5% fat, 7.1% carbohydrates, and 0.2% ash (minerals).

triglycerides of palmitic and oleic acid (O-P-O triglycerides), and also lipids with trans bonds (see: trans fat). The lipids are vaccenic acid, and conjugated linoleic acid (CLA) accounting for up to 6% of the human milk fat.[59][60]

The principal proteins are alpha-

tumor cells.[citation needed] This is thought to contribute to the protection of breastfed babies against cancer.[61]

Non-protein nitrogen-containing compounds, making up 25% of the milk's nitrogen, include

circadian variations; some of the nucleotides are more commonly produced during the night, others during the day.[64]

Mother's milk has been shown to supply

N-arachidonoyl glycine,[68] eicosapentaenoyl ethanolamide,[68] docosahexaenoyl ethanolamide,[68] N-palmitoleoyl-ethanolamine,[68] dihomo-γ-linolenoylethanolamine,[68] N-stearoylethanolamine,[68] prostaglandin F2alpha ethanolamides[68] and prostaglandin F2 ethanolamides,[68] Palmitic acid esters of hydroxy-stearic acids (PAHSAs).[69] They may act as an appetite stimulant, but they also regulate appetite so infants do not eat too much. That may be why formula-fed babies have a higher caloric intake than breastfed babies.[70]

Breast milk is not sterile and has its own microbiome, but contains as many as 600 different species of various bacteria, including beneficial Bifidobacterium breve, B. adolescentis, B. longum, B. bifidum, and B. dentium, which contribute to colonization of the infant gut.[71] As a result, it can be defined as a probiotic food, depending on how one defines "probiotic".[72] Breast milk also contains a variety of somatic cells and stem cells and the proportion of each cell type differs from individual to individual.[73][74] The somatic cells are mainly lactocytes and myoepithelial cells derived from the mother's mammary glands.[75] The stem cells found in human breast milk have been shown to be able to differentiate into a variety of other cells involved in the production of bodily tissues and a small proportion of these cross over the nursing infant's intestinal tract into the bloodstream to reach certain organs and transform into fully functional cells.[76] Because of its diverse population of cells and multifarious functions, researchers have argued that breast milk should be considered a living tissue.[73]

Breast milk contains a unique type of sugars,

immune cell responses, which may benefit the infant. As of 2015 more than a hundred different HMOs have been identified; both the number and composition vary between women and each HMO may have a distinct functionality.[79]

The breast milk of diabetic mothers has been shown to have a different composition from that of non-diabetic mothers. It may contain elevated levels of glucose and insulin and decreased polyunsaturated fatty acids. A dose-dependent effect of diabetic breast milk on increasing language delays in infants has also been noted, although doctors recommend that diabetic mothers breastfeed despite this potential risk.[80]

Women

HTLV-1), or medications.[81] Even though most infants infected with HIV contract the disease from breastfeeding, most infants that are breastfed by their HIV positive mothers never contract the disease.[82] While this paradoxical phenomenon suggests that the risk of HIV transmission between an HIV positive mother and her child via breastfeeding is small, studies have also shown that feeding infants with breast milk of HIV-positive mothers can actually have a preventative effect against HIV transmission between the mother and child.[82] This inhibitory effect against the infant contracting HIV is likely due to unspecified factors exclusively present in breast milk of HIV-positive mothers.[82]

Most women that do not breastfeed use infant formula, but breast milk donated by volunteers to human milk banks can be obtained by prescription in some countries.[83] In addition, research has shown that women who rely on infant formula could minimize the gap between the level of immunity protection and cognitive abilities a breastfed child benefits from versus the degree to which a bottle-fed child benefits from them.[84] This can be done by supplementing formula-fed infants with bovine milk fat globule membranes (MFGM) meant to mimic the positive effects of the MFGMs which are present in human breast milk.[85]

