CD78
CD78 is a
B-cells. It is considered a pan-B cell antigen.[1] Other names include Cdw78, Ba antigen, Leu21 and LO-panB-a.[2]
Function
It is part of the MHC class II.[1]
Expression
CD78 is expressed on all stages of B cell development from pre-B cell through
plasma cells.[3]
Its expression is strongest on activated B cells.
It is also present on tissue
epithelial cells.[2]
Clinical significance
With flow cytometry, it can be used to detect B cells during many stages of their development.[2] It is one of relatively few markers usefully expressed on plasma cells, and when combined with detection of markers such as CD22, can be used to determine the relative proportion of plasma cells.[3]
References
- ^ PMID 8527406.
- ^ a b c "CD78 antibody (60-3G2) (ab24151) datasheet". Abcam. Retrieved 2008-10-28.
- ^ ISBN 978-3-7186-0596-5.