Signal transducer CD24 also known as cluster of differentiation 24 or heat stable antigen CD24 (HSA) is a protein that in humans is encoded by the CD24gene.[3] CD24 is a cell adhesion molecule.
Function
CD24 is a
glycosyl phosphatidylinositol (GPI) link to the cell surface. The protein also contributes to a wide range of downstream signaling networks and is crucial for neural development.[5] Cross-linking of CD24 on the surface of neutrophils induces apoptosis,[6] and this appears to be defective in sepsis.[6] CD24 gene is found on chromosome 6 (6q21) An alignment of this gene's sequence finds genomic locations with similarity on chromosomes 1p36, 3p26, 15q21.3, 20q11.2 and Yq11.222. Whether transcription, and corresponding translation, occurs at each of these other genomic locations needs to be experimentally determined.[citation needed
Nagy B, Szendroi A, Romics I (June 2009). "Overexpression of CD24, c-myc and phospholipase 2A in prostate cancer tissue samples obtained by needle biopsy". Pathology & Oncology Research. 15 (2): 279–83.
Kim KH, Choi JS, Kim JM, Choi YL, Shin YK, Lee HC, Seong IO, Kim BK, Chae SW, Kim SH (March 2009). "Enhanced CD24 expression in endometrial carcinoma and its expression pattern in normal and hyperplastic endometrium". Histology and Histopathology. 24 (3): 309–16.
Bauerschmitz GJ, Ranki T, Kangasniemi L, Ribacka C, Eriksson M, Porten M, Herrmann I, Ristimäki A, Virkkunen P, Tarkkanen M, Hakkarainen T, Kanerva A, Rein D, Pesonen S, Hemminki A (July 2008). "Tissue-specific promoters active in CD44+CD24-/low breast cancer cells". Cancer Research. 68 (14): 5533–9.
Wang W, Wang X, Peng L, Deng Q, Liang Y, Qing H, Jiang B (January 2010). "CD24-dependent MAPK pathway activation is required for colorectal cancer cell proliferation". Cancer Science. 101 (1): 112–9.
Sano A, Kato H, Sakurai S, Sakai M, Tanaka N, Inose T, Saito K, Sohda M, Nakajima M, Nakajima T, Kuwano H (February 2009). "CD24 expression is a novel prognostic factor in esophageal squamous cell carcinoma". Annals of Surgical Oncology. 16 (2): 506–14.
Athanassiadou P, Grapsa D, Gonidi M, Athanassiadou AM, Tsipis A, Patsouris E (2009). "CD24 expression has a prognostic impact in breast carcinoma". Pathology, Research and Practice. 205 (8): 524–33.
Ronaghi M, Vallian S, Etemadifar M (December 2009). "CD24 gene polymorphism is associated with the disease progression and susceptibility to multiple sclerosis in the Iranian population". Psychiatry Research. 170 (2–3): 271–2.
