CD120
Chr. 12 p13.2 | |||||||
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Chr. 1 p36.22 | |||||||
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CD120 (Cluster of Differentiation 120) can refer to two members of the
tumor necrosis factor receptor superfamily: tumor necrosis factor receptor 1 (TNFR1) and tumor necrosis factor receptor 2 (TNFR2).[1][2]
Receptor subtypes
There are two variants of the receptor, each encoded by a separate gene:
- CD120a - TNFR1 - TNFR superfamily member 1A
- CD120b - TNFR2 - TNFR superfamily member 1B
TNFR1 is the receptor type responsible for mediation of TNF-alpha induced sickness behavior,[3] and is involved in neurotoxic processes.[4] Elevated levels of TNFR1 has been found in severe mental disorders.[5]
Signaling pathway
See also
References
External links
- CD120a+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- CD120b+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)