CD1D
(Redirected from
CD1d
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| Location (UCSC) | Chr 1: 158.18 – 158.19 Mb | Chr 3: 86.9 – 86.91 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
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CD1D is the
T cells
. CD1d is the only member of the group 2 CD1 molecules.
Biological significance
CD1d-presented lipid antigens activate a special class of T cells, known as
interferon-gamma and interleukin 4
production.
Nomenclature
CD1d is also known as R3G1
Ligands
Some of the known ligands for CD1d are:
- α-galactosylceramide (α-GalCer), a compound originally derived from the marine sponge Agelas mauritanius[6] with no physiological role but great research utility.
- α-invariant NKTs(iNKTs), a special kind of NKT.
- iGb3, a self antigen which has been implied in iNKT selection.[8]
- HS44, a synthetic amino cyclitolic ceramide analogue which has less contact with the TCR, activating iNKTs in a more constrained way than α-GalCer (specially in relation to Th2 cytokines production) and thus being more interesting for therapeutic use.[9]
CD1d tetramers
CD1d
tetramers are protein constructs composed of four CD1d molecules joined together and usually fluorescently labelled, used to identify NKT cells or other CD1d-reactive cells. In particular, type I NKT cells and some type II NKT cells are stained by them. A differentiation of these two types can be obtained in human by using an antibody against the TCR Vα24 chain, which is specific of type I NKT cells.[10]
Although they are the most widely used of CD1d oligomers, sometimes CD1d dimers (two units) or pentamers (five units) are used instead.[10]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000158473 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028076 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "P15813 (CD1D_HUMAN)". Uniprot. Retrieved 1 March 2013.
- PMID 22408579.
- PMID 17150027.
- PMID 16918447.
- PMID 22301545.
- ^ PMID 19055947.
Further reading
- Melián A, Beckman EM, Porcelli SA, Brenner MB (1996). "Antigen presentation by CD1 and MHC-encoded class I-like molecules". Curr. Opin. Immunol. 8 (1): 82–88. PMID 8729450.
- Joyce S (2001). "CD1d and natural T cells: how their properties jump-start the immune system". Cell. Mol. Life Sci. 58 (3): 442–469. S2CID 29982004.
- Sköld M, Behar SM (2003). "Role of CD1d-Restricted NKT Cells in Microbial Immunity". Infect. Immun. 71 (10): 5447–5455. PMID 14500461.
- Brigl M, Brenner MB (2004). "CD1: antigen presentation and T cell function". Annu. Rev. Immunol. 22 (1): 817–890. PMID 15032598.
- Stove V, Verhasselt B (2006). "Modelling thymic HIV-1 Nef effects". Curr. HIV Res. 4 (1): 57–64. PMID 16454711.
- Brutkiewicz RR (2006). "CD1d ligands: the good, the bad, and the ugly". J. Immunol. 177 (2): 769–775. PMID 16818729.
- Blumberg RS, Terhorst C, Bleicher P, et al. (1991). "Expression of a nonpolymorphic MHC class I-like molecule, CD1D, by human intestinal epithelial cells". J. Immunol. 147 (8): 2518–2524. S2CID 33639980.
- Balk SP, Bleicher PA, Terhorst C (1989). "Isolation and characterization of a cDNA and gene coding for a fourth CD1 molecule". Proc. Natl. Acad. Sci. U.S.A. 86 (1): 252–256. PMID 2463622.
- Calabi F, Jarvis JM, Martin L, Milstein C (1989). "Two classes of CD1 genes". Eur. J. Immunol. 19 (2): 285–292. S2CID 31384394.
- Yu CY, Milstein C (1990). "A physical map linking the five CD1 human thymocyte differentiation antigen genes". EMBO J. 8 (12): 3727–3732. PMID 2583117.
- Martin LH, Calabi F, Milstein C (1987). "Isolation of CD1 genes: a family of major histocompatibility complex-related differentiation antigens". Proc. Natl. Acad. Sci. U.S.A. 83 (23): 9154–9158. PMID 3097645.
- Balk SP, Burke S, Polischuk JE, et al. (1994). "Beta 2-microglobulin-independent MHC class Ib molecule expressed by human intestinal epithelium". Science. 265 (5169): 259–262. PMID 7517575.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. PMID 9373149.
- Kawano T, Cui J, Koezuka Y, et al. (1997). "CD1d-restricted and TCR-mediated activation of valpha14 NKT cells by glycosylceramides". Science. 278 (5343): 1626–1629. PMID 9374463.
- Katabami S, Matsuura A, Chen HZ, et al. (1998). "Structural organization of rat CD1 typifies evolutionarily conserved CD1D class genes". Immunogenetics. 48 (1): 22–31. S2CID 6715203.
- Somnay-Wadgaonkar K, Nusrat A, Kim HS, et al. (1999). "Immunolocalization of CD1d in human intestinal epithelial cells and identification of a beta2-microglobulin-associated form". Int. Immunol. 11 (3): 383–392. PMID 10221650.
- Campbell NA, Kim HS, Blumberg RS, PMID 10473580.
- Han M, Hannick LI, DiBrino M, Robinson MA (2000). "Polymorphism of human CD1 genes". Tissue Antigens. 54 (2): 122–127. PMID 10488738.
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External links
- CD1d+antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Human CD1A genome location and CD1A gene details page in the UCSC Genome Browser.
- Human CD1D genome location and CD1D gene details page in the UCSC Genome Browser.