CD6
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CD6 (Cluster of Differentiation 6) is a human protein encoded by the CD6 gene.[5][6]
Function
This gene encodes a protein found on the outer membrane of
T cell activation.[5]
Clinical significance
Certain alleles of this gene may be associated with susceptibility to multiple sclerosis.[7][8]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000013725 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024670 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: CD6 CD6 molecule".
- PMID 7760007.
- PMID 19525953.
- PMID 21849685.
Further reading
- Aruffo A, Melnick MB, Linsley PS, Seed B (1991). "The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins". J. Exp. Med. 174 (4): 949–52. PMID 1919444.
- Swack JA, Mier JW, Romain PL, Hull SR, Rudd CE (1991). "Biosynthesis and post-translational modification of CD6, a T cell signal-transducing molecule". J. Biol. Chem. 266 (11): 7137–43. PMID 2016320.
- Tsuge I, Utsumi KR, Ueda R, Takamoto S, Takahashi T (1985). "Assignment of gene coding human T-cell differentiation antigen, Tp120, to chromosome 11". Somat. Cell Mol. Genet. 11 (3): 217–22. S2CID 39343360.
- Whitney GS, Starling GC, Bowen MA, Modrell B, Siadak AW, Aruffo A (1995). "The membrane-proximal scavenger receptor cysteine-rich domain of CD6 contains the activated leukocyte cell adhesion molecule binding site". J. Biol. Chem. 270 (31): 18187–90. PMID 7543097.
- Robinson WH, Neuman de Vegvar HE, Prohaska SS, Rhee JW, Parnes JR (1995). "Human CD6 possesses a large, alternatively spliced cytoplasmic domain". Eur. J. Immunol. 25 (10): 2765–9. S2CID 8996113.
- Wee S, Schieven GL, Kirihara JM, Tsu TT, Ledbetter JA, Aruffo A (1993). "Tyrosine phosphorylation of CD6 by stimulation of CD3: augmentation by the CD4 and CD2 coreceptors". J. Exp. Med. 177 (1): 219–23. PMID 7678115.
- Bowen MA, Whitney GS, Neubauer M, Starling GC, Palmer D, Zhang J, Nowak NJ, Shows TB, Aruffo A (1997). "Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms". J. Immunol. 158 (3): 1149–56. S2CID 24196035.
- Kobarg J, Whitney GS, Palmer D, Aruffo A, Bowen MA (1998). "Analysis of the tyrosine phosphorylation and calcium fluxing of human CD6 isoforms with different cytoplasmatic domains". Eur. J. Immunol. 27 (11): 2971–80. S2CID 20897222.
- Singer NG, Mitra R, Lialios F, Richardson BC, Marks RM, Pesando JM, Fox DA, Nickoloff BJ (1998). "CD6 dependent interactions of T cells and keratinocytes: functional evidence for a second CD6 ligand on gamma-interferon activated keratinocytes". Immunol. Lett. 58 (1): 9–14. PMID 9436462.
- Gimferrer I, Farnós M, Calvo M, Mittelbrunn M, Enrich C, Sánchez-Madrid F, Vives J, Lozano F (2003). "The accessory molecules CD5 and CD6 associate on the membrane of lymphoid T cells". J. Biol. Chem. 278 (10): 8564–71. PMID 12473675.
- Shin BK, Wang H, Yim AM, Le Naour F, Brichory F, Jang JH, Zhao R, Puravs E, Tra J, Michael CW, Misek DE, Hanash SM (2003). "Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function". J. Biol. Chem. 278 (9): 7607–16. PMID 12493773.
- Gimferrer I, Ibáñez A, Farnós M, Sarrias MR, Fenutría R, Roselló S, Zimmermann P, David G, Vives J, Serra-Pagès C, Lozano F (2005). "The lymphocyte receptor CD6 interacts with syntenin-1, a scaffolding protein containing PDZ domains". J. Immunol. 175 (3): 1406–14. PMID 16034076.
- Kato Y, Tanaka Y, Hayashi M, Okawa K, Minato N (2006). "Involvement of CD166 in the activation of human gamma delta T cells by tumor cells sensitized with nonpeptide antigens". J. Immunol. 177 (2): 877–84. PMID 16818742.
- Ibáñez A, Sarrias MR, Farnós M, Gimferrer I, Serra-Pagès C, Vives J, Lozano F (2006). "Mitogen-activated protein kinase pathway activation by the CD6 lymphocyte surface receptor". J. Immunol. 177 (2): 1152–9. PMID 16818773.
- Hassan NJ, Simmonds SJ, Clarkson NG, Hanrahan S, Puklavec MJ, Bomb M, Barclay AN, Brown MH (2006). "CD6 Regulates T-Cell Responses through Activation-Dependent Recruitment of the Positive Regulator SLP-76". Mol. Cell. Biol. 26 (17): 6727–38. PMID 16914752.
- Castro MA, Oliveira MI, Nunes RJ, Fabre S, Barbosa R, Peixoto A, Brown MH, Parnes JR, Bismuth G, Moreira A, Rocha B, Carmo AM (2007). "Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse". J. Immunol. 178 (7): 4351–61. PMID 17371992.
- Sarrias MR, Farnós M, Mota R, Sánchez-Barbero F, Ibáñez A, Gimferrer I, Vera J, Fenutría R, Casals C, Yélamos J, Lozano F (2007). "CD6 binds to pathogen-associated molecular patterns and protects from LPS-induced septic shock". Proc. Natl. Acad. Sci. U.S.A. 104 (28): 11724–9. PMID 17601777.
External links
- CD6+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Human CD6 genome location and CD6 gene details page in the UCSC Genome Browser.
- Overview of all the structural information available in the PDB for UniProt: P30203 (Human T-cell differentiation antigen CD6) at the PDBe-KB.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.