Storage of expressed breast milk

Bottle of pumped breast milk

Expressed breast milk can be stored. Lipase may cause thawed milk to taste soapy or rancid due to milk fat breakdown. It is still safe to use, and most babies will drink it. Scalding it will prevent rancid taste at the expense of antibodies.[86] It should be stored with airtight seals. Some plastic bags are designed for storage periods of less than 72 hours. Others can be used for up to 12 months if frozen. This table describes safe storage time limits.[87]

Place of storage Temperature Maximum storage time
In a room 25 °C 77 °F Six to eight hours
Insulated thermal bag with ice packs Up to 24 hours
In a refrigerator 4 °C 39 °F Up to five days
Freezer compartment inside a refrigerator
 −15 °C 5 °F Two weeks
A combined refrigerator and freezer with separate doors −18 °C 0 °F Three to six months
Chest or upright manual defrost deep freezer −20 °C −4 °F Six to twelve months

Comparison to other milks

All mammalian species produce milk, but the composition of milk for each species varies widely and other kinds of milk are often very different from human breast milk. As a rule, the milk of mammals that nurse frequently (including human babies) is less rich, or more watery, than the milk of mammals whose young nurse less often. Human milk is noticeably thinner and sweeter than cow's milk.

Whole cow's milk contains too little

kidneys. In addition, the proteins, fats and calcium in whole cow's milk are more difficult for an infant to digest and absorb than the ones in breast milk.[89][92][93]

The composition of marsupial and monotreme milk contains essential nutrients, growth factors and immunological properties to support the development of joeys and puggles.[54]

Comparing milks (per cup in SI units of measurement)[94][permanent dead link][95]
Nutrient Human milk
Cow
milk (3.25% fat) 		Goat milk
Calories
(Kcal) 		172 146 168
Water (g) 215 215 212
Protein (g) 2.5 7.9 8.7
Fat (g) 10.8 7.9 10.1
Saturated fat (g) 4.9 4.6 6.5
Monounsaturated fat (g) 4.1 2.0 2.7
Polyunsaturated fat (g) 1.2 0.5 0.4
Omega-3 fatty acids (mg) 128 183 97.6
Omega-6 fatty acids (mg) 920 293 266
Cholesterol (mg) 34.4 24.4 26.8
Carbohydrate (g) 17.0 11.0 10.9
Sugars (g) 17.0 11.0 10.9
Vitamin A (IU) 522 249 483
Vitamin C (mg) 12.3 0 3.2
Vitamin D (IU) * 9.8 97.6 29.3
Vitamin E (mg) 0.2 0.1 0.2
Vitamin K (mcg) 0.7 0.5 0.7
Thiamin
(mg) 		0.0 0.1 0.1
Riboflavin (mg) 0.1 0.4 0.3
Niacin
(mg) 		0.4 0.3 0.7
Vitamin B6 (mg) 0.0 0.1 0.1
Folate (mcg) 12 12 2
Vitamin B12 (mcg) 0.1 1.1 0.2
Pantothenic acid (mg) 0.5 0.9 0.8
Choline (mg) 39.4 34.9 39.0
Calcium (mg) 79 276 327
Iron (mg) 0.07 0.07 0.12
Magnesium (mg) 7.4 24.4 34.2
Phosphorus (mg) 34.4 222 271
Potassium (mg) 125 349 498
Sodium (mg) 42 98 122
Zinc (mg) 0.4 1.0 0.7
Copper (mg) 0.1 0.0 0.1
Manganese (mg) 0.1 0.0 0.0
Selenium (mcg) 4.4 9.0 3.4

* Note: Milk is generally fortified with vitamin D in the U.S. and Canada. Non-fortified milk contains only 2 IU per 3.5 oz.

