CD48
| CD48 | |||
|---|---|---|---|
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 1: 160.68 – 160.71 Mb | Chr 1: 171.51 – 171.53 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
CD48 antigen (Cluster of Differentiation 48) also known as B-lymphocyte activation marker (BLAST-1) or signaling lymphocytic activation molecule 2 (SLAMF2) is a protein that in humans is encoded by the CD48 gene.[5]
CD48 is a member of the
endothelial cells, and participates in activation and differentiation pathways in these cells.[5]
CD48 was the first B-cell-specific cellular differentiation antigen identified in transformed B lymphoblasts.[6][7]
Structure
The gene for CD48 is located in
glycosylated, with five possible asparagine-linked glycosylation sites at positions 40, 44, 104, 162 and 189, respectively.[6][7][8][12][13] Approximately 35-40% of the total molecular weight is attributed to the carbohydrate side chains.[12][13][14]
Interactions
CD48 was found to have a very low affinity for CD2 with dissociation constant () < 0.5 mM.natural killer cells (NK cells) and other leukocytes. The affinity of CD244 for CD48 is at = 8 μM which is about 5 - 10 times stronger than for CD2.[16][17][18]
Function
Cell distribution
CD48 is expressed on all
erythrocytes
(red blood cells).
T-cell activation
CD48 and CD2 molecular coupling together with other interaction pairs of CD28 and CD80, TCR and peptide-MHC and LFA-1 and ICAM-1 contribute to the formation of an immunological synapse between a T cell and an
Clinical significance
CD48 is being investigated amongst other markers in research on inflammation markers and therapies for HIV/AIDS.
Heterozygous germline mutation in a patient was associated with a recurrent inflammatory syndrome resembling hemophagocytic lymphohistiocytosis.[23]
![[icon]](/File:Wiki_letter_w_cropped.svg){kind=small} | This section is empty. You can help by adding to it. (August 2013) |
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000117091 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015355 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b c "Entrez Gene: CD48 CD48 molecule".
- ^ S2CID 45406805.
- ^ S2CID 13131389.
- ^ S2CID 32479661.
- PMID 1827826.
- ^ PMID 3181129.
- ^ PMID 2466936.
- ^ PMID 2828034.
- ^ PMID 10529350.
- ^ S2CID 40061476.
- S2CID 37921171.
- PMID 9841922.
- PMID 10556801.
- PMID 10658976.
- PMID 2088634.
- S2CID 5731764.
- S2CID 43466889.
- PMID 12180852.
- ^ Volkmer B, Planas R, Gossweiler E, Opitz L, Mauracher A, Nüesch U, Gayden T, Kaiser D, Drexel B, Dumrese C, Jabado N, Vavassori S, Pachlopnik Schmid J: Recurrent inflammatory disease caused by a heterozygous mutation in CD48. J Allergy Clin Immunol. 2019;144(5):1441-1445.e17. doi:10.1016/j.jaci.doi:10.1016/j.jaci.2019.07.038
Further reading
- Wong YW, Williams AF, Kingsmore SF, Seldin MF (1990). "Structure, expression, and genetic linkage of the mouse BCM1 (OX45 or Blast-1) antigen. Evidence for genetic duplication giving rise to the BCM1 region on mouse chromosome 1 and the CD2/LFA3 region on mouse chromosome 3". J. Exp. Med. 171 (6): 2115–30. PMID 1693656.
- Fisher RC, Thorley-Lawson DA (1991). "Characterization of the Epstein-Barr virus-inducible gene encoding the human leukocyte adhesion and activation antigen BLAST-1 (CD48)". Mol. Cell. Biol. 11 (3): 1614–23. PMID 1847502.
- Korínek V, Stefanová I, Angelisová P, Hilgert I, Horejsí V (1991). "The human leucocyte antigen CD48 (MEM-102) is closely related to the activation marker Blast-1". Immunogenetics. 33 (2): 108–12. S2CID 11414678.
- Garnett D, Barclay AN, Carmo AM, Beyers AD (1993). "The association of the protein tyrosine kinases p56lck and p60fyn with the glycosyl phosphatidylinositol-anchored proteins Thy-1 and CD48 in rat thymocytes is dependent on the state of cellular activation". Eur. J. Immunol. 23 (10): 2540–4. S2CID 9747812.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
- Solomon KR, Rudd CE, Finberg RW (1996). "The association between glycosylphosphatidylinositol-anchored proteins and heterotrimeric G protein alpha subunits in lymphocytes". Proc. Natl. Acad. Sci. U.S.A. 93 (12): 6053–8. PMID 8650218.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.
- Smith GM, Biggs J, Norris B, Anderson-Stewart P, Ward R (1998). "Detection of a soluble form of the leukocyte surface antigen CD48 in plasma and its elevation in patients with lymphoid leukemias and arthritis". J. Clin. Immunol. 17 (6): 502–9. S2CID 2538203.
- Latchman Y, McKay PF, Reiser H (1998). "Identification of the 2B4 molecule as a counter-receptor for CD48". J. Immunol. 161 (11): 5809–12. S2CID 7819238.
- Nakajima H, Cella M, Langen H, Friedlein A, Colonna M (1999). "Activating interactions in human NK cell recognition: the role of 2B4-CD48". Eur. J. Immunol. 29 (5): 1676–83. PMID 10359122.
- Shin JS, Abraham SN (2001). "Glycosylphosphatidylinositol-anchored receptor-mediated bacterial endocytosis". FEMS Microbiol. Lett. 197 (2): 131–8. PMID 11313125.
- Tangye SG, Cherwinski H, Lanier LL, Phillips JH (2001). "2B4-mediated activation of human natural killer cells". Mol. Immunol. 37 (9): 493–501. PMID 11163399.
- Suzuki T, Kiyokawa N, Taguchi T, Sekino T, Katagiri YU, Fujimoto J (2001). "CD24 induces apoptosis in human B cells via the glycolipid-enriched membrane domains/rafts-mediated signaling system". J. Immunol. 166 (9): 5567–77. PMID 11313396.
- Hawash IY, Hu XE, Adal A, Cassady JM, Geahlen RL, Harrison ML (2002). "The oxygen-substituted palmitic acid analogue, 13-oxypalmitic acid, inhibits Lck localization to lipid rafts and T cell signaling". Biochim. Biophys. Acta. 1589 (2): 140–50. PMID 12007789.
- Kim D, Hur DY, Kim YS, Lee K, Lee Y, Cho D, Kang JS, Kim YI, Hahm E, Yang Y, Yoon S, Kim S, Lee WB, Park HY, Kim YB, Hwang YI, Chang KY, Lee WJ (2002). "CM1 ligation initiates apoptosis in a caspase 8-dependent manner in Ramos cells and in a mitochondria-controlled manner in Raji cells". Hum. Immunol. 63 (7): 576–87. PMID 12072193.
- Zhu B, Davies EA, van der Merwe PA, Calvert T, Leckband DE (2002). "Direct measurements of heterotypic adhesion between the cell surface proteins CD2 and CD48". Biochemistry. 41 (40): 12163–70. PMID 12356317.
- Wei J (2005). "Expression and characterisation of recombinant human CD48 and isolation of a human anti-CD48 monoclonal antibody by phage display". Journal of Chemical Technology and Biotechnology. 80 (7): 782–795. .
- Wei J (2008). "Cytotoxic Activity of CD48 Monoclonal Antibodies Against Human Lymphoma Cells". The Open Biotechnology Journal. 2: 219–223. .
External links
- CD48+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Human CD48 genome location and CD48 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.