CCL9
(Redirected from
CCL10
)Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | Chr 11: 83.46 – 83.47 Mb | n/a | |||||||
PubMed search | [1] | n/a |
View/Edit Human |
Chemokine (C-C motif) ligand 9 (CCL9) is a small
CCL9 is a chemokine involved in the process of signaling an antileukemic response and is a potential form of immunotherapy for
sickle cell anemia or extreme granulocytosis but if left untreated, it could transform into an acute form of leukemia. In order to treat CML, alpha and beta interferons (INFs) are used to regulate the process of binding the protein ICSBP to the gene BCR-ABL. CCL9 was proved to be a gene induced by ICSBP and IFN alpha and also a requirement in the expression of ICSBP in BCR-ABL transformed cells to generate an anti-leukemic immune protection via experimentation. CCL6 and CCL9 were overexpressed in BaF3 cells and injected with BCR-ABL into syngeneic mice. Although the mice still developed leukemia, it delayed the advancement of the disease by several weeks proving that CCL6 and CCL9 contribute to the creation of an anti-leukemic response within infected cells.[6][unreliable medical source
]
References