Effects of medications and other substances on milk content

Main article: Breastfeeding and medications
Further information: Breast milk-mediated drug delivery

Almost all medicines, or drugs, pass into breastmilk in small amounts by a

molecular weight, and highly lipid-soluble are more likely to enter the breast milk in larger quantities.[98] Some drugs have no effect on the baby and can be used whilst breastfeeding, while other medications may be dangerous and harmful to the infant.[99][98]

Some medications considered generally safe for use by a breastfeeding mother, with a doctor’s or pharmacist’s advice, include simple analgesics or pain killers such as

SNRI classes, and medications for gastroesophageal reflux such as omeprazole and ranitidine.[101]

Conversely, there are medications that are known to be toxic to the baby and thus should not be used in breastfeeding mothers, such as

immunosuppressants like methotrexate,[102] amiodarone, or lithium.[98][97]

Furthermore,

drugs of abuse, such as cocaine, amphetamines, heroin, and marijuana cause adverse effects on the infant during breastfeeding. Adverse effects include seizures, tremors, restlessness, and diarrhea.[102]

To reduce infant exposure to medications used by the mother, use topical therapy or avoid taking the medication during breastfeeding times when possible.[96]

Hormonal products and combined oral contraceptives should be avoided during the early postpartum period as they can interfere with lactation.[101]

There are some medications that may stimulate the production of breast milk. These medications may be beneficial in cases where women with hypothyroidism may be unable to produce milk.[103][104] A Cochrane review looked at the drug domperidone (10 mg three times per day) with results showing a significant increase in volume of milk produced over a period of one to two weeks.[105] However, another review concluded little evidence that use of domperidone and metoclopramide to enhance milk supply works. Instead, non-pharmacological approaches such as support and more frequent breastfeeding may be more efficacious.[97]

Finally, there are other substances besides medications that may appear in breast milk. Alcohol use during pregnancy carries a significant risk of serious birth defects, but consuming alcohol after the birth of the infant is considered safe.[106] High caffeine intake by breastfeeding mothers may cause their infants to become irritable or have trouble sleeping.[97] A meta-analysis has shown that breastfeeding mothers who smoke expose their infants to nicotine, which may cause respiratory illnesses, including otitis media in the nursing infant.[102]

Market

Main article: human milk bank

There is a commercial market for human breast milk, both in the form of a wet nurse service and as a milk product.

As a product, breast milk is exchanged by

aerobic bacteria.[107] Bacterial growth happens during transit.[107] According to the FDA, bad bacteria in food at room temperature can double every 20 minutes.[108]

Human milk is considered to be healthier than cow's milk and infant formula when it comes to feeding an infant in the first six months of life, but only under extreme situations do international health organizations support feeding an infant breast milk from a healthy wet nurse rather than that of its biological mother.[109] One reason is that the unregulated breast milk market is fraught with risks, such as drugs of abuse and prescription medications being present in donated breast milk.[109] The transmission of these substances through breast milk can do more harm than good when it comes to the health outcomes of the infant recipient.[109]

Fraud

In the United States, the online marketplace for breast milk is largely unregulated and the high premium has encouraged

cow’s milk, soy milk, and water and even soy milk undermining health benefits. [110][112]

Older consumption

A 2015

cow's milk." The article also explains that milk purchased online may be improperly sanitized or stored, so it may contain food-borne illness and infectious diseases such as hepatitis and HIV.[113]

Restaurants and recipes

A minority of people, including restaurateurs Hans Lochen of Switzerland and Daniel Angerer of Austria, who operates a restaurant in New York City, have used human breast milk, or at least advocated its use, as a substitute for cow's milk in dairy products and food recipes.[114][115] An Icecreamist in London's Covent Garden started selling an ice cream named Baby Gaga in February 2011. Each serving cost £14. All the milk was donated by a Mrs Hiley who earned £15 for every 10 ounces and called it a "great recession beater".[116] The ice cream sold out on its first day. Despite the success of the new flavour, the Westminster Council officers removed the product from the menu to make sure that it was, as they said, "fit for human consumption."[117] Tammy Frissell-Deppe, a family counsellor specialized in attachment parenting, published a book, titled A Breastfeeding Mother's Secret Recipes, providing a lengthy compilation of detailed food and beverage recipes containing human breast milk.[118] Human breast milk is not produced or distributed industrially or commercially, because the use of human breast milk as an adult food is considered unusual to the majority of cultures around the world, and most disapprove of such a practice.[119]

