cAMP receptor protein

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CAMP receptor
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Not to be confused with C-reactive protein.
CAMP receptor protein
UniProt
P0ACJ8
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cAMP receptor protein (CRP; also known as

regulatory protein in bacteria
.

Protein

CRP

promoters of the genes it controls.[1][2] CRP then activates transcription through direct protein–protein interactions with RNA polymerase.[1][2]

The genes regulated by CRP are mostly involved in energy metabolism, such as

citrate, or the PEP group translocation system.[3][4] In Escherichia coli
, CRP can regulate the transcription of more than 100 genes.

The signal to activate CRP is the binding of cyclic AMP. Binding of cAMP to CRP leads to a long-distance signal transduction from the

C-terminal domain of the protein, which is responsible for interaction with specific sequences of DNA.[5]

At "Class I" CRP-dependent promoters, CRP binds to a DNA site located upstream of core promoter elements and activates transcription through protein–protein interactions between "activating region 1" of CRP and the C-terminal domain of

co-activator" proteins.[1][2]

At most CRP-dependent promoters, CRP activates transcription primarily or exclusively through a "recruitment" mechanism, in which protein–protein interactions between CRP and RNA polymerase assist binding of RNA polymerase to the promoter.[1]

References

  1. ^
    PMID 10550204
    .
  2. ^
    PMID 15102444
    .
  3. S2CID 6872903
    .
  4. S2CID 22913073
    .
  5. PMID 19359484
    .
  6. PMID 19903881
    .
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