CD120

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CD120 (Cluster of Differentiation 120) can refer to two members of the

tumor necrosis factor receptor superfamily: tumor necrosis factor receptor 1 (TNFR1) and tumor necrosis factor receptor 2 (TNFR2).[1][2]

Receptor subtypes

There are two variants of the receptor, each encoded by a separate gene:

  • CD120a - TNFR1 - TNFR superfamily member 1A
  • CD120b - TNFR2 - TNFR superfamily member 1B

TNFR1 is the receptor type responsible for mediation of TNF-alpha induced sickness behavior,[3] and is involved in neurotoxic processes.[4] Elevated levels of TNFR1 has been found in severe mental disorders.[5]

Signaling pathway

TNF
-R1. Dashed grey lines represent multiple steps

See also

References

External links

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