In Costa Rica, there have been trials to produce human cheese, and custard from human milk, as an alternative to weaning.[120]

Bodybuilders

While there is no scientific evidence that shows that breast milk is advantageous for adults, according to several 2015 news sources, breast milk is being used by

bodybuilders for its nutritional value. In a February 2015 ABC News article, one former competitive body builder said, "It isn't common, but I've known people who have done this. It's certainly talked about quite a bit on the bodybuilding forums on the Internet." Calling bodybuilders "a strange breed of individuals", he said, "Even if this type of thing is completely unsupported by research, they're prone to gym lore and willing to give it a shot if there is any potential effect." At the time the article was written, in the U.S., the price of breast milk procured from milk banks that pasteurize the milk, and have expensive quality and safety controls, was about $10 per US fluid ounce ($0.34/ml), and the price in the alternative market online, bought directly from mothers, ranges from $1–$4 per US fluid ounce ($0.03–$0.14/ml), compared to cow's milk at about $3.44 per US gallon ($0.0269/US fl oz; $0.0009/ml).[121][122]

Breast milk contamination

Breast milk is oftentimes used as an environmental bioindicator given its ability to accumulate certain chemicals, including organochlorine pesticides.

organochlorine pesticides, PCDDs, PBDEs, and DDT can contaminate breastmilk.[124] According to research done in 2002, the levels of the organochlorine pesticides, PCBs, and dioxins have declined in breast milk in countries where these chemicals have been banned or otherwise regulated, while levels of PBDEs are rising.[124]

Pesticide contamination in breastmilk

Pesticides and other toxic substances

persistent organic pollutants in the body; the breast milk of Inuit mothers is extraordinarily high in toxic compounds.[125]

The CDC has provided some resources for breastfeeding mothers to reference for safe medication use, including LactMed, Mother to Baby, and The InfantRisk Center.[126]

Contamination effects of organochlorine pesticides on infants

When a mother is exposed to organochlorine pesticides (OCP's), her infant can be exposed to these OCP's through breast milk intake. This result is supported by a study done in India, which revealed that in each lactation period there is a loss of OCPs from the mother's body involved in the nursing of their children. A longitudinal study was conducted to assess pesticide residues in human breast milk samples and evaluate the risk-exposure of infants to these pesticides from consumption of mother’s milk in Ethiopia. The estimated daily intake (EDI) of infants in the present study was above provisional tolerable daily intake (PTDI) during the first month of breastfeeding which indicates that there is a health risk for infants consuming breast milk at an early stage of breastfeeding in the study areas. Based on these studies, the exposure of women during pregnancy to these OCPs may lead to various health problems for fetus such as low birth weight, disturbance of thyroid hormone, and neurodevelopmental delay.[127]

