NDV-HXP-S
SARS-CoV-2 | |
Vaccine type | viral vector or inactivated |
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Clinical data | |
Trade names | ButanVac (Brazil) COVIVAC (Vietnam) HXP-GPOVac (Thailand) Patria (Mexico) |
Other names | ADAPTCOV |
Routes of administration | Intramuscular,[1] Intranasal |
Part of a series on the |
COVID-19 pandemic |
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COVID-19 portal |
NDV-HXP-S (known as ButanVac[2][3] or ADAPTCOV[4] in Brazil, COVIVAC[5] in Vietnam, HXP-GPOVac[6] in Thailand, Patria[7] in Mexico) is a COVID-19 vaccine candidate developed under the leadership of Peter Palese, Adolfo García-Sastre, and Florian Krammer at the Icahn School of Medicine at Mount Sinai.[8][9]
The name NDV-HXP-S comes from the terms Newcastle disease virus, HexaPro, and spike protein.
Pharmacology
NDV-HXP-S uses the Newcastle disease virus as its viral vector. The platform can be live or inactivated.[9][11][12][13][14][15][16][excessive citations]
Manufacturing
Unlike vaccines such as Moderna's
History
Development
Its development was coordinated by the PATH Center for Vaccine Innovation and Access, and UT Austin and ISMMS have arranged royalty-free licensing agreements with labs and corporations in 80 countries. McLellan has noted that "the share of vaccines ['low- and middle-income countries' have] received so far is terrible".[8]
Clinical trials
As of December 2021, NDV-HXP-S is undergoing clinical trials in humans in at least four countries. In Brazil, on March 26, 2021, the
References
- ^ "Study of a Live rNDV Based Vaccine Against COVID-19". ClinicalTrials.gov. United States National Library of Medicine. 4 May 2021. NCT04871737. Retrieved 4 May 2021.
- ^ "Butantan vai desenvolver e produzir nova vacina contra a Covid-19; testes clínicos da ButanVac devem começar em abril". butantan.gov.br (in Portuguese). Retrieved 16 December 2021.
- Sao Paulo's Butantan biomedical institute said it will seek approval ... Butantan aims to produce 40 million doses of the Butanvac vaccine ... The vaccine was developed using a modified virus, which causes the Newcastle disease in birds ...
- ^ "Clinical Trial of the COVID-19 Vaccine (Recombinant, Inactivated) in Brazil (ADAPTCOV)". clinicaltrials.gov. United States National Library of Medicine. 6 August 2021. Retrieved 6 August 2021.
- ^ "A Phase 1/2 Safety and Immunogenicity Trial of COVID-19 Vaccine COVIVAC". clinicaltrials.gov. United States National Library of Medicine. April 2021. Retrieved 9 April 2021.
- ^ "Mahidol-GPO's human trials of its COVID-19 vaccine show promising results". Thai PBS World. 1 July 2021. Retrieved 19 July 2021.
- ^ Juarez C (22 April 2021). "Vacuna Patria: esto es lo que se sabe de su avance y eventual producción". The Logistics World. Retrieved 24 June 2021.
- ^ a b c d e Zimmer C (5 April 2021). "Researchers Are Hatching a Low-Cost Coronavirus Vaccine". The New York Times. Retrieved 7 April 2021.
- ^ PMID 33232870.
- ^ PMID 32703906.
- PMID 33232870.
- PMID 33348607.
- PMID 34544278.
- medRxiv 10.1101/2021.09.17.21263758.
- PMID 34603333.
- PMID 34868082.
- ^ Airhart M (5 April 2021). "Human Trials Begin for a Low-Cost COVID-19 Vaccine to Extend Global Access". University of Texas. Retrieved 7 April 2021.
- ^ Clinical trial number NCT04764422 for "Assess the Safety and Immunogenicity of NDV-HXP-S Vaccine in Thailand" at ClinicalTrials.gov
- ^ Wipatayotin A (11 February 2021). "Thai-made vaccine ready 'by next year'". Bangkok Post. Bangkok Post Public Company Limited. Retrieved 9 April 2021.
- ^ "Việt Nam's COVID vaccine developer stops third phase trial due to volunteers shortage". vietnamnews.vn. Retrieved 12 February 2023.