Interleukin-6 receptor

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CD126
)
IL6R
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_000565
NM_001206866
NM_181359

NM_010559
NM_001310676

RefSeq (protein)

NP_001297605
NP_034689

Location (UCSC)Chr 1: 154.41 – 154.47 MbChr 3: 89.77 – 89.82 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Interleukin 6 receptor (IL6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor.

Function

Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.

In melanocytes IL6R gene expression may be regulated by MITF.[5]

Structure

The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. IL6R also denotes the human gene encoding this subunit. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[6] IL6R subunit is also shared by many other cytokines.

Interactions

Interleukin-6 receptor has been shown to

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160712 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027947 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. S2CID 24698373
    .
  6. ^ "Entrez Gene: IL6R interleukin 6 receptor".
  7. PMID 14557255
    .
  8. ^ .
  9. .
  10. .

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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