CCR10

Source: Wikipedia, the free encyclopedia.
CCR10
Identifiers
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_016602

NM_007721

RefSeq (protein)

NP_057686

NP_031747

Location (UCSC)Chr 17: 42.68 – 42.68 MbChr 11: 101.06 – 101.07 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

C-C chemokine receptor type 10 is a protein that in humans is encoded by the CCR10 gene.[5][6]

Function

angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines.[6]

CCR10 is a

CCL27 and CCL28.[7] This receptor is normally expressed by melanocytes,[8] plasma cells and skin-homing T cells. B16 melanoma cell transduction of CCR10 significantly increases the development of lymph node metastasis in mice after inoculation in the skin,[9] suggesting a role for the receptor in directing metastasis. CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation.[10]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184451 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044052 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. PMID 7851889
    .
  6. ^ a b "Entrez Gene: CCR10 chemokine (C-C motif) receptor 10".
  7. S2CID 205467365
    .
  8. .
  9. .
  10. .

Further reading

External links


This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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