CCL8
Ensembl |
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| Location (UCSC) | Chr 17: 34.32 – 34.32 Mb | n/a | |||||||
| PubMed search | [2] | n/a | |||||||
| View/Edit Human | |||
Chemokine (C-C motif) ligand 8 (CCL8), also known as monocyte chemoattractant protein 2 (MCP2), is a protein that in humans is encoded by the CCL8 gene.[3][4]
CCL8 is a small
NK cells that are involved in the inflammatory response.[6][7] CCL8 elicits its effects by binding to several different cell surface receptors called chemokine receptors. These receptors include CCR1, CCR2B, CCR3 and CCR5.[7][8]
CCL8 is a CC chemokine that utilizes multiple cellular receptors to attract and activate human leukocytes. CCL8 is a potent inhibitor of
HIV1 by virtue of its high-affinity binding to the receptor CCR5, one of the major co-receptors for HIV1.[9] In addition, CCL8 attributes to the growth of metastasis in breast cancer cells. The manipulation of this chemokine activity influences the histology of tumors promoting steps of metastatic processes.[10] CCL8 is also involved in attracting macrophages to the decidua in labor.[11]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000108700 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: chemokine (C-C motif) ligand 8".
- ^ PMID 9119400.
- PMID 1613466.
- S2CID 30445255.
- ^ PMID 9468473.
- PMID 29281969.
- PMID 11087354.
- PMID 27181207.
- PMID 23451115.
External links
- Human CCL8 genome location and CCL8 gene details page in the UCSC Genome Browser.
Further reading
- Struyf S, Proost P, Vandercappellen J, et al. (2009). "Synergistic up-regulation of MCP-2/CCL8 activity is counteracted by chemokine cleavage, limiting its inflammatory and anti-tumoral effects". Eur. J. Immunol. 39 (3): 843–57. S2CID 41872921.
- Rom S, Rom I, Passiatore G, et al. (2010). "CCL8/MCP-2 is a target for mir-146a in HIV-1-infected human microglial cells". FASEB J. 24 (7): 2292–300. PMID 20181935.
- Menon R, Pearce B, Velez DR, et al. (2009). "Racial disparity in pathophysiologic pathways of preterm birth based on genetic variants". Reprod. Biol. Endocrinol. 7: 62. PMID 19527514.
- Segat L, Brandão LA, Guimarães RL, et al. (2010). "Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment". Vaccine. 28 (10): 2201–6. PMID 20056178.
- Rajaraman P, Brenner AV, Butler MA, et al. (2009). "Common variation in genes related to innate immunity and risk of adult glioma". Cancer Epidemiol. Biomarkers Prev. 18 (5): 1651–8. PMID 19423540.
- Han S, Lan Q, Park AK, et al. (2010). "Polymorphisms in innate immunity genes and risk of childhood leukemia". Hum. Immunol. 71 (7): 727–30. PMID 20438785.
- Velez DR, Fortunato SJ, Thorsen P, et al. (2008). "Preterm birth in Caucasians is associated with coagulation and inflammation pathway gene variants". PLOS ONE. 3 (9): e3283. PMID 18818748.
- Villa C, Venturelli E, Fenoglio C, et al. (2009). "CCL8/MCP-2 association analysis in patients with Alzheimer's disease and frontotemporal lobar degeneration". J. Neurol. 256 (8): 1379–81. S2CID 3147096.
- Siezen CL, Bont L, Hodemaekers HM, et al. (2009). "Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes". Pediatr. Infect. Dis. J. 28 (4): 333–5. S2CID 25601837.
- Vyshkina T, Sylvester A, Sadiq S, et al. (2008). "CCL genes in multiple sclerosis and systemic lupus erythematosus". J. Neuroimmunol. 200 (1–2): 145–52. PMID 18602166.
- Ruhwald M, Bodmer T, Maier C, et al. (2008). "Evaluating the potential of IP-10 and MCP-2 as biomarkers for the diagnosis of tuberculosis". Eur. Respir. J. 32 (6): 1607–15. PMID 18684849.
- Skibola CF, Bracci PM, Halperin E, et al. (2008). "Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma". PLOS ONE. 3 (7): e2816. PMID 18636124.
- Ockinger J, Stridh P, Beyeen AD, et al. (2010). "Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis". Genes Immun. 11 (2): 142–54. PMID 19865101.
- Xie Z, Zhang J, Wu J, et al. (2008). "Upregulation of mitochondrial uncoupling protein-2 by the AMP-activated protein kinase in endothelial cells attenuates oxidative stress in diabetes". Diabetes. 57 (12): 3222–30. PMID 18835932.
- Rajaraman P, Brenner AV, Neta G, et al. (2010). "Risk of meningioma and common variation in genes related to innate immunity". Cancer Epidemiol. Biomarkers Prev. 19 (5): 1356–61. PMID 20406964.
- Velez DR, Fortunato S, Thorsen P, et al. (2009). "Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants". Am. J. Obstet. Gynecol. 200 (2): 209.e1–27. PMID 19019335.
- Dean RA, Cox JH, Bellac CL, et al. (2008). "Macrophage-specific metalloelastase (MMP-12) truncates and inactivates ELR+ CXC chemokines and generates CCL2, -7, -8, and -13 antagonists: potential role of the macrophage in terminating polymorphonuclear leukocyte influx". Blood. 112 (8): 3455–64. PMID 18660381.
- Hori T, Naishiro Y, Sohma H, et al. (2008). "CCL8 is a potential molecular candidate for the diagnosis of graft-versus-host disease". Blood. 111 (8): 4403–12. PMID 18256320.
- Schuurhof A, Bont L, Siezen CL, et al. (2010). "Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls". Pediatr. Pulmonol. 45 (6): 608–13. S2CID 24678182.
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