See also

References

  1. ^ Association, Australian Breastfeeding (2017-07-03). "Breastmilk composition". Australian Breastfeeding Association. Retrieved 2021-01-29.
  2. ^ a b "Infant and young child feeding". www.who.int. Retrieved 2024-03-03.
  3. ^ "World Health Organization; Exclusive breastfeeding". Who.int. 2021. Retrieved 2021-12-01.
  4. PMID 22371471
    .
  5. ^
    PMID 34671969
    .
  6. PMID 19025602
    .
  7. ^
    PMID 33365109
    .
  8. ^ Society, Canadian Paediatric. "Pasteurized and unpasteurized donor human milk | Canadian Paediatric Society". cps.ca. Retrieved 2022-04-28.
  9. ^ "The World Health Organization's infant feeding recommendation". Archived from the original on January 8, 2012.
  10. PMID 31081799
    .
  11. S2CID 1257376
    .
  12. ^ "Breastfeeding Associated With Increased Intelligence, Study Suggests". Archived from the original on 2021-01-15. Retrieved 2018-02-28.
  13. PMID 6409579
    .
  14. S2CID 37717003
    .
  15. PMID 22863497
    .
  16. PMID 23304866
    .
  17. ^
    PMID 23372130
    .
  18. S2CID 25934526
    .
  19. PMID 16722597
    .
  20. ^
    PMID 21357361
    .
  21. PMID 22513036
    .
  22. ^ Gillego A, Bernik S. "Breast-Feeding Might Cut Risk for Tough-to-Treat Breast Cancer: Study". Archived from the original on 3 March 2016. Retrieved 18 October 2012.
  23. S2CID 219696836
    .
  24. PMID 21348815
    .
  25. S2CID 24794632
    .
  26. ^ "Breastfeeding". www.who.int. Retrieved 2022-04-28.
  27. ^
    PMID 21091243
    .
  28. PMID 2147370
    .
  29. ^ "The Newborn Immune System and Immunological Benefits of Breastmilk". Archived from the original on 2021-03-09. Retrieved 2013-02-23.
  30. ISSN 1073-0397. Archived from the original on 2015-12-18.{{cite journal}}: CS1 maint: DOI inactive as of January 2024 (link
    )
  31. ^ a b c "First Foods". Start 4 Life. National Health Service. Retrieved 2018-11-21.
  32. S2CID 14807311
    .
  33. ^
    ISSN 0002-838X
    .
  34. ^ "Lactation (Human Milk Production): Causes & How It Works". Cleveland Clinic. Retrieved 2022-04-28.
  35. PMID 23422701.{{cite journal}}: CS1 maint: DOI inactive as of April 2024 (link
    )
  36. ^ Prentice, A.M., Paul, A., Prentice, A., Black, A., Cole, T., & Whitehead, R. (1986). Cross – cultural differences in lactational performance. In Maternal Environmental Factors in Human Lactation. Human Lactation 2, pp. 13 = 44 [Hamosh, M., & Goldman, A.S. (eds)]. New York: Plenum Press.
  37. ^ "Low milk supply: What causes it?". Mayo Clinic. Retrieved 2022-04-28.
  38. ^ "Breast-feeding: Pumping and maintaining your milk supply". MayoClinic.com. 2010-03-13. Retrieved 2011-10-26.
  39. ^ "Breast milk: Increasing supply – iVillage". Parenting.ivillage.com. 2010-01-01. Archived from the original on 2010-05-14. Retrieved 2011-10-26.
  40. ^ "How Breast Milk is Produced". Babies.sutterhealth.org. Retrieved 2011-10-26.
  41. ^
    PMID 25722103
    .
  42. ^ "Fenugreek Seed for Increasing Supply".
  43. ^ "Increasing Low Milk Supply".
  44. PMID 29757199
    .
  45. ^ Lindley (2024-02-06). "Does Stress Affect Milk Supply? Know The Impact and Practical Solutions". Retrieved 2024-03-01.
  46. PMID 23178060
    .
  47. PMID 32252145
    .
  48. PMID 11339161
    .
  49. ^ United States Food and Drug Administration (2024). "Daily Value on the Nutrition and Supplement Facts Labels". Retrieved 2024-03-28.
  50. PMID 30844154.{{cite book}}: CS1 maint: multiple names: authors list (link
