Integrin alpha-1
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CD49a
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| Location (UCSC) | Chr 5: 52.79 – 52.96 Mb | Chr 13: 115.09 – 115.24 Mb | |||||||
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Integrin alpha-1 also CD49a is an integrin alpha subunit encoded in humans by the gene ITGA1. It makes up half of the α1β1 integrin duplex. Though CD49a can bind a number of ligands including collagen IV, collagen I, and others.[5]
CD49a has been implicated as a marker of tissue resident memory T cells, where it may be coexpressed with other markers CD103 and CD69.[6] It has been shown to affect the motility of T cells.[7]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000213949 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000042284 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 25023165.
- PMID 34566986.
- PMID 32439709.
Further reading
- Virtanen I, Korhonen M, Kariniemi AL, et al. (1991). "Integrins in human cells and tumors". Cell Differ. Dev. 32 (3): 215–27. PMID 2099238.
- Plenz GA, Deng MC, Robenek H, Völker W (2003). "Vascular collagens: spotlight on the role of type VIII collagen in atherogenesis". Atherosclerosis. 166 (1): 1–11. PMID 12482545.
- Clover J, Dodds RA, Gowen M (1992). "Integrin subunit expression by human osteoblasts and osteoclasts in situ and in culture". J. Cell Sci. 103 (1): 267–71. PMID 1429908.
- Bodary SC, McLean JW (1990). "The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line". J. Biol. Chem. 265 (11): 5938–41. PMID 1690718.
- Sonnenberg A, Linders CJ, Modderman PW, et al. (1990). "Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8". J. Cell Biol. 110 (6): 2145–55. PMID 1693624.
- Belkin VM, Belkin AM, Dol'nikova AE, et al. (1992). "[Isolation and characteristics of ligand specificity of VLA-1 integrin from human smooth muscles]". Biokhimiia. 56 (12): 2198–206. PMID 1807406.
- Bank I, Roth D, Book M, et al. (1991). "Expression and functions of very late antigen 1 in inflammatory joint diseases". J. Clin. Immunol. 11 (1): 29–38. S2CID 6198792.
- Tabibzadeh S (1990). "Evidence of T-cell activation and potential cytokine action in human endometrium". J. Clin. Endocrinol. Metab. 71 (3): 645–9. PMID 2144294.
- Tawil NJ, Houde M, Blacher R, et al. (1990). "Alpha 1 beta 1 integrin heterodimer functions as a dual laminin/collagen receptor in neural cells". Biochemistry. 29 (27): 6540–4. PMID 2169872.
- Belkin VM, Belkin AM, Koteliansky VE (1990). "Human smooth muscle VLA-1 integrin: purification, substrate specificity, localization in aorta, and expression during development". J. Cell Biol. 111 (5 Pt 1): 2159–70. PMID 2229189.
- MacDonald TT, Horton MA, Choy MY, Richman PI (1990). "Increased expression of laminin/collagen receptor (VLA-1) on epithelium of inflamed human intestine". J. Clin. Pathol. 43 (4): 313–5. PMID 2341567.
- Takada Y, Strominger JL, Hemler ME (1987). "The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis". Proc. Natl. Acad. Sci. U.S.A. 84 (10): 3239–43. PMID 3033641.
- Hemler ME, Huang C, Schwarz L (1987). "The VLA protein family. Characterization of five distinct cell surface heterodimers each with a common 130,000 molecular weight beta subunit". J. Biol. Chem. 262 (7): 3300–9. PMID 3546305.
- Kono Y, Yang S, Letarte M, Roberts EA (1996). "Establishment of a human hepatocyte line derived from primary culture in a collagen gel sandwich culture system". Exp. Cell Res. 221 (2): 478–85. PMID 7493648.
- Eglinton BA, Roberton DM, Cummins AG (1995). "Phenotype of T cells, their soluble receptor levels, and cytokine profile of human breast milk". Immunol. Cell Biol. 72 (4): 306–13. S2CID 25016970.
- Salter DM, Godolphin JL, Gourlay MS (1995). "Chondrocyte heterogeneity: immunohistologically defined variation of integrin expression at different sites in human fetal knees". J. Histochem. Cytochem. 43 (4): 447–57. PMID 7897185.
- Pfaff M, Aumailley M, Specks U, et al. (1993). "Integrin and Arg-Gly-Asp dependence of cell adhesion to the native and unfolded triple helix of collagen type VI". Exp. Cell Res. 206 (1): 167–76. PMID 8387021.
- Briesewitz R, Epstein MR, Marcantonio EE (1993). "Expression of native and truncated forms of the human integrin alpha 1 subunit". J. Biol. Chem. 268 (4): 2989–96. PMID 8428973.
- Langholz O, Röckel D, Mauch C, et al. (1996). "Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins". J. Cell Biol. 131 (6 Pt 2): 1903–15. PMID 8557756.
External links
- CD49a+antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ITGA1 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine
- Human ITGA1 genome location and ITGA1 gene details page in the UCSC Genome Browser.
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Integrin alpha-1
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