    )
  51. PMID 32252145
    .
  52. ISBN 9780429080340
    , retrieved 2022-04-28
  53. PMID 26375355
    .
  54. ^
    PMID 32612884
    .
  55. ^ Mohrbacher, Nancy (2011-07-10). "Worries About Foremilk and Hindmilk". Breastfeeding USA. Archived from the original on 2021-01-15. Retrieved 1 March 2015.
  56. doi:10.1016/s1201-9712(02)90302-4
    .
  57. ISBN 978-3-540-69935-4
    .
  58. PMID 34572236
    .
  59. PMID 10481820
    .
  60. PMID 16988126
    .
  61. PMID 12665051
    .
  62. PMID 392766
    .
  63. S2CID 36817657
    .
  64. S2CID 30414322. Archived from the original
    on 2009-08-12.
  65. ^ Fride E, Bregman T, Kirkham TC (April 2005). "Endocannabinoids and food intake: newborn suckling and appetite regulation in adulthood" (PDF). Experimental Biology and Medicine. 230 (4): 225–34.
    S2CID 25430588
    .
  66. ^ The Endocannabinoid-CB Receptor System: Importance for development and in pediatric disease Archived 2016-04-02 at the Wayback Machine Neuroendocrinology Letters Nos.1/2, Feb–Apr Vol.25, 2004.
  67. ^ Cannabinoids and Feeding: The Role of the Endogenous Cannabinoid System as a Trigger for Newborn Suckling Archived 2020-10-01 at the Wayback Machine Women and Cannabis: Medicine, Science, and Sociology, 2002 The Haworth Press, Inc.
  68. ^
    PMID 26656029
    .
  69. PMID 29154942
    .
  70. ^ Williams, Florence (2012-06-16). "The wonder of breasts". The Guardian. London.
  71. PMID 19088308
    .
  72. PMID 25593150
    .
  73. ^
    PMID 28717367
    .
  74. PMID 22940915
    .
  75. PMID 26255679
    .
  76. PMID 30972555
    .
  77. ^ "Milk Oligosaccharides - an overview | ScienceDirect Topics". www.sciencedirect.com. Retrieved 2022-04-28.
  78. PMID 29924965
    .
  79. PMID 26375354
    .
  80. S2CID 26423226
    .
  81. OCLC 52113208
    .
  82. ^
    PMID 26292320
    .
  83. ^ "Breastfeeding | Health benefits for mother and baby". womenshealth.gov. 2010-08-01. Archived from the original on 2016-03-04. Retrieved 2011-10-26.
  84. PMID 27187450
    .
  85. PMID 27234413
    .
  86. ^ "What are the LLLI guidelines for storing my pumped milk?". Archived from the original on 2014-07-01. Retrieved 2014-07-16.
  87. ^ Protocol #8: Human milk storage information for home use for healthy full-term infants. Archived 2020-10-29 at the Wayback Machine Academy of Breastfeeding Medicine Protocol.
  88. ^ Department of Health, 1994. Weaning and the weaning diet. Report of the Working Group on the Weaning Diet of the Committee on Medical Aspects of Food Policy. London: HMSO. Report on Health and Social Subjects No 45.
  89. ^ a b "Vegetarian & Vegan Foundation". Archived from the original on 2014-08-21. Retrieved 2013-01-07.
  90. ^ "Vegetarian & Vegan Foundation". Archived from the original on 2014-08-11. Retrieved 2013-01-07.
  91. ^ FSA, 2002. McCance and Widdowson's The Composition of Foods, 6th summary edition. Cambridge, England, Royal Society of Chemistry.
  92. ^ MedlinePlus Medical Encyclopedia: Cow's milk for infants and children Archived 2016-07-05 at the Wayback Machine
  93. PMID 4036886
    .
  94. ^ "Breastfeeding: Human Milk Versus Animal Milk".{{cite web}}: CS1 maint: url-status (link)
  95. ^ "Milk, human, mature, fluid Nutrition Facts & Calories". Archived from the original on 29 November 2021. Retrieved 10 June 2018.{{cite web}}: CS1 maint: unfit URL (link)
  96. ^
    S2CID 33029715
    .
  97. ^
    PMID 26648652
    .
  98. ^
    PMID 11456429
    .
  99. ^ "Breastfeeding" (PDF). Office on Women's Health, U.S. Department of Health and Human Services. 2014. Archived from the original (PDF) on 14 May 2017. Retrieved 20 July 2017.Public Domain This article incorporates text from this source, which is in the public domain.
  100. ^ "Breastfeeding and Medication". AAP.org. Archived from the original on 2019-08-02. Retrieved 2019-08-02.
  101. ^
    PMID 23178070
    .
  102. ^
    S2CID 27763768
    .
  103. ^ "Thyroid Disease & Pregnancy". Office on Women's Health, U.S. Department of Health and Human Services. 1 February 2017. Retrieved 20 July 2017.Public Domain This article incorporates text from this source, which is in the public domain.
  104. ^ "Postpartum Thyroiditis" (PDF). American Thyroid Association. 2014. Retrieved 20 July 2017.
  105. PMID 22419310
    .
  106. ^ "Guidelines for the identification and management of substance use and substance use disorders in pregnancy" (PDF). World Health Organization. 2014. Retrieved 11 August 2017.
  107. ^
    PMID 24144714
    .
  108. ^ "Refrigerator Thermometers: Cold Facts about Food Safety". U.S. Food and Drug Administration. 14 September 2021.
  109. ^
    PMID 21387943
    .
  110. ^ a b OAKLANDER, MANDY (24 March 2015). "Don't Buy Your Breast Milk Online, Scientists Say". TIME. Retrieved 18 April 2024.
  111. ^ Erika, Edwards; Briggs, Bill (6 April 2015). "Breast Milk Bought Online Diluted With Cows Milk, Researchers Find". NBC News. Retrieved 18 April 2024.
  112. ^ OAKLANDER, MANDY (6 April 2015). "This Is What's Actually in the Breast Milk You Buy Online". TIME. Retrieved 18 April 2024.
  113. ^ Kraft, Amy (18 June 2015). "Adult health craze for human breast milk poses risks". CBS. Retrieved 13 January 2019.
  114. ^ "Swiss restaurant to serve meals cooked with human breast milk A Swiss gastronomist has stirred a controversy in the tranquil Alpine republic after announcing that he will serve meals cooked with human breast milk". The Daily Telegraph. London. 2008-09-17. Archived from the original on 2022-01-12. Retrieved 2010-04-26.
  115. ^ Black R (18 September 2008). "Restaurant Drops Plan to Cook with Breast Milk". New York Daily News. Archived from the original on 2011-08-05. Retrieved 2009-06-18.
  116. ^ "Breast milk ice cream goes on sale in Covent Garden". BBC News. London. 2011-02-24. Retrieved 2011-03-07.
  117. ^ "Baby Gaga breast milk ice cream seized for safety tests". BBC News. London. 2011-03-01. Retrieved 2011-03-07.
  118. ^ Frissell-Deppe T (2002). A Breastfeeding Mother's Secret Recipes: Breast milk Recipes, Fun Food for Kids and Quick Dishes!. Dracut, MA: JED Publishing.
  119. ISBN 978-0-19-264921-8
    .
  120. ^ Clínica busca cómo hacer queso de leche materna Archived 2020-10-03 at the Wayback Machine, Nación, 17 June 2007
  121. ^ Neporent L (17 February 2015). "Why Bodybuilders Are Pounding Down Breast Milk". ABC News. Retrieved 4 December 2015.
  122. ^ Easter M (2015-02-19). "Bodybuilders Are Drinking Human Breast Milk. Are They Insane, or Super Insane?". Men's Health. Retrieved 4 December 2015.
  123. PMID 34764390
    .
  124. ^
    PMID 12055065
    .
  125. ^ Silent Snow: The Slow Poisoning of the Arctic by Marla Cone, Grove Press.
  126. ^ CDC (2018). "Prescription Medication Use". Centers for Disease Control and Prevention. Retrieved 2019-08-02.
  127. PMID 34764390
    .

External links
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